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      저자 : 임길홍(Kil Hong Lim) (검색결과 3 건)
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        천골무발육증

        성철수(Chul Soo Sung),임길홍(Kil Hong Lim),최일용(Il Yong Choi),김광희(Kwang Hoe Kim) 대한정형외과학회 1980 대한정형외과학회지 Vol.15 No.2

      • 정형외과 영역의 동통에 대한 Flurbiprofen의 임상연구

        임길홍,김광회 최신의학사 1979 最新醫學 Vol.22 No.7

      • Rhombic sulfur(斜方黃) 및 trimethoprim-sulfamethoxazole이 간에 미치는 영향에 관한 실험적 연구

        임길홍,김광회,구국회 한양대학교 의과대학 1984 한양의대 학술지 Vol.4 No.2

        Rhombic sulfur has been not only believed traditionally as marvelous tonic, but also used for extermination of insects, sterilization and disinfection. Among many chemotherapeutants, particularly sulfa drugs have been believed to be dramatically effective for various inflammatory diseases and disposed to use so improperly that it has become an important problem in modern medicine. von Oettingen reported on the toxic symptom caused by an excessive intake of sulfur. In that while, toxic changes of various sulfa drugs on the liver have been studied by many investigators. However, the mechanism and pattern of sulfur and sulfa drug induced injuries have not been settled yet. This study is conducted anatopathologically and biochemically to evaluate the effects of rhombic sulfur and trimethoprim-sulfamethoxazole (Bactrim) upon the liver and blood. One hundred fifty Sprague-Dawley rats weighing about 200g have been used for the experiment and divided into 1) basic diet fed group (control), 2) rhombic sulfur administered group and 3) Bactrim administered group. The basic diet was nutritionally composed of adequate solid diet, and each rat was administered orally 15-20g of basic diet per day, Rhombic sulfur (25, 250mg), Bactrim (20, 200mg) were administered to appropriate group orally per rat per day. In doing this, the liver has been examined grossly and microscopically, and the serum glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase, total bilirubin, hemoglobin levels and white cell series in each rat have been also measured. The results obtined from this study are as follows: 1) In both rhombic sulfur administered group and Bactrim administered group, serum GOT, GPT, alkaline phosphatase, total bilirubin, eosinophil and monocyte were increased, while hemoglobin and neutrophil decreased. The hepatic cord cells revealed various degree of swelling, fatty change and necrosis. These changes in the rhombic sulfur administered geoup were more severe than that of the Bactrim administered group. 2) Particularly morphologic changes were directly proportional to the quantity and duration of rhombic sulfur and Bactrim administration.

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