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마지 바이러스 : I . 한국산 등줄쥐에서 분리한 새로운 한타바이러스의 동정 및 항원적 특성
이평우,정동훈,김윤철 대한바이러스학회 1992 Journal of Bacteriology and Virology Vol.22 No.2
Maaji virus, a new hantavirus, was isolated from Korean Apodemus captured in Maaji-ri, Jeoksung-myun, Paju-goon and characterized in antigenic and virologic properties. The obtained results are as follows : 1. By differential immunoblot (DIB) test utilizing strips which prepared from Prospect Hill virus, 3.6 % (6/168) of positive sera from Korean patients of hemorrhagic fever with renal syndrome (HFRS) and 81.8 (9/11) and 12.5 % (1/8) of positive sera from Korean Apodemus mice captured in Paju and in Yunchun areas were identified as so-called the seropattern V which is differ from seropattern I (Hantaan seropattern) by the DIB pattern and also which has been recognized among positive sera from HFRS patients in some areas of eastern Europe (Yugoslaia and Albania) previously. This is the first evidence on the seropattern V among Korean HFRS patients and Apodemus mice. 2. The assay of Maaji viral antigen has been carried out by differential immunofluorescence (DIF) and plaque reduction neutralization (PRN) tests and the antigenicity was compared with other serotypes of hantavirus. Anti-Maaji virus antibody prepared in rats showed rather higher antibody titers against Prospect Hill and Puumala viruses as compared with that of anti-Hantaan virus antibody. However the antibody reacted in equal level with anti-Hantaan virus antibody against Hantaan virus. This pattern on immunofluorescent antibody titer represents the typical feature of seropattern V demonstrated previously. Korean and Yugoslavian HFRS patients sere selected by DIB test also showed identical feature with anti Maaji virus antiserum as determined by additional DIF an PRN tests. Anti-Maaji virus antiserum and the sera selected from patients of Korea and Yugoslavia were able to neutralize Maaji virus in highest level and relatively higher cross neutralization was observed between those sera and Hantaan virus. 3. The plaque feature of Maaji virus was also different in size from other serotypes of hantavirus. The most biggist plaque was formed by Maaji virus then comes Hantaan, Seoul and Prospect Hill virus in that order. Above results suggest that Maaji virus is similar with Hataan virus but distinct from other known serotypes of hantavirus in the antigenicity and some limited virologic property. Especially, the results implicate that Maaji virus is identical (if not, very close) to the virus which cause V type HFRS in eastern European countries.
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