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        급성 췌장염의 진단에 있어서 Urinary Trypsinogen-2 Dipstick 검사의 유용성

        황성준 ( Seoung Joon Hwang ),정준표 ( Jun Pyo Chung ),김영균 ( Young Gyun Kim ),송대훈 ( Dae Hoon Song ),이재성 ( Jae Sung Lee ),백승석 ( Seung Seok Baek ),김도연 ( Do Yun Kim ),이덕용 ( Dok Yong Lee ),정연수 ( Yon Soo Jeong ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.6

        Background/Aims: The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis. Methods: Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls. Results: On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992. Conclusions: Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity. (Korean J Gastro-enterol 2004;43:364-369)

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        한국인의 기능성 위장관장애의 진단에 있어서 로마기준2의 유용성

        지상원 ( Sang Won Ji ),박효진 ( Hyo Jin Park ),최재필 ( Jae Phil Choi ),이태희 ( Tae Hee Lee ),이덕용 ( Dok Yong Lee ),이상인 ( Sang In Lee ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3

        Background/Aims: The aim of this study was to determine whether symptoms of patients with functional gastrointestinal disorders (FGIDs) can be classified according to the Rome II criteria. Methods: Consecutive patients newly visiting Yongdong Severance Hosipital for evaluation of their gastrointestinal symptoms were recruited. Factor analysis was used to identify symptom clusters of the patients with FGIDs. Results: Among 274 patients, 207 patients (75.5%) had FGIDs. Thirty-nine of the 207 patients (18.8%) without organic diseases did not fulfill symptom duration defined by Rome II criteria, and other 168 patients (81.2%) satisfied the Rome II criteria. Factor analysis of symptoms of 168 patients indicated the symptoms of FGIDs such as globus, functional heartburn, dysmotility-like dyspepsia, irritable bowel syndrome, functional constipation, functional diarrhea, functional abdominal pain, functional fecal incontinence, and levator ani syndrome. Functional dysphagia and aerophagia could be regarded as one factor and functional vomiting and acid reflux could be merged as another factor. The proportions of patients suffering from functional esophageal, gastroduodenal, abdominal pain, bowel and anorectal disorders were 18.5%, 41.7%, 2.4%, 60.7% and 3.0%, respectively. Forty-one patients (24.4%) suffered from more than two symptoms of FGIDs, which belonged to the different anatomic region. Conclusions: The Rome II criteria could be applied to Korean patients with FGIDs. (Korean J Gastroenterol 2003;41:183-189)

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