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뇌 정위장치를 이용한 뇌 스파르가눔의 제거 : 1예 보고 A Case Report
윤이규,최순관,김범태,신원한,변박장 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.9
Intracerebral sparganosis, caused by the Plerocercoid of Spirometra mansoni, is very rare. A 54-yearsld man, who has a history of having eaten raw frogs and snakes 20 years ago, was admitted with 2 years duration of focal seizure and monoparesis on right upper extremity. The brain CT scan and MRI demonstrated extensive and irregular hypodense lesion with punctate calcification in subcortical region of left parietal lobe. A whitish ribbon-like moving parasite could be picked up using CRW stereotactic frame under local anesthesia. On pathological examination was disclosed a sparganum with characteristic calcospherule. Also, preoperative ELISA test for sparganum-specific antibody(1gG) showed positive reaction to sparganum absorbance 1.04 in Serum and 0.61 in CSF, respectively(normal abs. : below 0.22). Immediately akrremoval of parasite, the seizure and motor weakness disappeared. Stereotactic removal of cerebral sparganum can be considered a useful method in selected patients.
좌측 측두골의 골융해성 종괴로 발현한 악성 섬유성조직구종 : 증례보고 A Case Report
윤이규,신원한,김범태,최순관,변박장,이동화 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.4
Malignant fibrous histiocytoma(MFH) is well known as a soft tissue tumor of the extremities and retroperitoneum, but MFH of the skull is very rare. We report a case of MFH arising from the temporal bone in a 27-year-old male. This tumor presented as an osteolytic lesion and soft tissue mass on the left temporal bone without obvious invasion of the underlying brain parenchyme. The patient underwent tumor and bone removal, followed by radiation therapy. Histologic examination disclosed pleomorphic spindle cells in a storiform pattern and tumor cells showed positive reaction for vimentin, lysozyme, α1-antitrypsin and α1-antichymotrypsin in immunohistochemical stain.
아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가
김정균,윤이규,고영심,윤웅찬,박무영,문경호 대한약학회 1983 약학회지 Vol.27 No.4
Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low $ED_{50}$ value of $9.6{\mu}g/ml$.
뇌혈관조영술시 재파열된 동맥류 2례 : 증례보고 Report of Two Cases
도재원,윤이규,배학근,목진호,이경석,윤일규,변박장 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.11
We report two cases of reruptured anterior communicating artery aneurysm during cerebral angiography in one aged 80years and the other aged 59years. Both patients had emergency angiography on Day 0, within 5 hours of the latest rupture. The prognosis was very poor. We stressed the importance of the time interval between the latest rupture and angiography.