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- 저자 : 윤영필(Yun Young Pil) (검색결과 3 건)
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파골세포 분화능을 세포사로 억제하는 알렌드로네이트의 효과
윤영필 ( Young Pil Yun ),김성은 ( Sung Eun Kim ),문호진 ( Ho Jin Moon ),권일근 ( Il Keun Kwon ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Osteoclasts regulate bone homeostasis and have a key role in bone degenerative processes. Mouse RAW264.7 macrophage cells have been shown to retain the capacity to differentiate into osteoclast-like cells in the presence of a receptor activator of nuclear factor kappa B ligand(RANKL), which is essential and sufficient to promote the maturation of osteoclasts. When treated with RANKL, RAW264.7 cells express high levels of osteoclastassociated genes such as tartrate-resistant acid phosphatase(TRAP), which has been widely used to assess bone resorption. In this study, we hypothesized that alendronate prevents RANKL-induced osteoclast-like cells, which are known to play important roles in the bone-resorptive responses. We investigated that occurred TRAP-positive area and the expression patterns of two important proteolytic enzymes, cathepsin K and Matrix Metalloproteinase- 9(MMP-9) during RANKL-induced osteoclast differentiation in RAW264.7 cells. These results showed that increased TRAP-positive staining and both cathepsin K and MMP-9 mRNA expression levels on RANKL-induced osteoclast differentiation during 4 days. Especially, alendronate increased caspase-3 expression for apoptosis with Western blot analysis. These results showed that alendronate cause apoptosis and thus osteoclast differentiation inhibit. This finding may help the understanding of the osteolytic and osteoporotic processes responsible for bone diseases, including osteoporosis and periodontal diseases.
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P-Version Model of Stress Concentration Around a Circular Hole in Finite Strips
우광성,이채규,윤영필,Woo, Kwang Sung,Lee, Chae Gyu,Yun, Young Pil Korean Society of Civil Engeneers 1992 대한토목학회논문집 Vol.12 No.4
면내거동과 휨거동을 받는 원형구멍을 갖는 유한평판에서 원형구멍 주위의 응력을 모델링하기 위해 p-version 유한요소법이 제시되었으며, 또한 동일한 문제로써 원형구멍으로부터 발생된 균열해석을 위해 균열확장법이 사용되었다. 적분형 르장드르함수에 기초한 p-version 유한요소법이 원형구멍 주위의 응력경사가 심한 기하형상을 모델링하는데 적합함을 보여준다. 한편, 원형 경계조건을 표현하는데 이산화오차를 피하기 위해 초유한사상기법이 사용되었다. 앞에서 제시된 방법을 통한 수치해석 결과는 Nisida, Howland, Newman 등의 실험 및 이론결과와 종래의 유한요소법에 의한 수치해석결과와 비교하여 우수한 값을 보여 주고 있다. This paper presents a p-version finite element approach for modeling the stress distribution around a circular hole in a finite strip subjected to membrane and flexural behaviors. Also, same problem with a crack emanating from a perforated tension strip was solved by virtual crack extension method. The p-version of the finite element method based on integrals of Legendre polynomials is shown to perform very well for modeling geometries with very steep stress gradients in the vicinity of a circular cutout. Here, the transfinite mapping technique for circular boundaries was used to avoid the discretization errors. The numerical results from the proposed scheme have a good comparison with those by Nisida, Howland, Newman etc. and the conventional finite element approach.
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