http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ascorbic Acid가 Ferrous Sulfate의 Rat 소장흡수에 미친 영향
이진환,최준식,범진필,유철진 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1
This paper was attempted to investigate the effect of ascorbic acid on the dissolution rates, the partition coefficient and the absorption rates of ferrous sulfate from rat small intestine. Ascorbic acid increased the dissolution of ferrous sulfate using basket method. Ascorbic acid increased the partition coefficient of ferrous sulfate in n-octanol and phosphate buffer (pH4.0)system. The dissolution rate and the partition coefficient of ferrous sulfate were increased by increasing dose of ascorbie acid. Ascorbic acid significantly enhanced the absorption rate of ferrous sulfate from rat small intestine. The absorption rate was enhanced by increasing dose of ascorbic acid. The correlation of the dissolution rate and the absorption rate, and the correlation of partition and the absorption rate were found the linear relationship respectively in presence of ascorbic acid. From the results of this experiment, it can be concluded that ferrous sulfate combined with ascorbic acid is more available than ferrous sulfate single for both anemia therapeutics and redusing side effect.