http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신성 고혈압 쥐에서 Pinacidil에 의한 혈관 이완반응에 있어 산소유리기의 역할
염철호 ( Cheol Ho Yeum ),최석 ( Seok Choi ),유임준 ( Im Joon Yoo ),위희욱 ( Hee Wook Whi ),전제열 ( Jae Yeoul Jun ),김현일 ( Hyun Il Kim ),신혜랑 ( Hye Rang Shin ),오현정 ( Hyun Jung Oh ),정종훈 ( Jong Hoon Chung ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6
Purpose: Evidence has emerged that oxygen-derived free radicals may induce vascular relaxations via ATP-sensitive K+ (KATP) channels and the level of free radicals is increased in animal models of hypertension. The present study was conducted to determine whether relaxations to an KATP channel opener, pinacidil, are increased in the aorta from two-kidney, one clip (2K1C) hypertensive rats and whether free radial scavengers reduce these relaxations. Methods: 2K1C hypertension was induced by clipping the left renal artery and age-matched control rats received a sham treatment. Rings of aortae without endothelium were suspended for isometric force recording. Results: Relaxations to pinacidil (10-8 to 10-5 M), which are abolished by glibenclamide (10-5 M), were augmented in the aorta from 2K1C rats, compared to those from control rats. In the aorta from 2K1C rats, catalase (1,200 U/mL), but neither superoxide dismutase (150 U/mL) nor deferoxamine (10-4 M), reduced relaxations to pinacidil, whereas in the aorta from control rats, the free radical scavengers did not affect these relaxations. Conclusion: These results suggest that in 2K1C hypertension, vasorelaxation to an KATP channel opener is augmented and that hydrogen peroxide in smooth muscle cells may partly contribute to these relaxations.
신혈관성 고혈압쥐에서 Atrial Natriuretic Peptide가 혈관 기초장력에 미치는 영향
최석 ( Seok Choi ),김명룡 ( Myung Young Kim ),조남수 ( Nam Soo Cho ),선재명 ( Jae Myung Sun ),위희욱 ( Hee Wook Whi ),전제열 ( Jae Yeoul Jun ),윤평진 ( Pyung Jin Yoon ),정종훈 ( Jong Hoon Chung ),염철호 ( Cheol Ho Yeum ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.5
Purpose: Hypertension may be involved an alteration of intrinsic basal tone in vascular smooth muscle. The purpose of this study was to investigate the vasorelaxant effect of atrial natriuretic peptide (ANP) on isolated non-contracted aorta from two-kidney, one clip (2K1C) renovascular hypertensive rats. Methods: 2K1C hypertension was induced by clipping the left renal artery and were used 6 weeks later. Age-matched rats receiving a sham treatment, which served as controls. The thoracic aortae were mounted in tissue baths to measure the isometric tension. Results: ANP diminished basal tone in previously unstimulated thoracic aortic rings from 2K1C hypertensive rats, while it had no effect in the control rats. Endothelial destruction potentiated the vasorelaxant effect of ANP on basal tone in 2K1C rats. A similar potentiation of the ANP response was observed by pre-treatment with Nω-nitro-L-arginine methyl ester (L-NAME) or methylene blue in aortic rings with endothelium. Treatment with calcium-free Krebs decreased basal tone and abolished ANP-response. These effects were observed only in aortic rings from 2K1C rats. Similarly, staurosporine and calphostin C, inhibitors of protein kinase C (PKC), lowered basal tone and abolished ANP-response in hypertensive rats. Conclusion: These results demonstrate that ANP has a vasorelaxant effect on basal tone in 2K1C renovascular hypertension. Inhibition of ANP effects on basal tone by calcium-free Krebs and PKC antagonists suggests that altered Ca2+-active tone is involved in hypertension, that modifies the response of vascular smooth muscle to the ANP.