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Ti-6Al-4V 비드코팅 임프란트 시제품의 골유착에 대한 실험적 연구
우진오,박봉욱,변준호,김승언,김규천,박봉수,김종렬,Woo, Jin-Oh,Park, Bong-Wook,Byun, June-Ho,Kim, Seung-Eon,Kim, Gyoo-Cheon,Park, Bong-Soo,Kim, Jong-Ryoul 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.1
The geometric design of an implant surface may play an important role in affecting early osseointegration. It is well known that the porous surfaced implant had much benefits for the osseointegration and the early stability of implant. However, the porous surfaced implant had weakness from the transgingival contamitants, and it resulted in alveolar bone loss. The other problem identified with porous surface implant is the loss of physical properties resulting from the bead sintering process. In this study, we developed the new bead coating implant to overcome the disadvantages of porous surfaced implant. Ti-6Al-4V beads were supplied from STARMET (USA). The beads were prepared by a plasma rotating electrode process (PREP) and had a nearly spherical shape with a diameter of 75-150 ${\mu}m$. Two types of titanium implants were supplied by KJ Meditech (Korea). One is an external hexa system (External type) and the other is an internal system with threads (Internal type). The implants were pasted with beads using polyvinylalcohol solution as a binder, and then sintered at 1250 $^{\circ}C$ for 2 hours in vacuum of $10^{-5}$ torr. The resulting porous structure was 400-500 ${\mu}m$ thick and consisted of three to four bead layers bonded to each other and the implant. The pore size was in the range of 50-150 ${\mu}m$ and the porosity was 30-40 % in volume. The aim of this study was to evaluate the osseointegration of the newly developed dental implant. The experimental implants (n=16) were inserted in the unilateral femur of 4 mongrel dogs. All animals were killed at 8 weeks after implantation, and samples were harvested for hitological examination. All bead coated porous implants were successfully osseointegrated with peripheral bone. The average bone-implant contact ratios were 84.6 % (External type) and 81.5 % (Internal type). In the modified Goldner's trichrome staining, new generated mature bones were observed at the implant interface at 8 weeks after implantation. Although, further studies are required, we could conclude that the newly developed vacuum sintered Ti-6Al-4V bead coating implant was strong enough to resist the implant insertion force, and it was easily osseointegrated with peripheral bone.
항염증성약물의 치태추출액에 대한 중성호성백혈구의 화학주성 억제효과에 관한 시험관적 연구
우진오,정동균 대한구강생물학회 1980 International Journal of Oral Biology Vol.4 No.1
Inhibition of in vitro neutrophil chemotaxis to the dental plaque extract by a few anti-inflammatory agents was studied in this experiment. For this experiment, the Boyden chamber modified by the author was used. The drugs tested in this experiment were the steroidal anti-inflammatory agent, hydrocortisone succinate, and the non-steroidal anti-inflammatory agents, phenylbutazone and acetylsalicylic acid. The results were as follows ; 1. The neutrophil chemotactic responsiveness to the dental plaque extract diluted 1/1,000 was remarkable. 2. Both steroidal anti-inflammatory agent and nonsteroidal anti-inflammatory agents inhibited the chemotactic responsiveness of neutrophils obtained from the rabbit peritoneal exudates to the dental plaque extract.