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칼시토닌 분비 췌장 내분비 종양을 동반한 다발내분비샘종양 1형 1예
김홍익 ( Hong Ik Kim ),최준혁 ( Jun Hyeok Choi ),오훈규 ( Hoon Kyu Oh ),배성화 ( Sung Hwa Bae ),류헌모 ( Hun Mo Ryoo ),김성규 ( Seong Gyu Kim ),강선미 ( Sun Mi Kang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder characterized by the combined occurrence of tumors of the parathyroid gland, exocrine pancreas, and anterior pituitary gland. Calcitonin-secreting pancreatic endocrine tumors are rare, and calcitonin-secreting pancreatic endocrine tumors with MEN1 have not been reported in Korea. A 46-year-old woman was admitted for a right breast cancer operation. Abnormal blood chemistry findings were hypercalcemia and elevated calcitonin. The patient was diagnosed with a calcitonin-secreting pancreatic endocrine tumor, left thyroid papillary carcinoma, right breast invasive ductal carcinoma, a thymic carcinoid tumor, left adrenal adenoma, uterine myoma, and adenomyosis by computed tomography scan, and with pituitary macroadenoma by brain magnetic resonance imaging. We present this case with a review of the literature, because it is the first reported calcitonin-secreting pancreatic endocrine tumor with MEN 1 in Korea. (Korean J Med 2012;83:817-822)
박성혜 ( Sung Hea Park ),박정신 ( Jeung Shin Park ),홍성연 ( Seong Yun Hong ),김주현 ( Ju Hyun Kim ),오훈규 ( Hun Kyu Oh ),최윤석 ( Youn Seok Choi ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
Uterine leiomyoma is the most frequent gynecologic tumor, but acute torsion of uterine leiomyoma is extremely rare. We report a case of a patient who had suffered lower abdominal pain for 2 weeks. Ultrasonogram showed a subserosal uterine leiomyoma. Laparoscopic surgery confirmed the diagnosis of acute torsion of a subserosal uterine leiomyoma.
자궁경부암 및 상피내암 조직에서의 인유두종바이러스와 Cyclooxygenase 2 과발현의 상관관계
최윤석 ( Youn Seok Choi ),이태성 ( Tae Sung Lee ),김주현 ( Ju Hyun Kim ),김홍태 ( Hong Tae Kim ),오훈규 ( Hun Kyu Oh ),한치동 ( Chi Dong Han ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.8
목적: 자궁경부암 및 자궁경부 상피내암에서 인유두종바이러스 (HPV)와 cyclooxygenase 2 (COX-2) 발현과의 상관 관계를 알아보고자 하였다. 방법: 각각 14명씩의 자궁경부 상피내암, 자궁경부암 환자의 자궁경부 조직과, 대조군으로는 자궁근종으로 자궁적출술을 받은 14명의 환자들의 자궁경부 조직을 이용하였다. 인유두종바이러스 검출에는 중합효소연쇄반응을 이용하였고, COX-2 검출에는 면역조직화학적 염색을 이용하였다. 결과: 고위험군의 인유두종바이러스 감염은 대조군에 비해 상피내암과 자궁경부암에서 현저히 많이 검출되었다 [상피내암: 11예 (78.6%), 자궁경부암: 14예 (100%), 대조군: 1예 (7.1%), P-value<0.001]. COX-2의 발현 강도는 대조군보다 상피내암이 높았고 (P=0.037), 자궁경부암이 상피내암보다 더 높았다 (P=0.002). 인유두종바이러스가 검출되지 않았던 상피내암 3예에서는 바이러스가 검출되었던 나머지 상피내암에 비하여 COX-2의 발현이 현저히 낮게 나타났다 (P=0.013). COX-2의 발현정도와 인유두종바이러스감염과는 유의한 상관관계를 보였으나 (P<0.001), 다변량 분석에서는 정상 조직에서 상피내암, 침윤암으로의 진행만이 COX-2 과발현에 독립적으로 영향을 주는 인자였다. 결론: COX-2의 과발현에는 정상조직에서 침윤암으로의 진행정도가 고위험 인유두종바이러스감염보다 더 중요한 요인으로 추정된다. Objective: The aim of this study was to identify the relation between HPV infection and cyclooxygenase 2 (COX-2) overexpression in cervical carcinoma in situ (CIS) and carcinoma. Methods: Fourteen patients with CIS, 14 patients with invasive cervical carcinoma, and 14 patients with myoma as control were enrolled. Polymerase chain reaction was used to detect high risk types of HPV, and immunohistochemistry was used to detect COX-2 expression. Results: The frequencies of high risk types of HPV infections in CIS or carcinoma were significantly higher than control [CIS: 11 (78.6%), carcinoma: 14 (100%), control: 1 (7.1%), P-value<0.001]. COX-2 expressions in CIS were higher than control (P=0.037), and those in carcinoma were higher than CIS (P=0.002). Three patients with CIS did not show HPV infection and showed lower COX-2 expression than the other patients with HPV infection in CIS group (P=0.013). There was strong correlation between COX-2 expression and HPV infection (P<0.001). However, in multivariate analysis, disease progression from normal to invasive carcinoma was the only independent factor to affect COX-2 overexpression. Conclusion: Disease progression from normal to invasive carcinoma might be more important factor to affect COX-2 overexpression than high risk types of HPV infection.