인동등과 봉독약침이 Adjuvant 투여로 유발된 류마토이드 병태모델에 미치는 실험적 연구

배명현 ( Myung Hyun Bae ),염승룡 ( Seung Ryong Yeam ),김진희 ( Jin Hee Kim ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.1

ObjectivesThis study was carried out to investigate the experimental effects of Lonicerae Caulis and Bee-venom Acupuncture in Yanglingquan (陽陵泉, GB34) that have clinical efficacy in the Rheumatoid Arthritis. MethodsMaterials of present study are Lonicerae Caulis Extracts (LCE), Bee-Venom Acupuncture (BVP), Sprague-dawley rats (250 g or so, ♂), and various kinds of needing experimental studies. We measured several experimental items of the rats with the arthritis induced by Freund``s complete adjuvant (0.2 ml/kg), such as body weight, rate of paw edema, analgesic effect by hot plate method, WBC, TNF-α cytokine and IL-10 cytokine. Rats were divided into four groups; Normal group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to normal rats, Control group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, Experimental group A that was treated with LCE 1.0 ml (o.p) and normal saline 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg and Experimental group B that was treated with LCE 1.0 ml (o.p) and BVP 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, and the experiment took over after 28 days. The results were analysed using SPSS for windows 12.0. ResultsExperimental group A showed the increase in body weight, paw licking times and IL-10 cytokine compared to Control group. Also it was decreased in rate of paw edema, WBC, and TNF-α cytokine compared with Control group. Experimental group B showed the increase in body weight, paw licking times, and IL-10 cytokine compared to Control group, and showed the decrease in rate of paw edema, WBC and TNF-α cytokine compared to Control group. Especially TNF-α cytokine and rate of paw edema were accepted statistical significance compared with Control group. ConclusionsIt is suggested that Lonicerae Caulis (o.p) and Bee-venom Acupuncture (GB34) can be used in the treatment of rheumatoid arthritis. (J Korean Med Rehab 2015;25(1):17-26)

봉독약침이 흰쥐의 국소뇌혈류량 및 평균혈압에 미치는 영향

민선정 ( Seon Jeong Min ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.3

ObjectivesThe present study was designed to investigate the effects of bee venom extract pharmacopunctureon (BVP) at 肩井 (GB21) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanisms. MethodsWe purchased rats about 300g and prepared diluted BVP with normal saline. And we injected diluted BVP to rats gradually progressed from 0.001 mg/kg to 0.1 mg/kg at corresponding region to GB21. After injection, we measured the changes in rCBF and MABP of rats. In addition, to determine the mechanisms of this changes, we did the same experiments twice more after pretreatment with indomethacin and metylene blue separately. ResultsBVP significantly increased rCBF but decreased MABP, suggesting that BVP potently may increase rCBF by dilating pial arterial diameter. Furthermore, the increase of BVP-induced rCBF and the decrease of BVP-induced MABP were significantly blocked by pretreatment with cyclooxygenase inhibitor, indomethacin (1 mg/kg, i.p.). But the increase of BVP-induced rCBF and the decrease of BVP-induced MABP were not blocked by pretreatment with guanylate cyclase inhibitor, methylene blue (0.01 mg/kg, i.p.). ConclusionsThese findings indicate that the action of BVP is mediated by cyclooxygenase. Furthermore these results suggest that BVP can increase rCBF in normal state, as well as improve the stability of rCBF in ischemic state. (J Korean Med Rehab 2013;23(3):37-44)

흰 쥐의 신경병증성 동통 모델에서 봉독약침의 농도별 처치 조건에 따른 치료 효과

박민정 ( Min Jung Park ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.4

목적 :본 실험은 신경병증성 동통에 대한 농도별 처치 조건에 따른 봉독 약침의 치료 효과를 알아보기 위한 연구이다. 방법 :L5 신경을 결찰하여 신경병증성 동통이 유발된 75마리의 흰 쥐 모델을 대상으로 동통 유발 후 7일째부터 이틀에 한번씩, 총 18일 동안 環跳穴(GB30)에 정해진 용량의 봉독약침을 주입하는 방식으로 이루어졌다. 실험을 위해 대조군은 신경병증성 동통 유발 후 동량의 생리식염수만 처치한 군(n=25), 봉독 처치군 Ⅰ은 점진적으로 일정하게 농도를 증가시켜 처치한 군(n=25, 1.67×10-3 mg/kg 부터 8.35×10-3 mg/kg까지, 총 주입량 3.22×10-2 mg/kg), 봉독 처치 군 Ⅱ는 일정하게 농도를 유지시켜 처치한 군(n=25, 3.58×10-3 mg/kg, 총 주입량 3.22×10-2 mg/kg)으로 나누었다. 치료효과를 알아보기 위해 기계적, 열적 자극에 대한 회피반응 역치뿐만 아니라 신경전도속도 검사, 척수후각의 c-Fos 면역조직화학적 반응이 분석되었다. 결과 :실험 결과 기계적, 열적 자극에 대한 통증행동학적 평가와 c-Fos 면역조직화학적 반응에서 봉독 처치군 I은 봉독 처치군 Ⅱ에 비해 봉독약침 처치 초반부터 더 나은 진통효과를 나타냈고, 신경전도속도 검사에서 봉독 처치군 Ⅱ는 봉독 처치군 I에 비해 봉독약침 처치 초반부터 더 나은 신경전도의 회복을 나타냈다. 그러나 처치 후반에는 두 봉독 처치군 모두 비슷한 진통효과를 나타냈다. 결론 :봉독약침 치료는 신경병증성 동통에 매우 효과적임을 알 수 있었고 봉독의 총 처치량이 같은 상태에서 일정하게 봉독의 농도를 증가시키는 방법과 일정하게 봉독의 농도를 유지시키는 방법은 유사한 치료 효과가 있었음을 알 수 있었다.

두통을 동반한 개방성 이관의 한의학적 치료 증례보고

김진희 ( Jin Hee Kim ),민선정 ( Seon Jeong Min ),유경곤 ( Kyung Gon You ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.4

This study was performed to report the case of Korean medical treatment for the Patulous Eustachian tube patient with headache. The patient was treated by acupuncture, herbal medicine, bee venom injection, needle-embedding therapy, chuna therapy, release of cra-nial base and sacro-occipital therapy. Korean medical treatment was administered during 3 weeks. The improvement of clinical symptoms was evaluated by VAS (visual analogue scale) and SF-36 (36-Item Short Form Healthy Survey Instrument). After treatment, most symptoms decreased, headache VAS score changed 10 to 6 and tinnitus VAS score changed 10 to 5. Also, most SF-36 scores increased. Our study suggested that Korean medical treatments are effective in the patient with Patulous Eustachian tube. And further studies are required to identify underlying mechanism of treatment. (J Korean Med Rehab 2013;23(4):261-268)

전골간신경 증후군의 치료증례 보고

민선정(Seon Jeon Min),김진희(Jin hee Kim),김민수(Min Su Kim),염승룡(Seung-Ryong Yeam),권영달(Young-Dal Kwon) 한의병리학회 2014 동의생리병리학회지 Vol.28 No.4

관절강내 봉약침과 매선요법을 병행한 슬개골 재발성 탈구 증례보고

유경곤 ( Kyung Gon You ),김진희 ( Jin Hee Kim ),민선정 ( Seon Jeong Min ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ),이지현 ( Ji Hyun Lee ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.4

The purpose of this study is to observe the effect of Korean medicine treatment in combi-nation with intra-articular bee venom injection and needle-embedding therapy on re-current patellar dislocation in patient. The Patient, diagnosed as recurrent patellar dis-location, was treated by Korean medicine treatment in combination with intra-articular bee venom injection and needle-embedding therapy. Visual analogue scale (VAS), knee flexion range of motion (ROM), Korean Western Ontario and Mcmaster Universities arthri-tis index (K-WOMAC) were used to measure changes during treatment. After treatment, VAS, knee flexion ROM, K-WOMAC were improved significantly. The Korean medicine treatment in combination with intra-articular bee venom injection and needle-embedding therapy was proved to be helpful to improve the symptoms of the recurrent patellar dislocation. (J Korean Med Rehab 2013;23(4):251-259)

안분지신경을 침범한 대상포진의 한,양방 협진 치료 증례

민선정 ( Seon Jeong Min ),박민정 ( Min Jung Park ),유경곤 ( Kyung Gon You ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.4

The purpose of this study is to report the effect of Korean medical treatment in patient with herpes zoster opthalmicus. The patient was treated by acupuncture, herbal medicine, Hwangryunheadok-tang(HuanglianFiedu-Tang) and Ginseng pharmacopuncture, and western medicine from July 25th to August 8th 2012. We measured visual analogue scale(VAS) and observed the change of herpes size through the picture using digital camera. Before this treatment, he took western medicine for 8 days from onset but there was no effect. However, when this Korean medical treatment was finished, VAS score changed from 10 to 1. Korean medical treatment was effective in herpes zoster. But in treating herpes zoster antiviral agents of western medicine might be needed in early stage. And further studies are needed to figure out the effects of Korean medical treatment on herpes zoster.

회전근개 부분파열 환자에 대한 한의학적 치료 증례보고

박민정 ( Min Jung Park ),민선정 ( Seon Jeong Min ),유경곤 ( Kyung Gon You ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ),김성하 ( Sung Ha Kim ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.2

Objectives :This study was performed to report the effect of the conservative oriental medical treatment in the patient with rotator cuff partial tear. Methods :37 year old man lifting heavy package repeatedly was diagnosed with supraspinatus and subscapularis tendon partial tear on left shoulder magnetic resonance imaging(MRI). This patient underwent severe left shoulder pain and range of motion(ROM) limitation. We treated him by acupuncture, a bee venom injection, a herbal medicine, cupping and moxa treatment, physical therapy from January 28th 2011 to April 2nd 2011. Within this treatment period of time, we measured visual analogue scale(VAS), ROM and physical examination changes. Results :After these treatments, shoulder ROM and physical examination recovered signifcantly and static VAS score changed 9 to 0, kinetic VAS score changed 10 to 0.5. Conclusions :In this study, oriental medical treatment was effective in the patient with partial tear of rotator cuff. But this treatment tends to take a long time, so patients with severe pain may give up conservative treatment and choose an operation in a short period of time. Thus, if the more various case studies are reported, patients will follow conservative oriental treatment with confidence.

과체중,비만인 결손가정 소아청소년에 대한 한방 비만 치료 프로그램 적용 사례

박민정 ( Min Jung Park ),민선정 ( Seon Jeong Min ),유경곤 ( Kyung Gon You ),전규상 ( Kyu Sang Jun ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.4

Objectives : The purpose of this study was to investigate the effect of oriental medical treatment on overweight and obese children of broken home. Methods : From July 26 to 30, 2010 and from August 2 to 6, 2010, 17 children were treated in W oriental medicine hospital. Herbal medicine, electroacupuncture, auricular acupuncture, exercise(a gym ball, a jump rope, treadmill etc.), diet therapy and cupping treatment were done daily for four nights and five days. Swimming was done 2 times during this period. Also growth and nutrition education, audio-visual education were done. We checked the change of waist circumference using measuring tape, weight and body composition by bioelectrical impedance analysis(BIA) at the first and the last date of treatment time. SPSS 12.0 ver. for Windowsⓡ was used for statistical analysis of this study. The results of treatment was expressed with mean and ± standard deviation. Results : After this treatment, the weight loss was 2.37±0.76 kg and total fat mass by BIA decreased 1.62±0.87 kg. The waist circumference was decreased 2.11±1.98 cm. Conclusions : Oriental medical treatment for obesity could be effective on overweight and obese chlidren of broken home suffered from untreated. Also, this program of oriental medicine could give proper direction of obesity management.