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다발성으로 발생한 안와 및 두개강내 원발성 배아종 -증례보고-
여인성 ( In Sung Yoe ),이상원 ( Sang Won Lee ),우희경 ( Hee Kyung Woo ),홍재택 ( Jae Taek Hong ),성재훈 ( Jae Hoon Sung ),최승진 ( Seung Jin Choi ) 대한뇌종양학회 2002 대한뇌종양학회지 Vol.1 No.2
We report the unusual case of multiple intraorbital and intracranial germinoma primarily arising from optic nerve, pineal gland extending to the splenium of corpus callosum. The patient was 27-year-old male who presented with progressinve bilateral visual loss for 2yrs and suddenly developed right painful exothalmus. The neuroimaging studies disclosed tumors in the right optic nerve, optic chiasm, pineal gland and posterior corpus callosum. The tumor markers of serum and cerebrospinal fliud were all negative. The intraorbital and intracranial optic nerve tumor was removed via fronto-orbitotomy and pterional approach. The histological diagnosis was germinoma. Follow up brain MRI demonstrated complete disappearance of the multiple masses after completion of three courses of combinant chemotheraphy with Ifosfamide-Cisplatin-Etoposide. This case is believed to be the first case report as multiple intraorbital and intracranial primary germinoma.