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Di(n-butyl) Phthalate가 태자와 신생자 SD Rat의 면역계 발생에 미치는 영향
정승태(Seung-Tae Chung),엄준호(Juno Ho Eom),박재현(Jae Hyun Park),정형진(Hyung-Jin Chung),황인창(In-Chang Hwang),김동섭(Dong Sup Kim),하광원(Kwang Won Ha),김형수(Hyung Soo Kim) 한국독성학회 2001 Toxicological Research Vol.17 No.2
Some of endocrine disruptors with sexual hormone-like effects have been increasingly reported to be immunotoxic in many species in recent several years. Phthalate esters have possible effects on the endocrine system. Prenatal exposure to di(n-butyl) phthalate (DBP) has been reported to impair the androgen-dependent development of the male reproductive tract in rat. Therefore, the immunomodulatory effect of DBP was investigated in the developing immune system of fetal and neonatal Sprague-Dawley rats. Timed-bred pregnant SD rats were given to the doses of 0, 250, 500, and 750 mg DBP/kgㆍbody weight/day by gavage once a day from gestational day (GD) 5 to 18. On GD19 or GD22/postnatal day one (PD1), the dams were euthanized, and the changes in organ weights and thymus phenotypes were examined their offsprings. At 750 mg DBP/kg ㆍb.w./day in maternal exposure group, GD19 fetuses showed decreases in body weight. The spleen/body weight ratios were reduced in GD19 fetuses from the dams exposed to 500 and 750 mg DBP/kgㆍb.w./day. There were no significant changes in thymus and spleen cellularities though these cellularities showed a tendency to decrease in a dose dependent way. In the DBPGD22/PDl offsprings, the body weights, the relative organ weights and the cellularities did not exhibit alteration. Additionally, the percentages of CD3+(CD4+CD8+, CD4+CD8-, CD4-CD8+, and CD4-CD8) and CD3-(CD4+CD8+, CD4+CD8-, CD4-CD8+, and CD4-CD8) thymocyte subsets were not changed in any DBP-treated group. The proliferative responses oj splenic T cells to Con A and B cells to LPS were decreased in all DBP-exposed GD22/PDl offsprings.
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