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수막혈관종증과 연관되어 발생한 침윤성 수막종 -증례보고-
섲주용 ( Joo Yong Seong ),이일우 ( Il Woo Lee ),양지호 ( Ji Ho Yang ),이진석 ( Jin Seok Yi ),이형진 ( Hyung Jin Lee ),이혜경 ( Hye Kyung Lee ),양보성 ( Po Song Yang ) 대한뇌종양학회 2003 대한뇌종양학회지 Vol.2 No.1
The authors present the case of a 9-year-old female patient with meningioma at left temporal area originationg from underlying meningioangiomatosis. The patien manifested complex partial seizure as the initial symptom. She had no stigmata of neurofibromatosis Type 2. Neuroradiological studies revealed an extraxial, contrast-enhancing lesions at left temporal lobe. After gross total removal of the tumor, histokogical examination revealed invasive meningioma with surrounding meningioangiomatosis. Although there were no signs of anaplasia, necrosis, or increased mitosis, tumor islands were observed in the adjacent brain parenchyma. The rare association of meningioangiomatosis and meningioma is discussed along with radiological and surgical findings.
약물 복용력이 없는 주의력결핍 과잉행동장애 아동에서의 뒤쪽 내정상태회로 이상
최지욱(Jeewook Choi),고효진(Hyo Jin Go),우영섭(Young Sup Woo),송승훈(Seung Hoon Song),양보성(Po Song Yang),정범석(Bumseok Jeong) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.2
Objectives:Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. Methods:Twenty medication-naive children with ADHD (mean age 10.3±2.5) and 28 age- and gender-matched healthy volunteers (mean age 10.3±2.0) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. Results:Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). Conclusion:An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.