우울증 및 불안장애 환자에서 특성불안 차이에 따른 긍정심리요인의 특징

안희영,민정아,김선영,채정호,An, Hee-Young,Min, Jung-Ah,Kim, Sun-Young,Chae, Jeong-Ho 대한불안의학회 2013 대한불안의학회지 Vol.9 No.1

Objective : The aim of this study was to investigate the relationship between trait anxiety and positive psychological factors. Methods : A total of 429 outpatients diagnosed with depression and/or anxiety disorders surveyed with questionnaires measuring socio-demographic, clinical, and positive psychological factors. The relationships of trait anxiety with clinical symptoms and positive psychological factors were evaluated. Results : Patients with low trait anxiety showed high optimism, gratitude, hope, spirituality and purpose in life. After adjusting age, scores of BDI and STAI-S, the results showed low trait anxiety was associated with high spirituality and purpose in life. Conclusion : The result revealed that trait anxiety had negative-relationship with spirituality and purpose in life in patients with depressive and/or anxiety disorders. Although trait anxiety was known as a general tendency which is stable, approach to trait anxiety by modulating these associated positive psychological factors would be newer approach of treatment to patients with depressive and/or anxiety disorders.

지대치 연결고정에 따른 편측성 후방연장 국소의치에서의 응력분포

안희영,진태호,Ahn Hee-Young,Jin Tai-Ho 대한치과보철학회 2004 대한치과보철학회지 Vol.42 No.2

Statement of problem: In distal extension removable partial denture, the preservation of health of abutment teeth are very important, but they are always subjected to unfavorable stress. Purpose: The purpose of this study was performed to investigate the effects of abutment splinting and design of direct retainer on the stress distribution of abutments in unilateral distal extension removable partial dentures. Material and method: Abutments were splinted by different method. In group 1, autment teeth were not splinted, in group 2, canine and 1st premolar were splinted, and in group 3, canine, 1st and 2nd premolars were all splinted. Three different types of direct retainer such as Akers clasp, RPI clasp, and wrought wire clasp were designed. Strain was measured with Switch & Balance Unit(SB-10, Measurement Group Instruments Division, Raleigh USA) and Strain Indicator(P-3500, Measurement Group Instruments Division, Raleigh, USA) 15kg of vertical and oblique loads was applied at central fossa of missing 2nd molar area. Results : The strain on lingual side of 2nd premolar was the greatest, and abutment splinting induced decrease of strain on buccolingual side of 2nd premolar. The strain of loaded area was decreased by abutment splinting and there was no statistical difference of strain between Group2 and Group 3, and strain on 2nd premolar in wrought wire clasp was the least. Conclusion: Within the limitations of this study, splinting of two distal abutment teeth is enough for stress distribution widely, and wrought wire clasp was more benefitable than others.

편측후방연장 국소의치에서 인상채득 방법과 클라스프 설계에 따른 지대치의 응력분석에 관한 연구

안희영,김광준,조혜원,진태호,Ahn Hee-Young,Kim Kwang-Jun,Cho Hye-Won,Jin Tai-Ho 대한치과보철학회 2001 대한치과보철학회지 Vol.39 No.5

This study was performed tn investigate the effects of impression method and design of the retainer on the stress of abutment tooth in distal extension RPD. Three different types of direct retainer such as Akers clasp, RPI clasp, and wrought wire clasp were designed. Stress on the abutment tooth was measured and analyzed with strain gauge method. Impressions were anatomic impression technique and functional impression technique. The following conclusions were drawn from this study. 1. The stress at the abutment tooth on all RPD was decreased in functional impression except RPI clasp retained RPD. 2 The stress at the abutment tooth on RPI clasp retained RPD was the most smallest in anatomic Impression. 3. While load is increase the stress at the abutment tooth was increased, but the change of stress at the buccal side of abutment tooth was not too much in functional impression.

기업설명회가 자기자본비용에 미치는 영향

안희영(Ahn, Hee-Young),최성호(Choi, Sungho) 대한경영학회 2011 大韓經營學會誌 Vol.24 No.6

기업의 사회적 책임 활동이 자본비용에 미치는 영향

안희영(Hee-Young Ahn),최성호(Sungho Choi) 대한경영학회 2015 大韓經營學會誌 Vol.28 No.8

바이오센서용 Au/TiO2/CNT 나노복합체의 전기화학적 특성

안희영 ( Hee Young An ),박수길 ( Soo Gil Park ) 충북대학교 산업과학기술연구소 2009 산업과학기술연구 논문집 Vol.23 No.2

This study is to enhance the sensitivity of CNT electrode by coating metal nanoparticles in biosensor. To improve electric conductivity and wettability, Au and TiO2 nanoparticles were coated on CNT, respectively. And then the Au and the TiO2 nanoparticles were attached to the CNTs surface by sonication for reduction of Au and by calcination for oxidation of Ti. The physical properties of Au/TiO2/CNT nanocomposites was observed by SEM. TEM and XRD. The electrochemical characteristics of Au/TiO2/CNT nanocomposites were performed by CV. It was observed by CV that the electrode of Au/TiO2/CNT nanocomposites was more sensitive than that of CNT, Au/CNT and TiO2/CNT.

Effect of Cordycepin-Enriched Cordyceps militaris Powder on Tissues Lipid Peroxidation and Antioxidative Activity in Orotic Acid-Induced Fatty Liver Model Rats

안희영(Hee-Young Ahn),차재영(Jae-Young Cha),허수진(Su-Jin Heo),강민경(Min-Jeong Kang),이재홍(Jae-Hong Lee),박상현(Sang-Hyun Park),조영수(Young-Su Cho) 한국생명과학회 2011 생명과학회지 Vol.21 No.10

눈꽃 동충하초, 번데기 동충하초, Cordycepin 고함유 번데기 동충하초 분말을 식이 중에 각각 3% 수준으로 첨가하여 10일간 흰쥐에 급여한 후 임상생화학적 특성 및 조직 내 항산화 활성 및 간 조직에 미치는 영향을 검토하였다. 체중 증가량과, 식이 섭취량은 각 실험군 모두 감소 하였으나, 음료 섭취량은 증가하였다. 간 손상 임상지표인 AST, ALT, LDH, ALP 활성도 각 실험군 모두 저하하였으며, 대조군과 비교하여 간 조직의 상대 중량도 감소하였다. 각 조직과 혈청의 과산화지질(TBARS)을 측정한 결과 대조군에 비해 각 실험군에서 유의적으로 감소하였으며, 그 중 Cordycepin 고함유 번데기 동충하초 분말을 투여한 군에서 가장 낮은 함량을 보였다. 특히 Cordycepin 고함유 번데기동 충하초는 간장 조직 내에서 높은 과산화지질 억제작용을 나타내어 조직 내 항산화 물질로 잘 알려진 glutathione농도 또한 대조군에 비해 높은 함량을 보였다. 간장 내 지방산화를 촉진하는 Fe와 생체내 항산화물질로 잘 알려진 Zn을 측정한 결과 동충하초 첨가 식이를 섭취한 군에서 증가하였다. 이상의 실험 결과 Cordycepin 고함유 번데기 동충하초는 항 동맥경화 작용 뿐만 아니라 간 조직 내 항산화 물질 증가에 의한 산화스트레스를 경감시킴으로써 향후 간 독성 개선 효능을 가지는 건강기능식품 개발의 소재로 활용될 가능성이 높은 것으로 판단되어 진다. This study is aimed to evaluate the protective effect of Cordycepin-enriched Cordyceps militaris (CMα) strain on orotic acid (OA)-induced fatty liver in rats. OA treatment induced the retardation of body weight gain and enlargement of the liver. The activities of liver marker enzymes, alanine amino-transferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), Alk. phosphatase and Cholinesterase were increased when treated with OA, but these parameters were significantly decreased in the CMα group. The current study observed significant elevations of thiobarbituric acid-reactive substance (TBARS) levels. However, among the OA groups, the CMα group showed significantly low TBARS levels of hepatic homogenate. The OA group resulted in a significant decrease in the levels of plasma and hepatic glutathione, but these reductions were significantly increased in the CMα group. These effects were more pronounced in the CMα group than in the PJ or CM groups in Orotic acid treated rats. Accordingly, Cordycepin-enriched Cordyceps militaris (CMα) may be an ideal candidate for hepatoprotective effects in animal models.

곰팡이 발효 가시오가피의 이화학적 특성과 생리활성

안희영(Hee-Young Ahn),차재영(Jae-Young Cha),조영수(Young-Su Cho) 한국생명과학회 2012 생명과학회지 Vol.22 No.12

미생물 발효에 의한 부위별 가시오가피의 생리활성 작용 및 물질을 개발하기 위한 기초 자료를 얻을 목적으로 Aspergillus oryzae KCCM 11372, Aspergillus kawachii KCCM 32819, Monascus purpureus KCCM 12002 3종의 곰팡이 균주를 본 실험에 사용하였으며, 이들에 의한 부위별 발효 가시오가피의 폴리페놀, 플라보노이드와 미네랄 함량, 지방산 조성, 항산화 활성, 미백 효능을 비교 검토하였다. 곰팡이 균주로 발효시킨 분말의 pH범위는 3.9-6.97 였으며, 미네랄 성분 조성 비율은 Ca, K, Mg 순으로, 각 곰팡이 균주 발효에 의한 발효 가시오가피 분말의 미네랄 함량은 전체적으로 발효된 분말이 발효 전 분말보다 함량이 높았다. 주요 지방산 조성은 palmitic acid, stearic acid, oleic acid 으로 전체적으로 포화지방산이 대부분을 차지하고 있었다. 항산화 활성은 가시오가피 줄기에서 발효전 분말은 약 27%의 활성을 나타냈지만 M. purpureus와 A. oryzae 균주로 발효시킨 분말은 약 73%와 61%로 활성이 증가했다. 또한, 가시오가피 열매도 발효전 분말은 약 58%의 활성을 나타냈지만 M. purpureus와 A. oryzae 균주로 발효시킨 분말은 약 77%와 69%로 활성이 증가했다. 미백 효능은 가시오가피 잎, 뿌리, 줄기, 열매는 약 20% 이하로 매우 낮은 수준이었지만 가시오가피 잎과 뿌리에서 발효에 의해 활성이 증가하는 경향을 보였다. 이상의 실험결과에서 곰팡이 균주에 의한 부위별 발효 가시오가피의 생리활성 효과 및 이화학적 특성이 발효 전 가시오가피 분말보다 강화됨으로써 건강기능식품이나 화장품의 천연 항산화제 소재로서의 이용 가능성이 높다고 할 수 있다. Three mold strains, Aspergillus oryzae (A. oryzae), Aspergillus kawachii (A. kawachii), and Monascus purpureus (M. purpureus), were tested for fermentation of Acanthopanax senticosus (A. senticosus) leaf, root, stem, and fruit powders. The fermented A. senticosus materials were then tested for bioactive materials (phenolic compounds, flavonoids, mineral and fatty acid) and biological activities (DPPH free radical scavenging activity, reducing power, and tyrosinase inhibition activity). The highest concentrations of phenolic compounds and flavonoids were NFASL at 4.11% and MPASL at 2.30%, respectively. Major minerals were Ca, K, Mg and Mn. Major fatty acids in fermented A. senticosus powders were palmitic, linolenic, and stearic acids. DPPH radical scavenging activity was slightly stronger in non-fermented than in fermented A. senticosus. Tyrosinase inhibition activity was stronger in fermented A. senticosus than in NFAG. The Fe/Cu reducing powers were stronger in non-fermented A. senticosus than in any of the fermented A. senticosus materials. Overall, the study provides basic data for understanding the biological activities and chemical characteristics of A. senticosus fermented by molds for the development of functional foods.

측백나무 잎ㆍ열매 추출물의 이화학적 특성 및 항산화 효과

Hee-Young Ahn(안희영),Su-Jin Heo(허수진),Min-Jung Kang(강민정),Jae-Hong Lee(이재홍),Jae-Young Cha(차재영),Young-Su Cho(조영수) 한국생명과학회 2011 생명과학회지 Vol.21 No.5

측백나무 잎 및 열매 물, 에탄올 및 메탄올 추출물의 생리활성 물질(총 폴리페놀 화합물, 플라보노이드, 미네랄, 지방산 조성) 분석과 항산화 활성(DPPH free radical scavenging 활성, Cu/Fe-환원력, 간 조직 microsome 생체막 및 linoleic acid 과산화지질)을 측정하였다. 측백나무 잎의 메탄올 추출물에서 추출 수율(12.90%), 폴리페놀 화합물(16.02%) 및 플라보노이드(0.25%) 함량이 가장 높았다. 측백나무 잎 및 열매의 주요 미네랄은 Ca, K, 및 Mg이었다. 측백나무 잎의 주요 지방산은 palmitic acid 및 lauric acid였으며, 열매는 palmitic acid 및 decanoic acid가 높은 함량을 보였다. DPPH free radical scavenging 활성, Cu/Fe-환원력, 간 조직 microsome 생체막 및 linoleic acid의 과산화 지질 측정에 의한 항산화 활성은 측백나무 열매보다는 잎 추출물에서 높았으며, 시료 처리 농도 의존적으로 활성이 증가되는 것으로 나타났다. 이상의 실험 결과에서 측백나무 잎의 메탄올 추출물에서 높은 항산화 활성이 있었으며, 이는 폴리페놀 화합물과 플라보노이드와 같은 항산화 활성을 나타내는 생리활성 성분을 많이 함유하고 있는 것으로 나타나 향후 건강기능식품이나 화장품의 천연 항산화제 소재개발에 유용하게 사용될 것으로 사료된다. The contents of bioactive materials (e.g. polyphenolics compounds, flavonoids, minerals, and fatty acids) and antioxidative activities (DPPH (α,α'-diphenyl-β-picrylhydrazyl) free radical scavenging activity, peroxidation of linoleic acid and rat hepatocyte microsome, and Fe/Cu reducing power) were tested by in vitro experimental models using water, ethanol and methanol extracts of leaves (TOL) and fruits (TOF) from Thuja orientalis. Methanol extract from TOL showed the highest extraction yield (12.90%) as well as contents of polyphenolic compounds (16.02%) and flavonoids (0.25%). Major minerals were Ca, K, and Mg. Major fatty acids were palmitic and lauric acids in TOL and palmitic and decanoic acids in TOF. In oxidation of in vitro models using DPPH free radical scavenging activity, Fe/Cu reducing power, Fe²?/ascorbate-induced linolenic acid peroxidation by ferric thiocyanate and thiobarbituric acid (TBA) methods, and autooxidation of rat hepatic microsomes membrane, antioxidative activities were stronger in all extracts of TOL than in those of TOF in a dose-dependent manner. From these results, methanol extract of TOL was shown to have the most potent antioxidative properties and the highes content of antioxidative compounds such as polyphenolic compounds and flavonoids.

발효 와송 급여 흰쥐의 orotic acid 유발 지방간 개선 효과

안희영(Hee-Young Ahn),최다정(Da-Jeong Choe),조영수(Young-Su Cho) 한국생명과학회 2015 생명과학회지 Vol.25 No.8

와송과 유산균 발효 와송을 식이 중에 2.5% 및 5.0% 수준으로 첨가하여 10일간 흰쥐에 급여하고, orotic acid 유발 비알코올성 지방간을 일으켜 임상생화학적 특성 및 조직 내 항산화 활성 및 간 조직에 미치는 영향을 검토하였다. OA군은 간 기능 지표 효소인 혈중 AST, ALT, ALP, cholinesterase, LDH 활성에서 모두 높은 활성을 나타내었지만, OM군과 FOM군은 활성이 감소하여 N군과 유사한 수치를 나타내었다. 또한 유의적으로 큰 차이는 보이지 않았지만 OM군보다 FOM군이 더 낮은 수치를 보였으며, 농도의존적으로 감소하는 경향을 보였다. 특히 LDH에서 5FOM군은 N군보다 더 낮은 활성을 나타내었다. OA군은 간 조직의 분획물, 고환, 신장, 비장의 TBARS의 함량이 증가하였지만, OM군과 FOM군에서 감소하는 경향을 보였으며 특히 5FOM군에서 유의적으로 낮은 결과를 나타내었다. 장기 내 존재하는 glutathione의 함량 또한 OA군이 N에 비해 낮은 수치를 보였으나, OM군과 FOM군에서 농도의존적으로 증가하는 경향을 나타내었다. 특히, 5FOM군에서 N군에 상응하는 높은 수치를 보였으며, 비장과 심장에서는 N군보다 높은 수치를 나타내었다. 이상의 실험결과로 유산균 발효 와송은 orotic acid 유발 비알코올성 흰쥐 지방간에 대한 개선 효과를 보여 간 기능 개선에 효과적인 건강식품 소재로서 가능성을 보였다. This study aimed to evaluate the protective effect of Orostachys malacophyllus (OM) and fermented O. malacophyllus (FOM) in Sprague-Dawley rats who had been intoxicated with 1% (w/w) orotic acid (OA) for 10 days. The activities of several hepatic enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and cholinesterase, were increased when OA was given, but these parameters were significantly decreased by FOM treatment. In addition, OA treatment resulted in an increased lipid peroxidative index (thiobarbituric acid-reactive substances, TBARS). A worsened antioxidant status (reduced glutathione) in the liver and serum was also observed. FOM treatment improved the antioxidant status of OA-induced fatty-liver rats, which was evaluated by decreased levels of the lipid peroxidative index and improved antioxidant status in the liver and serum. The contents of liver non-heme iron were increased with OA treatment and significantly decreased with FOM treatment, which suggested that the lipid peroxidation contents were inversely correlated with liver non-heme iron content. Based on these results, FOM is considered a material with significant potential for development into a functional health food that can improve fatty-liver conditions.