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- 저자 : 신미영(Mee-Young Shin) (검색결과 4 건)
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신미영(Shin, Mee-Young),권인숙(Kwun, In-Sook) 한국영양학회 2016 Journal of Nutrition and Health Vol.49 No.1
Purpose: Zinc, a biomineral present within and outside cells, manages various cellular mechanisms. In this study, we examined whether zinc was involved in vascular smooth muscle cell (VSMC) calcification via regulation of calcification inhibitor protein, osteopontin (OPN). Methods: Rat aorta cell line (A7r5 cells) and primary vascular smooth muscle cells (pVSMCs) from rat aorta were cultured with phosphate (1-5 mM) and zinc (0-15 μM) as appropriate, along with osteoblasts (MC3T3-E1) as control. The cells were then stained for Ca and P deposition for calcification examination as well as osteopontin expression as calcification inhibitor protein was measured. Results: Both Ca and phosphate deposition increased as the addition of phosphate increased. In the same manner, the expression of osteopontin was upregulated as the addition of phosphate increased in both cell types. When zinc was added, Ca and P deposition decreased in VSMCs, while it increased in osteoblasts. Conclusion: The results imply that zinc may prevent VSMC calcification by stimulating calcification inhibitor protein OPN synthesis in VSMCs.
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신미영(Shin, Mee-Young),권인숙(Kwun, In-Sook) 한국영양학회 2016 Journal of Nutrition and Health Vol.49 No.1
Purpose: The aim of this review is to comprehensively summarize the definition of vitamin D as a nutrient as well as a hormone-like molecule and its new function in prevention of various chronic diseases. Methods: The review was written by the method for systematic reivew writing. Literatures from the various sources, including research articles, book chapters, proceedings and electronic materials as appropriate, were screened first and then reviewed and analyzed for the review. Results: Vitamin D was originally considered as the essential nutrient as a vital carbon compound and was first discovered among children with osteomalacia, also known as ricket disease, characterized by poorly calcified bones which were easily bent rather than broken. Since that time, vitamin D has been known as the key nutrient to improve bone health. However, recently emerging study findings have shown that vitamin D acts as the hormone-like nutrient since it is synthesized like a hormone when our body needs and this particular vitamin also acts like a cell signaling ligand which regulates gene expression of various proteins. So far positive effects of vitamin D have been suggested for the action of anticancer, antiimmune function, and anti-cardiovascular disease, as well as antidiabetic function, etc. In this review, the definition for vitamin D as a nutrient vitamin as well as a hormone-like molecule, cell signaling mechanism of vitamin D, and finally the potential role for the prevention of chronic diseases are discussed. Conclusion: Vitamin D is now being considered as a vital nutrient as a vitamin and as a potential substance for prevention of several chronic diseases.
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과망간산칼리에 의한 어류 아가미의 병리조직학적 변화와 수질에 따른 영향
최동림(Dong Lim Choi),정준기(Joon Ki Chung),전세규(Seh Kyu Chun),신미영(Mee Young Shin) 한국어병학회 1993 한국어병학회지 Vol.6 No.1
Histopathological changes in gills by potassium permanganate were investigated in four fish species. flounder(Pararychthys olivaceus) and rockfish(Sebastes schlegeli) in marine fish, and carp(Cyprinus carpio) and eel(Anguilla japonica) in freshwater fish. Marine fishies were more sensitive to KMnO₄ than freshwater fishies and have shown histological changes even in low concentration of 1ppm. Eels were less affected than carp in high concentration of KMnO₄. Especially in eels, hyperplasia and hypertropy of mucus cells were observed. Compared to in underground water. the effect of KMnO₄ were reduced very much in pond water. That this differences were due to the concentration of organic substances were certained by experiment with various feed concentrations. The potency of KMnO₄ were influenced by dissolved oxygen.
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