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하루 4회 인슐린 투여에 의한 모성 당뇨 환자에서의 과혈당 조절 3례 보고
임대훈(D.H. Lim),윤정묵(J.M. Yoon),이상은(S.E. Lee),김종필(J.P. Kim),송경민(K.M. Song),황성욱(S.W. Hwang),고승권(S.K. Ko),조숙(S. Cho),이우영(W.Y. Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
Insulin therapy is indicated in the treatment of gestational diabetic women and pregnant overt diabetic women for hyperglycemia after failure to respond to the diet and exercise regimen. If both the fasting and postprandial glucose levels are elevated or if a women's postprandial glucose levels can only be blunted if starvation ketosis occurs, a four-injection-per-day regimen of insulin is prescribed. The insulin is administered to mimic normal pancreatic function. The normal pancreas secretes 50 % of the insulin as mealtime boluses. This delivery may be mimicked by four-injection-per-day of combination of NPH and regular insulin. 6 or more glucose measurements each day may be required to optimize therapeutic effect and ensure a smooth increase of insulin as the pregnancy progresses to a higher insulin requirement. Here we report 3 cases of hyperglycemic control with four times daily administration of insulin on diabetes in pregnancy, with brief reviews.