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최유진,서효령,윤유진,이경진,김동광,김상희,이병훈 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Non-alcoholic fatty liver disease is associatedwith inhibited AMP-activated kinase (AMPK) and activationof sterol regulatory element binding protein 1(SREBP-1). AMPK phosphorylation inhibits SREBP-1, amajor transcription factor of de novo lipogenesis, byinhibiting the liver X receptor (LXR) or by direct phosphorylation. Resveratrol, a polyphenol, has regulatoryeffects on hepatic lipid metabolism as a potent AMPKactivator. In this study, we evaluated the anti-steatogeniceffects of resveratrol and its derivatives and identified themolecular mechanism in vitro and in vivo. Resveratrol andits derivatives decreased lipid accumulation by free fattyacids (FFA mixture; 0.5 mM, oleic acid:palmitic acid = 2:1) in H4IIEC3 cells. Synthesized derivatives of resveratrolhad lower cytotoxicity than the parental molecule withsimilar potency. SY-102 suppressed SREBP-1 maturationby T0901317, an LXR agonist, and decreased SRE luciferaseactivity and the mRNA levels of lipogenic genes. Inhibition of AMPK by pre-treatment with compound Ccompletely blocked the effects of SY-102. To evaluatetheir efficacy in vivo, mice were fed a high-fat diet for5 days, and resveratrol or SY-102 was administered orallyfor the last 2 days. Oral administration of the SY-102increased AMPK phosphorylation, followed by reducedhepatic triglyceride accumulation to a similar extent asresveratrol. These data demonstrate that SY-102, a synthesized derivative of resveratrol, might provide apromising therapeutic effect against fatty liver disease.
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