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서창희 ( Chang Hee Suh ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.2
B cells play an important role in the pathogenesis of autoimmune disease. B cells not only produce pathogenic autoantibodies, but also present self-antigens to T cells and provide costimulatory signals for self-reactiveT cells. Recently, biologics have been tried in several autoimmune diseases as immune modulators with some promising results. Among them, several biologic agents that target B cells have led to improved patients` outcomes and quality of life in patients with rheumatoid arthritis and systemic lupus erythematosus. These agents either deplete B cells by targeting B cell surface antigens, such as CD20 and CD22, or block B cell survival by inhibiting the activity of B cell survival factors, such as BLyS and APRIL. Initially, I discuss briefly the role of B cells in driving autoimmune diseases, and then focus on the efficacy and safety data of the B cell-targeted therapy in rheumatoid arthritis and systemic lupus erythematosus.
초고강도 소재가 적용된 U 형 채널 제품의 다단공정변수에 따른 스프링백 영향
서창희(Chang Hee Suh),정윤철(Yun-Chul Jung),임용희(Yong Hee Lim),윤효윤(Hyo Yun Yun),이경훈(Kyunghoon Lee),김영석(Young Suk Kim) 대한기계학회 2012 大韓機械學會論文集A Vol.36 No.3
자동차 부품의 경량화를 위해서 초고강도강의 사용이 확대됨에 따라 판재성형 공정에서 초고강도강판의 스프링백 제어의 중요성이 점차로 확대되고 있다. 본 연구에서는 초고강도 소재를 사용한 U 형 채널 부품의 성형을 위해서 사용되는 다단공정에서 공정 변수들이 스프링백에 미치는 영향에 대하여 검토하였다. 해석을 위해서는 유한요소법이 사용되었으며, 주요 공정 변수는 공정수, 금형 각도, 금형 반경, 펀치성형방향이다. 단공정에 비해서 다단공정이 스프링백을 아주 효과적으로 제어할 수 있었으며, 금형반경과 펀치성형방향의 각도가 작을수록 스프링백 제어에 효과적이었다. 그러나 금형 각도의 영향은 크지 않았다. Ultra-high-strength steels (UHSSs) are widely used for lightweight automobile parts, and the control of springback is very important in sheet-metal forming. The object of this study is to verify the effects of multi-stage forming process parameters for U-channel-type automobile parts made of UHSS. Finite element analysis is carried out to predict the formability and springback. The main parameters considered for the multi-stage forming process are the die angle, die radius, and punch-forming direction. It is shown that multi-stage forming is very effective for reducing springback, and that a small punch-forming angle and die radius reduce springback, whereas the die angle does not have a large effect.
보론강판이 사용된 용접조인트의 입열량에 따른 기계적 특성 변화
서창희(C. H. Suh),이락규(R. G. Lee),정윤철(Y-C. Jung),박종규(J. K. Park),김양수(Y. S. Kim),김영석(Y. S. Kim) 한국소성가공학회 2010 한국소성가공학회 학술대회 논문집 Vol.2010 No.10
To apply boron steel to chassis parts in automobiles, weldability with dissimilar materials is required, as well as formability during hot stamping. Accordingly, this study investigated the effect of the welding heat input on the mechanical properties and the fatigue life of a quenched boron steel and ferrite-bainite (FB) steel lap joint. It was found that, the higher the welding heat input at the weld metal and boron steel HAZ, the lower the hardness. However, at the FB steel HAZ, the hardness was not significantly changed by the welding heat input. Plus, the high hardness of the weld metal and boron steel HAZ prevented the initiation of cracks in the stress concentration area around the bead. While the fatigue life was affected by the residual stress, the variation of the welding heat input used in this study had hardly any affect on the residual stress. Nonetheless, the fatigue life was affected by the bead geometry that changed according to the welding heat input. Thus, for the lap joint, the bead geometry was a significant parameter affecting the fatigue life, which increased when increasing the bead width.