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전자빔을 이용한 폴록사머 하이드로젤의 제조 및 구강 점막부착성 약물전달을 위한 특성 분석
백은정(Eun Jung Baek),신백기(Baek Ki Shin),노영창(Young Chang Nho),임윤묵(Youn Mook Lim),박종석(Jong Seok Park),박정숙(Jeong Sook Park),허강무(Kang Moo Huh) 한국고분자학회 2012 폴리머 Vol.36 No.2
본 연구에서는 전자빔을 이용하여 폴록사머 하이드로젤을 제조하여 구강 점막부착성 약물전달체로서의 특성을 평가하고자 하였다. 온도감응성을 나타내는 폴록사머 고분자의 말단에 가교반응을 위한 비닐기를 도입 한 후, 방사선 가교반응을 이용하여 하이드로젤을 제조하였다. 점착성 향상을 위한 첨가제로 점착성 고분자인 카 보폴을 첨가하여 하이드로젤을 제조하였고, 카보폴이 점막부착성과 서방성 방출에 미치는 영향을 알아보았다. 결과적으로, 폴록사머 고분자의 말단 개질과 카보폴의 첨가에 의해 하이드로젤의 기계적 물성과 점막부착성이 향상되었고, 약물방출실험 결과 약물이 방출되는 속도가 지연되는 결과를 확인하였다. In this study, poloxamer hydrogels were prepared by electron beam irradiation and evaluated for potential application as a buccal mucoadhesive drug delivery system. Poloxamer, one of typical thermoresponsive polymers, was modified to have vinyl end groups for crosslinking reaction, and its hydrogels were fabricated by irradiation crosslinking reaction. Carbopol as a mucoadhesive polymeric additive was introduced to improve the mucoadhesive property of the hydrogels and its effect on the mucoadhesion and drug release properties was investigated. The results showed that the end group modification of poloxamer and the addition of carbopol improved mucoadhesive force and mechanical properties and led to a sustained drug release behavior.
백종범(Jong Bum Baek),성승훈(Seung Hoon Seong),원달연(Dal Yeon Won),배금석(Keum Seok Bae),김익용(Ik Yong Kim) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.6
Purpose: Spontaneous hemoperitoneum is not a common disease but may cause a fatal outcome. Warfarin is a coumarin anticoagulant, used widely for therapeutic and prophylactic anticoagulation. Although, it is considered a life saving medicine, it is associated with significant adverse effects including intraabdominal bleeding. Literatures about spontaneous hemoperitoneum in patients taking anticoagulants have been reported, but until now there have not been a definite establishment in diagnostic criteria and treatment strategy. Methods: Among 209 patients who were diagnosed hemoperitoneum from Jan 2005 through May 2009, we identified 9 patients with spontaneous hemoperitoneum without any trauma history or solid organ abnormalities. All 9 patients were taking warfarin for various durations. Initially, we evaluated vital signs, laboratory, CT findings, and clinical course, retrospectively. In addition, we analyzed risk factors potentiating the pharmacologic effect of anticoagulants. Results: One of the most prominent features in this study is that all patients showed prolonged international normalized ratio (6.36∼15.11). One patient received an exploratory laparotomy for hemoperitoneum secondary to warfarin, presenting as a localized peritonitis in the right lower quadrant of the abdomen. Mean hospital stay was 15.2 days. Five patients were transfused with packed red blood cells (500∼1,000 ml) and fresh frozen plasma (300∼900 ml). All patients were discharged without any mortality. Conclusion: It is important to identify and confirm the factors that can potentiate the pharmacologic effect of anticoagulants, when acute abdomen is suspected in patients taking anticoagulants. If the patients are hemodynamically stable, they can be treated without surgical intervention.
외국인근로자 정책 및 법제개선에 관한 연구 - 독일의 외국인근로자 법제를 중심으로 -
백종인 ( Jong In Baek ),설재영 ( Jae Young Seol ) 고려대학교 법학연구원 2007 고려법학 Vol.0 No.49
Korea is going to be faced with the aging society within years. That means our society will lack of economically active population because of an increase in the number of older people soon. The age composition of Korea is expected to move from one of mainly young people who can work to one in which the number of older people will outnumber the young. it is also expected that by 2050 the number of aged people will be doubled compared with the young. We can not help overcoming this problem through foreign workers. So Korea took "the foreign industrial trainee system" to accept the international movement of human capital and then has operated this system with changing into working permit system since August 2004. Germany had experienced the need of work force with the rapid economical renaissance and introduced the industrial trainee system to solve this problem in 1950`s. However, with the principle of circulated introduction of foreign workers in 1964, this system had no meaning of great importance anymore. In 1970`s, being abolished this system because of the increased cost for introducing new work forces, foreign workers could hold the permanent residentship legally possible for inviting their family members who lived their mother countries. Despite an action suspending the recruitment for unskilled foreign work force was operated in 1973, since then, the permanent residence system had been criticized. Through a series of policies for introducing the foreign workers, Germany became an immigrant country. Korea enacted the Act for Employment Foreign Workforce and operated the employment permit system in August 2004. However, this policy has many problems such as legal loopholes, lack of rationality of the act and mass-production of illegal sojourners. Therefore, this paper comparatively examines German statutes relating to the foreign workers and our employment permit system and seeks legal and political problems of our systems. And then, it suggests some practical ways to reform these problems.
DB 보안의 문제점 개선을 위한 보안등급별 Masking 연구
백종일(Jong-Il Baek),박대우(Dea-Woo Park) 한국컴퓨터정보학회 2009 韓國컴퓨터情報學會論文誌 Vol.14 No.4
오라클 DBMS의 8i버전에서는 암호화 모듈이 기본적으로 장착되어 있으나, 암호화 모듈은 성능저하가 야기되어 제한적으로 적용되고 있다. 본 논문에서는 인덱스검색, 객체관리 혼란, 암호화로 인한 심각한 DB성능 저하, 실시간 데이터 암호화 미지원 IP기반의 데이터 접근제어 미지원으로 인한 기술별로 DB 보안의 문제점을 분석한다. 그리고 DB 보안의 가용성을 향상시키기 위해 암호화기술의 대체수단인 DB Masking 기법을 활용한 종합적인 보안 프레임워크를 제안한다. 취약점 개선안으로 가상계정을 이용하여 보안등급별로 DB Masking 기준을 설정하고, 가상계정을 통한 사용자 인증과 SQL문의 사전, 사후 결재 및 무결성을 체크하고, 감사 로그로 수집하여 DB를 안전하게 관리 할 수 있는 방안으로 활용한다. An encryption module is equipped basically at 8i version ideal of Oracle DBMS, encryption module, but a performance decrease is caused, and users are restrictive. We analyze problem of DB security by technology by circles at this paper whether or not there is an index search, object management disorder, a serious DB performance decrease by encryption, real-time data encryption beauty whether or not there is data approach control beauty circular-based IP. And presentation does the comprehensive security Frame Work which utilized the DB Masking technique that is an alternative means technical encryption in order to improve availability of DB security. We use a virtual account, and set up a DB Masking basis by security grades as alternatives, we check advance user authentication and SQL inquiry approvals and integrity after the fact through virtual accounts, utilize to method as collect by an auditing log that an officer was able to do safely DB.