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배은희,이종운,마성권,김수완 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites and positive sodium balance. The plasma and urinary ANP (atrial natriuretic peptide) immunoreactivities were increased. ANP mRNA expression was increased in the heart and kidney, whereas that of NPR (natriuretic peptide receptor)-A and NPR-C mRNA was decreased in the kidney. The expression of NEP was decreased in the kidney. At day 14, urinary excretion of sodium did not differ from the control. The plasma ANP level and heart ANP mRNA expression returned to their control values. The expression of ANP mRNA in the kidney was increased in association with increased urinary ANP immunoreactivities. The expression of NPR-A in the kidney became normal, whereas that of NPR-C kept decreased. The expression of NEP (neutral endopeptidase) remained decreased. These findings suggest that the increased renal ANP synthesis in association with decreased metabolism via NEP and NPR-C may play a compensatory role against the development of sodium retention in nephrotic syndrome. The decreased of NPR-A expression in the kidney may contribute to the ANP resistance at day 7. The subsequent recovery of NPR-A expression may play a role in promoting sodium excretion in later stage (at day 14).
배은희,Bae, Eun-Hui 대한출판문화협회 1995 출판저널 Vol.175 No.-
방학을 맞아 서저머가에는 각 출판사들의 굵직한 기획물들이 경쟁적으로 선보이고 있다. 해외의 명작을 완역한 전집에서부터 그림채, 교육적 효과가 높은 기획물까지 다양해 어린이와 부모들의 발길을 끌어당기고 있다.
Water and Sodium Regulation in Heart Failure
배은희,마성권 전해질고혈압연구회 2009 Electrolytes & Blood Pressure Vol.7 No.2
Heart failure is the pathophysiological state characterized by ventricular dysfunction and associated clinical symptoms. Decreased cardiac output or peripheral vascular resistance lead to arterial underfilling. That is an important signal which triggers multiple neurohormonal systems to maintain adequate arterial pressure and peripheral perfusion of the vital organs. The kidney is the principal organ affected when cardiac output declines. Alterations of hemodynamics and neurohormonal systems in heart failure result in renal sodium and water retention. Activation of sympathetic nervous system, renin-angiotensin-aldosterone system and non-osmotic vasopressin release stimulate the renal tubular reabsorption of sodium and water. Dysregulation of aquaporin-2 and sodium transporters also play an important role in the pathogenesis of renal sodium and water retention.
배은희,Bae, Eun-Hui 대한출판문화협회 1993 출판저널 Vol.134 No.-
먹거리에서 영양소로, 다시 문화현상으로 변화된 음식. 건강에 대한 지대한 관심을 반영한 바른 식품선택을 돕는 책과, 음식문화를 문화사적인 관점에서 조명한 '음식문화사'들의 출판이 최근 열기를 띠고 있어 출판계의 비상한 관심을 모으고 있다.