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흰쥐에 있어서 Symphytum officinale L . 추출액의 독성에 관한 연구
방형애,이용욱 한국식품위생안전성학회 1997 한국식품위생안전성학회지 Vol.12 No.2
This study was performed to investigate the toxic effect of pyrrolizidine alkaloids from Symphytum officinale in rat. For this experiment, 120 male and female rats of Sprague-Dawley strain were used. The experimental groups were divided into five: Group CM and CF served as normal control with its gender. Group EMl and EF1 were fed a 1% Symphytum officinal extract diet for 8 weeks. Group EM2 and EF2 fed a diet containing 2% extract diet. 4% extract diet into group EM3 and EF3 and 8% extract diet into group EM4 and EF4 were given. The results were as follows: 1. The major alkaloids of Symphytum officinale extract were symphytine, echimidine, and lasiocarpine. The amounts of total alkaloid were 168 ug PAs/ ml extract. And contents of PAs in leaves were 0.05% wt.. 2. Total serum bilirubin concentrations increased significantly in group EM2, EM3, and EM4. Group EFl, EF2, EF3,and EF 4 showed statistical significance for the group CF (p$lt;0.05). 3. Aspartate transaminase activities were increased significantly in group EM3 and EM4 (p$lt;0.05). Aspartate transaminase activities of EF1, EF2, EF3, and EF4 showed statistical significance for the group CF (p$lt;0.05). 4. Alanine transaminase activities increased significantly in group EM3, EM4 (p$lt;0.05). Alanine transaminase activities of EFl, EF2, EF3, and EF4 showed statistical significance for the group CF (p$lt;0.05). 5. Alkaline phosphatase activities increased significantly in group EM2, EM3, and EM4 (p$lt;0.05). Alkaline phosphatase activities of EF1, EF2, EF3, and EF4 showed statistical significance for the group CF (p$lt;0.05). 6. Histopathological analysis of liver specimens from group EM3 and EM4 showed focal necrosis, periportal necrosis and apoptosis. Hepatocytes obtained from group EM2 showed fatty change and hydropic degeneration in group EM3 and EM4. Chromatolysis and chromatin margination was shown in group EF2 and EF3. With the above results, it was demonstrated that the Symphytum officinale extract could induce functional change of liver, and histopathological change of liver in rats fed a diet containing extract. In conclusion, because of the risk of intoxication or adverse effect, the composition, dosage and mode of administration of herbal products should be monitored strictly. And this study serves as a reminder that herbal as well as orthodox medications may have serious side effects.
先天性 代謝障碍疾患의 治療를 위한 食餌療法에 關한 考察
方炯愛 서울大學校保健大學院 1992 國民保健硏究所硏究論叢 Vol.2 No.2
Recent advances in treatment of inherited metabolic disorders include diet therapy, organ transplantation, enzyme supplement and gene therapy. Diet therapy is a helpful treatment and alternative or complementary to drugs, especially in amino acid abnormality and galactosaemia. With early diagnosis and early treatment with therapeutic diets, the symtoms and signs of the these disease may be prevented or reversed. Phenylketonuria(PKU) is one of the better known examples of an inborn error of amino acid metabolism. Diet therapy for PKU consists of a combination of low protein foods and a phenylalanine free mixture of other essential amino acid. And the amounts of these two are adjusted to maintain plasma phenylaianine neither too high (toxicity) nor too low (inadequate growth). Galactosaemia may be arrested by eliminating milk and its product from diet. Recent evidence, however, has indicated that despite early diagnosis and the institution of a galactose free diet there appears to be an inability to prevent some degree of mental retardation and complicate long term outcome.