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수용액 중 Trimebutine maleate의 안정성
박종현(Jong Hyen Park),이계주(Gye Ju Rhee) 大韓藥學會 1990 약학회지 Vol.34 No.6
The effects of temperature, pH, light and concentration on the degradation of trimebutine maleate in aqueous solution were investigated on the basis of accelerated stability analysis, and the stabilization of the solution was attempted by addition of several additives. The decomposition of trimebutine maleate in solution followed first-order reaction the was not only accelerated by temperature elevation but also the lower the concentration the more speeded up the reaction. The decomposition mechanism of trimebutine could be confirmed by hydrolysis of ester bond in the structure. It was assumed trimebutine maleate is so photosensitive that the solution of the drug underwent accelerated decomposition under UV rays. What is more, the degradation of trimebutine solution was supposed to catalyzed by specific acid-base catalysis considered the pH dependence for the hydrolysis of ester, and the solution was most stable over the range of pH 2-2.8 in solution. The additives, citric acid, aspartic acid and glutamic acid, inhibited considerably the decomposition of the drug solution, and these additives might be used as stabilizers in trimebutine maleate solution.
Labeling 방식에 따른 XML 데이터의 갱신 성능 분석
정민옥(Min-Ok Jung),남동선(Dong-Sun Nam),한정엽(Jung-Yeob Han),박종현(Jong-Hyen Park),강지훈(Ji-Hoon Kang) 한국정보과학회 2005 한국정보과학회 학술발표논문집 Vol.32 No.1
XML is situating a standard for data exchange in the Web. Most applications use database to manage XML documents of high-capacity efficiently. Therefore, most applications create label that expresses structure information of XML data and stores with information of XML document. A number of labeling schemes have been designed to label the element nodes such that the relationships between nodes can be easily determined by comparing their labels. With the increased popularity of XML data on the web, finding a labeling scheme that is able to support order-sensitive queries in the presence of dynamic updates becomes urgent. XML documents that most applications use have many properties as their application. So, in the thesis, we present the most efficient updating methods dependent on properties of XML documents in practical application by choosing a representative labeling method and applying these properties. The result of our test is based on XML data management system, so it expect not only used directly in practical application, but a standard to select the most proper methods for environment of application to develop a new exclusive XML database or use XML.
수용액 중 Trimebutine maleate의 안정성
박종현,이계주 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-
The effects of temperature. pH. light and concentration on the degradation of trimebutine maleate in aqueous solution were investigated on the basis of accelerated stability analysis, and the stabilization of the solution was attempted by addition of several additives. The decomposition of trimebutine maleate in solution followed first-order reaction the was not only accelerated by temperature elevation but also the lower the concentratin the more speeded up the reaction. The decomposition mechanism of trimebtine could be confirmed by hydrolysis of ester bond in the structure. It was assumed trimebutine maleate is so photosensitive that the solution of the drug underwent accelerated decomposition under UV rays. What is more, the degradation of trimebutine solution was supposed to catalyzed by specific acid-base catalysis considered the pH dependence for the hydrolysis of ester, and the solution was most stable over the range of pH 2-2.8 in solution. The additives, citric acid, asparitc acid and glutamic acid, inhibited considerably the decomposition of the drug solution, and these additives might be used as stabilizers in trimebutine maleate solution.