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김희준,Kim, Hui-Jun 한국과학기술단체총연합회 1999 과학과 기술 Vol.32 No.4
20세기의 화학은 크게 발전한 고분자화학 덕분에 인공섬유와 인공수지를 탄생시켰으며 폐결핵을 몰아낸 설파계 약품을 개발했다. 그러면 다가오는 21세기의 화학은 어떠한 화합물을 만드는데 주력할 것인가? 가장 기대되는 화학의 새로운 분야는 나노구조의 화학과 생명공학 관련 화학이 될 것이다.
김희준,Kim, Hui-Jun 한국과학기술단체총연합회 1999 과학과 기술 Vol.32 No.3
인류문명의 발달사를 보통 석기, 청동기, 철기시대로 구분하는데 그렇다면 앞으로 다가올 21세기 이후는 어떤 시대가 될 것인가. 주기율표를 따져보면 불을 일으킨 부싯돌이나 돌도끼의 주성분이 실리콘(규석)이기 때문에 석기시대를 실리콘시대로 볼 수 있으며 청동기를 거쳐 철기시대인 현대엔 다시 실리콘시대로 돌아와 탄소에서 일단 대단원의 막을 내리게 될 것으로 본다. 탄소는 21세기에도 과학기술의 핵심 원소로 중요한 역할을 담당할 것이다.
김희준,Kim, Hui-Jun 한국과학기술단체총연합회 1999 과학과 기술 Vol.32 No.2
화학은 처음 중성원자로서의 수소가 생겨난 이후 옥텟규칙에 따라 최초의 분자인 수소분자가 우주공간에서 만들어지면서 분자과학으로서의 막을 올리게 된 것이다. 지금까지 화학은 원자들을 꿰어서 약 1천8백만가지의 화합물질을 만들어 냈다. 화학자들은 또 자연에 의존하는 화합물중에서 유용한 것을 골라내기도 하지만 전혀 새롭고 유용한 화합물을 설계하고 만들어왔는데 이처럼 다양하고 신비로운 화학의 세계를 들여다 본다.
녹용 약침과 산조인 약침이 정상인의 심박변이도(HRV)에 미치는 영향
김희준,송범용,육태한,Kim, Hui-Jun,Song, Beom-Yong,Yook, Tae-Han 대한약침학회 2009 Journal of pharmacopuncture Vol.12 No.3
Objective : This study was to investigate the effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture have on the autonomic nervous system. Methods : 60 healthy male volunteers were divided into three groups which consist of two experimental groups such as Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture, and a control group. Study design was a randomized, placebo-controlled, double-blind clinical trial. 20 subjects in experimental group were injected distilled Cervi Pantotrichum Cornu Pharmacopuncture at $GB_{21}$(Kyonjong), 20 subjects in other experimental group were injected distilled Zizyphi Spinosi Semen Pharmacopuncture and 20 subjects in control group were injected Normal Saline at $GB_{21}$(Kyonjong). One volunteer of each groups were excluded from analysis because of error during measuring HRV. At the end of the study 57 volunteers completed HRV analysis. HRV was measured by QECG-3:LXC3203(LAXTHA Inc. Korea) at P0, P1, P2, P3, P4, P5 and P6 and its time-course dependent change in each group was analyzed using paired t-test, and the difference of HRV fluctuation among two experimental group and a control was evaluated by one way ANOVA(p<0.05). Results : A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased only at 20 minutes after injection. SDNN was significantly increased from 15 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Complexity was significantly decreased at 10, 15 and 30 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, pNN50 was significantly decreased at 15, 20 and 25 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture showed significant difference on HRV index and pNN50 at 5 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(VLF) After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at 15 and 30 minutes after injection. Ln(VLF) was significantly increased at 10, 15 and 30 minutes after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Ln(VLF) was significantly increased only at 30 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture showed significant difference on Ln(TP) after 5 minutes of injection. Conclusions : Our results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.