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家兎側腦室內에 注入한 Adrenoceptor 遮斷劑의 末梢血液에의 流出에 關하여
金泰堯 전북대학교 의과학연구소 1982 全北醫大論文集 Vol.6 No.1
It was attempted in this investigation to find out whether or not several alpha- and beta- adrenoceptor antagonists injected intraventricularly leak and reach to the systemic circulation in anesthetised rabbits. 1. When given intraventricularly(i.vt.) alpha-adrenoceptor antagonists, yohimbine and piperoxan, produced pressor effect but when given intravenously(i.v.) they elicited transient depressor reponse. 2. I.vt. yohimbine, phenoxybenzamine and phentolamine did not affect the pressor effect of I.v. norepinephrine(NE) but their I.v. administration inhibited the effect of NE. Prazosin and thymoxamine, given either by I. vt. or I. v., inhibited the effect of NE. 3. When given I.vt. beta-adrenoceptor antagonists, practolol and sotalol did not affect the cardioaccelerator and depressor effects of I.v. isoproterenol(ISP) but when given I.v. practolol inhibited the cardioaccelerator effect and sotalol attenuated the depressor effect of ISP respectivel. dl-Propranolol and pindolol, given either by I.vt. or I.v., inhibited both effects of ISP. 4. Both I.vt. and I.v. d-propranolol did not affect the both effects of ISP. 5. These results indicate that I.ve. prazosin, thymoxamine, dl-propranolol and pindolol leaked into the systemic circulation.
김태요,이철,Ji-Na Kim 대한마취통증의학회 2012 Anesthesia and pain medicine Vol.7 No.2
Arnold-Chiari malformation type I (ACM I) is anatomically defined as the displacement of the cerebellar tonsils below the level of the foramen magnum. Syringomyelia is a condition in which a cavity called a syrinx develops in the spinal cord and is filled with cerebrospinal fluid. Here we report the anesthetic management of a case of ACM I with associated syringomyelia scheduled for suboccipital craniectomy, cervical laminectomy and duraplasty.
완전 좌각 블록크 (Complete LBBB) 환자의 마취관리
김태요,송윤강 圓光大學校 醫科學硏究所 1985 圓光醫科學 Vol.1 No.1
A 67 year-old female patient of shock state was scheduled for exploratory laparatomy under impression of peritonitis due to perforated viscus. The preoperative electrocardiography showed complete left bundle branch block ( CLBBB ) without any subjective symptoms. We performed balanced anesthesia with N_2O-O_2, muscle relaxant and 1P PV supplemented by morphine. The anesthetic management during pre-, intra- and postoperative period was satisfactory.
Oxymetazoline 의 家兎 心博 減少作用에 관한 硏究
金泰堯 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.2
1. Oxymetazoline, which has been shown to act preferentially on α_2-adernoceptors in some peripheral tissues and to act on α_1-adrenoceptors of the vascular smooth muscle and brain of the rabbit to induce a hypertensive effect, produced a bradycardiac effect in rabbits with the blockade of muscarinic receptors of the auricle by methylscopolamine pretreatment. It was attempted in this study to clarify the mechanism of this bradycardia. 2. The bradycardiac effect produced by either intravenous or intraventricular administration persisted until after the hypertension subsided. 3. The bradycardia of i.v. oxyrnetazoline was markedly inhibited by the treatment of rabbits with either guanethidine, chlorisondamine or propranolol. It was hardly seen in reserpine-pretreated rabbits and cord-sectioned ones. 4. Both the hypertension and bradycardia of i.v. oxymetazoline were inhibited by i.v. prazosin. 5. Yohimbine (i.v.) did not affect the hypertension of i.v. oxyrnetazoline, but weakened the bradycardiac effect, although not significant. 6. The hypertensive effect of i. vt. oxyrnetazoline was reduced by i. vt. prazosin, but the bradycardia was not affected. 7. Yohimbine (i.vt.) did not affect the hypertension of i.vt. oxyrnetazoline, but markedly reduced the bradycardiac effect. 8. The bradycardia of i.vt. oxymetazoline was not seen in reserpine-pretreated rabbits and rabbits treated with both guanethidine and chlorisonda-mine. 9. It is inferred that oxymetazoline induces the bradycardiac effect by acting on the α_2-adrenoceptors in the rabbit-heart and brain.
김태요,정용관,전철용,이철,손윤강,최덕화 대한마취통증의학회 2004 Korean Journal of Anesthesiology Vol.47 No.3
We experienced a malignant hyperthermia in 24-year-old male with sevoflurane during the mandibular prognathism surgery. The malignant hyperthermia emerged 150 minutes after induction of general anesthesia using propofol, rocuronium, sevoflurane, N2O and O2. Sevoflurane has been reported that it can induce delayed onset of malignant hyperthermia under absence of succinylcholine. The prognosis of malignant hyperthermia is determined by early recognition, vigorous treatment and the time of dantrolene injection. In our case, when we suspected episode, all anesthetics were stopped and dantrolene injection was immediately given intravenously. The patient recovered normal temperature and consciousness without any complication. (Korean J Anesthesiol 2004; 47: 449~53) 악성 고열증은 전신 마취 중에 관찰되는 임상 증후군으로 5분에 1oC 정도로 빠르게 체온이 상승하고 골격 근육의 심한 횡문근 융해(rhabdomyolysis)를 초래하는 골격근 내의 급격한 대사 증가가 원인으로 사망률이 매우 높은 질환이다.1) 악성 고열증의 유발 인자로는 모든 종류의 휘발성 흡입 마취제와 탈분극성 근이완제, stress, caffeine, chloropromazine 등이 있다. 1960년 Denborough와 Lovell에 의해 처음 보고 된 후 70% 이상이었던 사망률은 최근 더 빠른 진단과 dantrolene의 사용에 의해 5% 이하로 감소되었다. 저자들은 sevoflurane 마취 하에 구강외과 수술 중 발생한 악성 고열증을 경험하였고 특별한 합병증 없이 회복되었기에 문헌 고찰과 함께 보고하는 바이다.