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김창덕(Chang Duk Kim),류영욱(Young Wook Ryoo),이규석(Kyu Suk Lee) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.12
Focal dermal hypoplasia or Goltz syndrome is a rare genetic mesodermal and ectodermal disorder characterized by variable multisystem defects, including anomalies of the skin, skeleton, teeth and eyes. The disorder appears to be lethal in males and there is a large dominance of female cases; hence, X-linked dominant inheritance has been postulated. A 10-year-old female patient presented with soft extruding nodules on the hyperpigmented patch on the right leg, reticulated hyperpigmentd patches and plaques scattered over the trunk and extremities, and focal alopecia on the scalp. In addion to the skin lesions, this patient showed syndactyly of the right 2nd, 3rd fingers and 4th, 5th fingers, developmental anomaly of the right foot including syndactyly and hypoplasia of the toes, hemiatrophy of the right side of the face, and irregular spacing of teeth and malocclusion. Histopathological findings of soft pinkish nodule on the right leg revealed very thin layered collagen fibers on the dermis and presence of adipose tissue very near to the epidermis that largely replaced the upper dermis. (Korean J Dermatol 2001;39(12):1411~1414)
R407C를 적용한 슬릿휜-관 열교환기의 증발특성에 관한 연구
김창덕(Chang-Duk Kim),장경근(Kyoung-Keun Jang),남임우(Leem-Woo Nam),전창덕(Chang-Duk Jeon),이진호(Jinho Lee) 대한기계학회 2001 대한기계학회 춘추학술대회 Vol.2001 No.9
This paper presents the evaporation characteristics of slit fin-tube heat exchanger installed into air-conditioning machines, due to the use of the alternative refrigerant. The experiments were conducted in order to investigate the effects of the temperature glide and the length of two phase region for ternary non-azeotropic refrigerant mixture R407C, which is one of the potential candidates for pure refrigerant R22. Test were conducted in a closed loop wind tunnel. The evaporation temperature of the refrigerant at the test section inlet were maintained at 7℃. The data covers a range of refrigerant mass fluxes 150-250 ㎏/㎡s supplied with air flows at velocities in the range 0.6-1.6 ㎧.
평활근 증식과 점액성 기질 변화를 보인 사구맥관근종 1 예
김창덕(Chang Duk Kim),박재홍(Jae Hong Park),류영욱(Young Wook Ryoo),김병천(Byung Chun Kim),이규석(Kyu Suk Lee) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.10
Glomus tumors are benign neoplasms that are derived from modified smooth muscle cells known as glomus cells. Histologically, it can be subdivided as glomus tumor proper, glomangioma, and glomangiomyoma according to relative proportions of components. Glomangiomyomas are the least frequent type and their overall architectural pattern may resemble glomus tumor proper or glomangioma, but there is a gradual transition from glomus cells to elongated mature smooth muscle cells. This transition is most obvious in the region surrounding large vessels. We present a case of glomangiomyoma of the left upper arm and the left fourth finger, in which ten-year history of two painful, bluish-colored subcutaneous nodules. On histologic examination, this case showed marked smooth muscle cell proliferation around large vessles and mucinous stromal change. (Korean J Dermatol 2001;39(10) 1147-1151)
Dehydroepiandrosterone 에 의한 탄력소 유전자의 발현 조절
김창덕(Chang Duk Kim),이규석(Kyu Suk Lee),류영욱(Young Wook Ryoo) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.6
N/A Background : Dehydroepiandrosterone(DHEA) and its sulfate ester dehydro- epiandrosterone sulfate(DHEA-S) are the steroids secreted most abdundantly by the human adrenal gland, but the physiologic role remains uncertain . Elastin is one of the major extracellular matrix components of ant the dermis and plays an important role in providing elasticity and resilience of the skin. Expression of elastin gums at transcriptional level is regulated and modulated by cytokines, vitamin D3, insulin-like growth factor-1, and steroids But only little is known about the molecular and cellular mechanism underlying the effect of DHEA on the expression of elastin in cultured skin fibroblasts. Objective : The purpose of this study was to examine the effect of DHEA on elastin gene expression in cultured skin fibroblasts. Methods : In this study, the effects of DHEA were examined by Northern blot hybridization, chloramphenicol acetyltranferase assay (CAT). and laser scanning microscopy in cultured human fibroblasts. Results : In Northern blot hybridization, levels of elastin mRNA we, increased 1.5-fold at 1 nmol of DHEA, 4.2-fold at 0.1 μ㏖ and 6.5-fold at 10 μ㏖, compared to untreated control. DHEA caused a alteration in the elastin mRNA expression in a dose-related fashion. In CAT assay, the relative mRNA CAT activity was 0.9 at a concentration of 1 nmol 2.4 at 0.1 μmol, and 2.7 at a 10 μ㏖. DHEA caused a marked increase on elastin promotor activity. In confocal laser scanning microscopy. the immunosignal for elastin in DHEA-treated fibroblasts is more intense compared to the control. Conclusion : These results indicate that DHEA may be a powerful up-regulator of elastin production, suggesting transcriptional activation of gene expression in cultured skin fibroblasts.
김창덕 ( Chang Duk Kim ),김창욱 ( Chang Ook Kim ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7
N/A Background : Many studies focused on the distribution of skin tumors in Korea, but none of them included whole data refered from deparments other than dermatology and primary physicians. Objective : This study was to investigate the incidence and distribution of skin tumors among Korean people. Methods : A study was made on 1448 cases of skin tumors which were obtained mainly from surgical pathology specimen during the period of 10 years from 1992 to 2001 at Department of Dermatology in Keimyung University Dongsan Medical center. Results : 1. Of the 1448 cases of skin tumors, 1171 cases(80.9%) were benign tumor, 277 cases (19.1%) were malignant tumor and male to female ratio was 1:1.1. 2. Among the 1171 cases of benign tumors, 174 cases of melanocytic nevi, 173 cases of epidermal cyst, 109 cases of seborrheic keratosis, 62 cases of granuloma pyogenicum were noted. 3. Among 277 cases of malignant tumors, 107 cases of basal cell carcinoma, 58 cases of squamous cell carcinoma, 27 cases of metastatic cutaneous carcinoma, 24 cases of Bowen disease were noted. 4. The predilection sites of Intradermal nevi were face(38.4%), trunk(17.4%), scalp(16.3%), and those of epidermal cyst were face(41.0%), trunk(29.5%), neck(8.1%), The predilection site of basal cell carcinoma, squamous cell carcinoma was face(80.4%, 58.6%). Conclusion : The 1448 cases of skin tumors, which were confirmed histologically from surgical pathology specimen at Department of Dermatology in the Keimyung University Dongsan Medical Center during the period of 10 years from 1992 to 2001, were reviewed.