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      • KCI등재후보

        당뇨병 환자에서 RR 간격의 변화에 관한 연구

        김완중(Wan Jung Kim),김중남(Jung Nam Kim),김호중(Ho Jung Kim),문철웅(Chul Oong Moon),이승일(Soung Il Lee),장경식(Kyoung Sig Chang),홍순표(Soon Pyo Hong) 대한내과학회 1990 대한내과학회지 Vol.39 No.4

        N/A Heart rate variability is a noninvasive index of the neural, especially parasympathetic, activity of the heart. Autonomic neuropathy is frequently observed in diabetic patients, and a 5-year survival rate of this kind of patient is low. To evaluate autonomic neuropathy in diabetic patients, 35 diabetic patients (proliferative retinopathy: 14, neurogenic bladder:8, postural hypotenion:6) measured for RR intervals and Valsalva ratios compared with 77 persons of the normal control group. RR variations (standard deviation: SD, coefficient of variation: CV, max-min, max/min) during deep respiration and Valsalva ratios (Vmax-Vmin, Vmax/Vmin) during Valsalva maneuver were significantly lower in the diabetic patients than in the normal control group (p<0.001, respectively). RR variations and Valsalva ratios decreased progressively with an increase of age in the control group and in diabetic patients (p<0.001, respectively). RR variations and Valsalva ratios were significantly lower in the diabetic patients with retinopathy, neurogenic bladder, and postural hypotension compared to diabetic patients without such conditions (P value <0.01, <0.05, <0.05, respectively). It is concluded that diabetic autonomic neuropathy can be indicated by the measurement of RR variations and Valsalva ratios.

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        소화성 궤양환자의 흡연여부에 따른 혈청 Pepsinogen 1 치의 변화

        오재선(Jae Sun Oh),김평남(Pyung Nam Kim),나한식(Han Sik Na),김중남(Jung Nam Kim),문철웅(Chul Oong Moon),김만우(Man Woo Kim),양성훈(Sung Hun Yang) 대한내과학회 1990 대한내과학회지 Vol.39 No.4

        N/A Serum group I Pepsinogen (sPG I) levels were measured by radioimmunoassay in 159 patients undergoing endoscopy, then all patients were classified by endoscopic diagnosis, gastric mucosal histology, and smoking habits. The results were as follows: 1) Both nonulcer dyspepsia and duodenal ulcer smokers had significantly higher sPG I levels than their nonsmoking controls (p<0.005). 2) The frequency distvibution of superficial gastritis in the nonulcer dyspcpsia group with smoking habits revealed significantly higher levels than that of the nonsmoking controls (p<0.0025). 3) Serum PG Iin nonulcer dyspepsia patients revealed significantly higher levels in patients with superficial gastritis but there were not related to cigarette smoking. 4) The relationship between the mean level of serum PG I and fundic mucosal histology in duodenal ulcer patients was found to be statistically insignificant, but the mean level of sPG I in the smoking group showed a higher value than that of the nonsmoking controis (p< 0. 05). 5) The frequency distribution of high serum PG I level (> 80 ng/ml) in duodenal ulcer smokers was higher than that of the nonsmoking control group (chi square test: p<0.). From the above findings, it is concluded that the smoking induced increase in sPG I in duodenal ulcer is proposed to release an augmented pepsin secretory capacity, which can have aetiologic significance in association between smoking and duodenal ulcer.

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