Moutan Cortex Extract Inhibits Amyloid ${\beta}$ Protein (25-35)-induced Neurotoxicity in Cultured Rat Cortical Neurons

김주연,주현수,반주연,송경식,성연희,Kim, Joo-Youn,Ju, Hyun-Soo,Ban, Ju-Yeon,Song, Kyung-Sik,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2008 한국약용작물학회지 Vol.16 No.6

Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), has pharmacological effects such as anti-inflammatory, antiallergic, analgesic and antioxidant activities. We investigated a methanol extract of Moutan cortex for neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to $10\;{\mu}M\;A{\beta}$ (25-35) for 24 h induced neuronal apoptotic death. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced neuronal cell death at 30 and $50\;{\mu}g/m{\ell}$, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) which were measured by fluorescent dyes. Moutan cortex also inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$ (25-35), which was measured by HPLC. These results suggest that Moutan cortex prevents $A{\beta}$ (25-35)-induced neuronal cell damage by interfering with the increase of $[Ca^{2+}]_i$, and then inhibiting glutamate release and ROS generation. Moutan cortex may have a therapeutic role in preventing the progression of Alzheimer's disease.

빛의 유입에 의한 공간특성에 관한 연구 : 루이스 칸을 중심으로

김주연 ( Joo Yun Kim ),김지현 ( Ji Hyun Kim ) 한국기초조형학회 2007 기초조형학연구 Vol.8 No.4

난소 갑상선종에서 기원한 유두상 갑상선암종 증례 보고 및 문헌 고찰

김주연 ( Joo Yuen Kim ),임유진 ( You Jin Lim ),이종심 ( Jong Sim Lee ),이선주 ( Sun Joo Lee ),박정열 ( Jeong Yeol Park ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9

About 15-20% of ovarian tumors are teratomas. Struma ovarii is a highly specialized form of ovarian teratoma, in which thyroid tissue is the predominant element. It is rare, comprising about 2% of all teratomas, and malignant transformation occurs in less than 5% of struma ovarii. Among the malignant struma ovarii, papillary type is the most common histologic type. However, because of the rarity of malignant struma ovarii, there is considerable confusion concerning management. Recently, the authors experienced a case of papillary thyroid carcinoma arising in struma ovarii found in a postmenopausal woman who presented with adnexal mass and underwent laparoscopic unilateral salpingoophorectomy. Therefore, we report this rare case with a brief review of the literature.

한국의 무예 단체현황

나영일 ( Young Il Na ),노영구 ( Young Goo Noh ),김주연 ( Joo Youn Kim ),김은정 ( Eun Jung Kim ),오현택 ( Hyun Taek Oh ),천호준 ( Ho Jun Cheon ),김기탁 ( Ki Tak Kim ),조양수 ( Yang Soo Cho ),김대환 ( Dae Hwan Kim ),김식 ( Sik Kim 대한무도학회 2004 대한무도학회지 Vol.6 No.2

다크투어리즘 방문동기가 진정성, 감정, 만족 및 태도변화에 미치는 영향: 서대문형무소역사관을 중심으로

김주연(Ju-Yeon Kim),최현주(Hyun-Joo Choi) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.3

본 연구는 역사를 소재로 한 다크투어리즘 방문객들의 방문동기를 도출한 후, 방문목적지에서 경험한 진정성과 감정, 만족, 태도변화 간의 영향관계를 파악하고, 이를 기반으로 방문 후 역사에 대해 어떠한 태도변화를 일으키는지를 파악하고자 하였다. 이를 위해 국내 대표적인 다크투어리즘 장소 중의 하나인 서대문형무소역사관을 방문한 경험이 있는 15세 이상을 대상으로 2020년 8월 3일~20일 동안 온라인조사를 통해 수집된 347부를 최종 활용하였다. 분석결과, 다크투어리즘 방문동기(탐구성, 역사성, 일탈과 자아성찰) 중 탐구성과 역사성은 진정성과 감정에 모두 유의한 영향을 미치며, 만족은 태도변화에 영향을 미치는 것으로 분석되었다. 또한, 진정성과 감정은 태도변화에 유의한 영향력을 갖는 것으로 나타났다. 본 연구는 다크투어리즘 방문경험으로 인해 역사에 대한 태도변화가 나타났음을 실증적으로 규명하였다. 다크투어리즘 방문동기요인 중 역사성은 진정성과 감정을 통해 역사에 대한 태도변화에 유의한 영향을 미치는 것으로 나타난 만큼, 역사의 현장에서 이야기를 기반으로 한 체험프로그램 강화가 요구된다. The purposes of the study were two-folded: to identify visitors’ motivations for the history-based dark tourism and to test empirically the relationships among visitors’ motivations, authenticity, emotion, satisfaction and attitude change. The online survey was conducted, from August 3rd to 20th of 2020, on visitors over 15 years old with previous experience with dark tourism within last three years. 347 individuals responded to the online survey. The study results were as follows: first, among four dark tourism visiting motivation including, motivation to research, historicalness, deviation, and self-examination, first two variables motivation to research and historicalness showed positive effect on authenticity and emotion. Second, the study found that visitors satisfaction influenced positively towards attitude change. Finally, authenticity and emotion positively influenced attitude change. This study empirically suggests a change in attitude toward history due to the dark tour. Since historicality has been shown to have a significant influence on the attitude of history through authenticity and emotion, it is necessary to strengthen story-based experience programs at historical sites.

전시참가자의 환경의식에 따른 친환경행동 및 친환경 전시 참여의도의 차이

김주연(Kim, Ju-Yeon),안경모(Ahn, Kyung-Mo),최현주(Choi, Hyun-Joo) 한국관광레저학회 2012 관광레저연구 Vol.24 No.5

베이비붐 세대의 행복여행 조건과 의미

김주연(Kim, Ju-Yeon),김민화(Kim, Min-Hwa),최현주(Choi, Hyun-joo) 한국관광레저학회 2022 관광레저연구 Vol.34 No.1

혈액투석 환자의 음식갈망 영향요인

김주연 ( Kim Ju Yeun ),주현실 ( Joo Hyun Sil ) 병원간호사회 2017 임상간호연구 Vol.23 No.3

Purpose: The purpose of this study was to evaluate food carving among hemodialysis patients and to identify factors affecting the food carving. Methods: A descriptive correlational study was conducted. Data were collected from 129 patients receiving hemodialysis between March 15 and April 15, 2017. Measurement instruments included the general food craving questionnaire trait, the center for epidemiological studies-depression scale, and stress response inventory-modified form. The statistical analysis included t-test, analysis of variance, pearson correlation analysis, and stepwise multiple regression analysis. Results: Mean food craving score was 53.00±12.36. Food craving was higher in patients younger than 40 years (F=4.36 p=.006) and having occupation (t=2.18 p=.031). Patients receiving hemodialysis demonstrated higher levels of depression (21.37±9.62) and stress (39.68±15.95). Factors influencing food craving were depression (β=.52, p<.001), stress (β=.65, p<.001), and age 50~59 years old (β=-.28, p=.001) and 60~69 years old (β=-.19, p=.026), which accounted for 25.6% of total variance. Conclusion: Food craving among hemodialysis patients was influenced by patients’ depression, stress and age. Assessment and management of depression and stress needs to be incorporated as a nursing strategy for dietary management for hemodialysis patients.

여수세계박람회 서비스품질, 감정반응, 지각된 가치 및 만족 간 구조적 인과관계

김주연(Ju-Yeon Kim),최현주(Hyun-Joo Choi),안경모(Kyung-Mo Ahn) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.3

본 연구는 2012여수세계박람회의 서비스품질이 참관객의 긍정적 감정반응,지각된 가치 및 만족에 미치는 영향을 파악하였다. 우선, 여수세계박람회의 서비스품질 척도를 전시컨텐츠, 공연의 질, 인적서비스, 접근?편리성, 소요비용 5가지 차원으로 구성하였다. 각 구성개념간의 영향관계 분석결과, 전시컨텐츠, 공연의 질, 소요비용이 참관객의 긍정적 감정에 유의한 영향을 미쳤으며, 그 중 전시컨텐츠가 참관객이 느낀 긍정적 감정에 가장 높은 영향을 미친 것으로 나타났다. 지각된 가치에 있어서는 전시컨텐츠, 소용비용과 접근편리성이 유의한 영향을 나타냈으며, 그 중 박람회 관련 소용비용이 지각된 가치에 가장 높은 영향력을 가졌으며, 접근편리성,전시컨텐츠 순으로 파악되었다. 참관객이 박람회서비스에 대해 느낀 긍정적 감정과 지각된 가치는 모두 만족에 유의한 영향을 미치는 것으로 분석되었고, 이 중 참관객의 긍정적 감정이 지각된 가치보다 다소 높은 영향을 미치는 것으로 파악되었다. This research has analyzed the influence of Yeosu Expo’s service quality on emotion, perceived value and satisfaction. First of all, the Yeosu Expo’s service quality scale was composed with five types of levels : exhibition contents, quality of performance, human service, approach? convenience and necessary expense. As the result of influence analysis, exhibition contents, quality of performance and necessary expense had significant influence on attendee’s positive emotion. Exhibition contents, necessary expense and approach?convenience to approach showed significant influence in perceived value, and necessary expense related to the expo had the highest influence among the three values. Also, the attendee’s positive emotion and perceived value towards service from expo was analyzed to have satisfactorily significant influence.

국립한글박물관 외래관람객 방문행태간 연관성 및 차이 분석

김주연(Ju-Yeon Kim),최현주(Hyun-Joo Choi),안경모(Kyung-Mo Ahn),푸레브자브(Purevjav.B) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.6

본 연구는 국립한글박물관 외래관람객 중 방문비중이 높은 미국, 일본, 중국 세 국적별 외래관람객들을 대상으로 방문행태, 전시시설 및 서비스 개선사항, 전시콘텐츠 및 전시서비스품질에 대한 만족, 전반적인 전시관람 만족 및 행동의도 간의 연관성 분석을 통해 주요 국적별 외래관람객들의 방문활성화 방안을 모색해 보았다. 분석결과, 세 국적별 외래관람객들의 방문행태 간 차이를 보였으며, 전시시설 및 서비스 개선사항은 미국인과 일본인 관람객은 ‘외국어 안내체계’, 중국인 관람객은 ‘체험 프로그램’이 가장 개선되어야 할 사항으로 나타났다. 또한, 전시콘텐츠 및 전시서비스품질에 대한 만족도는 미국인 관람객의 만족도가 일본인 및 중국인 관람객의 만족수준 보다 높은 경향을 보여 국적별 차이를 보였다. 아울러 국립한글박물관 관람을 마친 후 전반적인 전시관람 만족 및 관람 후 행동의도 간의 차이에서는 미국인 관람객의 만족과 행동의도 수준이 일본인 및 중국인 관람객에 비해 다소 높은 경향을 나타냈다. 이러한 연구결과를 토대로 외래관람객들의 국립한글박물관에 유도하기 위한 컨텐츠 개발 등 방문활성화 방안을 제시하였다. This research was designed to seek and plan the foreign tourists visiting the National Hangeul Museum revitalization method; foreign tourists in this research refer to Japanese, Chinese and Americans tourists since they make up the big proportion of foreign tourists visiting the National Hangeul Museum. This research was aimed to seek the visiting revitalization method through correlation analysis among: foreign tourists’ visiting purpose, requested improvement on exhibition facility and service, satisfaction level on exhibited contents and service quality, overall satisfaction level on viewing exhibition and behavior intention. As the result of research, tourists visiting purpose from three countries showed a difference; American and Japanese tourists picked ‘guidance system in foreign language’ while Chinese tourists picked ‘experiment programs’ as the most requested improvement on exhibition facility and service. Also, Tourist’ satisfaction level on exhibited contents and service quality showed a difference among tourists from three countries; American tourists’ satisfaction level was shown higher than that of Japanese and Chinese tourists. In addition, American tourists’ overall satisfaction level on exhibition and behavior intention after viewing the exhibition in National Hangeul Museum tends to be higher than that of Japanese and Chinese tourists. Based on this research, visiting revitalization method to attract more foreign tourists to the National Hangeul Museum, such as contents development is suggested in the research.