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광간섭 단층영상기술과 이광자 현미경을 이용한 in-vivo에서의 피부 염증 반응 가시화
김범주(Bumju Kim),이승훈(Seong Hun Lee),김기현(Ki Hean Kim) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
Among the various immune responses of the body, the earliest is the inflammation response. Quantitative measurement of the inflammation response is important for the diagnosis of several diseases and evaluation of new drugs responses. In this study, we induced an acute inflammation response by topical application of LPS on the mouse ear and the resulting characteristics of acute inflammation response such as tissue swelling, blood vessel dilation, immune cell migration were imaged. To do so, we used noninvasive 3D imaging technologies: optical coherence tomography (OCT) and two-photon microscopy (TPM), label free. OCT displayed the increase in thickness of tissue and changes in blood vessel distribution due to the inflammation response. Meanwhile, TPM displayed molecular and cellular information such as immune cell infiltration. Taken together, OCT and TPM provided information about the inflammation response from this model.