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정상크기의 신장을 가진 말기신부전 환자에서 발견된 허탈성사구체병증(Collapsing Glomerulopathy)
이준엽 ( Lee Jun Yeob ),김무곤 ( Kim Mu Gon ),서영진 ( Seo Yeong Jin ),유길종 ( Yu Gil Jong ),윤현대 ( Yun Hyeon Dae ),이인희 ( Lee In Hui ),안기성 ( An Gi Seong ),김용진 ( Kim Yong Jin ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Collapsing glomerulopathy is recently described as the disease which causes rapidly progressive renal failure. Clinically, the disease starts with constitutional symptoms, and then nephrotic syndrome with marked proteinuria and hypertension follows. Eventually the disease rapidly progresses to the ESRD within several weeks to months. Its typical renal biopsy findings are extensive glomerular capillary collapse, visceral epithelial cell hypertrophy and hyperplasia, and variable degree of tubulointerstitial inflammation. Such findings closely resemble those of HIV associated nephropathy(HIVAN) except endothelial inclusion body in HIVAN. Here we present, for the first time in Korea, a 16 yrs-old female patient with ESRD in a normal sized kidney. Nephrotic syndrome and hypertension were also accompanied. Serologically, she had no evidence of HIV infection. Though her symptom duration was somewhat shorter than that previously reported, her renal biopsy findings were those of collapsing glomerulopathy as pre-viously described. Her renal function did not return to normal, and now she is on regular hemodialysis, waiting for renal transplantation.