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임권일,김광수,유경무 고신대학교(의대) 고신대학교 의과대학 학술지 1997 고신대학교 의과대학 학술지 Vol.12 No.1
-Abstract- Puffer fish poisoning is a disorder which clinically manifests perioral paresthesia, motor paralysis, nausea, vomiting and in advanced case, respiratory failure followed by ingestion of a tetrodotoxic puffer fish. The results were summarized as follows: 1) The age at onset were 33-60 year old (mean 48.6 ± 7.7 year old). The prevalence in male is higher. 2) The seasonal preponderance was autumn and winter (80%). 3) The period from ingestion of puffer fish to first symptom was within 1 hour (50%). 4) The perioral paresthesia was the most common first symptom. 5) The prognosis was good in most cases, and one case expired, due to respiratory failure.
김광수,임권일,유경무 고신대학교(의대) 고신대학교 의과대학 학술지 1996 고신대학교 의과대학 학술지 Vol.11 No.1
-Abstract- Kainic acid (KA), a powerful excitatory analogue, induces limbic motor seizures and damages the hippocampus and limbic regions in rats. This study was undertaken to observe the behavioral pattern induced by systemic administration of KA in rats. Twenty-three adult male Sprague-Dawley rats experienced convulsions by a single intraperitoneal injection of variable convulsive doses (20, 30 and 40mg/kg) of KA respectively. The behavioral patterns were monitored for 3 hours after administration of KA. Most of the rats exhibited limbic motor epileptic activity. Severe limbic convulsion and status epilepticus progressively increased with the increasing doses of KA, but the time sequence in the onset of behavioral stages induced by administration of variable doses of KA was not significantly different.
김광수,임권일,유경무 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2
측두엽간질의 모형인 Kainic acid(KA) 유발발작 동물모형에서 발작양상을 관찰하였다. Sprague-Dawley종 수컷 백서 23마리를 실험대상으로 하였다. 이들 중 7마리는 20mg/kg 용량의 KA를 일회 복강내에 주사하여 발작을 유발하였으며, 8마리는 30mg/kg 용량의 KA를 투여하였고, 나머지 8마리는 40mg/kg 용량의 KA를 투여하였다. 각 실험백서들은 KA를 주사하고 나서 3시간동안 행동 및 발작반응을 관찰하여 KA용량에 따른 행동반응, 단계별 이행빈도 및 단계별 시작시간 등을 서로 비교하였다. 대부분 백서에서 KA에 의한 변연운동발작을 관찰할 수 있었으며, KA의 용량이 높을 수록 전신성 간질 및 간질중첩증의 발생이 많았다. 그러나 KA용량에 따른 단계별시작시간은 서로 비슷하였다. 그러므로 측두엽간질의 동물모형을 위해서는 20mg/kg 용량의 KA가 적절하며, 전신성 간질 및 간질중첩증의 동물모형을 얻기 위해서는 이 보다 많은 용량의 KA가 필요할 것으로 생각되었다. Kainic acid(KA), a powerful excitatory analogue, induces limbic motor seizures and damages the hippocampus and limbic regions in rats. This study was undertaken to observe the behavioral pattern induced by systemic administration of KA in rats. Twenty-three adult male Sprague-Dawley rats experienced convulsions by a single intraperitoneal injection of variable convulsive doses(20, 30, and 40mg/Kg) of KA respectively. The behavioral patterns were monitored for 3 hours after administration of KA. Most of the rats exhibited limbic motor epileptic activity. Severe limbic convulsion and status epilepticus progressively increased with the increasing doses of KA, but the time sequence in the onset of behavioral stages induced by administration of variable doses of KA was not significantly different.
임권일,김광수,유경무 고신대학교 의학부 1997 高神大學校 醫學部 論文集 Vol.12 No.1-2
Puffer fish poisoning is a disorder which clinically manifests perioral paresthesia, motor paralysis, nausea, vomiting, and in advanced case, respiratory failure followed by ingestion of a tetrodotoxic puffer fish. The results were summarized as follows : 1) The age at onset were 33-60 year old (mean 48.6± 7.7 year old). The prevalence in male is higher. 2) The seasonal preponderance was autumn and winter (80%). 3) The period from ingestion of puffer fish to first symptom was within 1 hour (50%). 4) The perioral paresthsia was the most common first symptom. 5) The prognosis was good in most cases, and one case expired, due to respiratory failure.