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육미지황탕가갈근(六味地黃湯加葛根)이 난소적출(卵巢摘出)로 유발(誘發)된흰쥐의 골다공증(骨多孔症)에 미치는 영향
이정우 ( Myung Kum Han ),권영달 ( Jae Kyun Won ),송용선 ( Chong Woo Lee ),원재균 ( Cheol Han Kim ),김철한 ( Young Dal Kwon ),권영미 ( Yung Sun Song ),권영미 ( Young Mi Kwon ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4
Objectives :This study was performed to investigate the effects of Yukmijiwhang-tang (Liuweidihuang-tang) with Puerariae raidx(YMG) on the ovariectomized rat model of postmenopausal osteoporosis. Methods : We used 9 week aged Sprague-Dawley rat and divided into four group, sham operation group(Control, C), ovariectomized group(Negative Control, N.C), administrated YMG 1,250 mg/kg/day after ovariectomy group(T1), administrated YMG 2,500 mg/kg/day after ovariectomy group(T2). Then we observed changes in the body weight, body fat, serum metabolic products, bone density and so on. Results : 1. Body weight in negative control group showed significant increase in comparison with control group, but that in T1 and T2 group showed decrease in comparison with negative control group. 2. In the autopsy, negative control group showed uterus atrophy in comparison with control group. While T1 and T2 group showed decrease in uterus atrophy in comparison with negative control group. 3. In the total cholesterol, negative control group showed a significant increase in comparison with control group. While T1 and T2 group showed a significant decrease in comparison with negative control group. 4. In the body fat, negative control group showed a tendency to increase in comparison with control group. While T1 and T2 group showed a tendency to decrease in comparison with negative control group. 5. In bone density, normal control group showed a tendency to decrease bone density in comparison with control group. While T1 and T2 group showed a tendency to increase bone density in comparison with negative control group. Conclusions : YMG has shown to be capable of preventing and curing osteoporosis induced by ovariectomy osteoporosis rats
독활기생탕(獨活寄生湯) 및 중성어혈약침(中性瘀血藥鍼)이 좌골신경 압좌손상 백서의 통증과 신경 재생에 미치는 영향
이상규 ( Sang Gyu Lee ),원재균 ( Jae Kyun Won ),염승룡 ( Seung Ryong Yeom ),이수경 ( Su Kyung Lee ),송용선 ( Yung Sun Song ),권영달 ( Young Dal Kwon ) 한방재활의학과학회 2009 한방재활의학과학회지 Vol.19 No.3
Objectives: The purpose of this Study was to identify the effect of Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture on pain control and nerve regeneration after crush injury in rat sciatic nerve. Methods: Neuropathic pain was induced by crush-induced model of right sciatic nerve. Animal groups were divided as follows; Group 1: no treatment control group, Group 2: experimental group treated with Dokhwalgisaeng-tang(Duhuoqisheng-tang), Group 3: experimental group treated with Jungsongouhyul pharmacopuncture, and Group 4: experimental group treated with Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture. To evaluate pain intensity, each group was observed paw withdrawal threshold and immunoreactivity on the c-fos before and after respective treatments in five hours, first, third, and fifth day. To evaluate nerve regeneration, those were observed SFI(Sciatic Functional Index) and GAP-43(Growth Associated Protein 43) after each treatment in seventh and thirteenth day. Results: 1. Paw withdrawal threshold to the mechanical stimuli made the significant difference between group Ⅳ and the control group after five days of the experiment. 2. Paw withdrawal threshold to the thermal stimuli made the significant difference between group 1 and 3, 1 and 4, 2 and 4. 3. In immunohistochemical response of c-fos, as time passes, the immunoreactivity of all groups was decreased gradually. Especially, group 4 was observed the lowest after three days. 4. The differences of sciatic function indexes in each group were significantly between group 1 and 3, 1 and 4, 2 and 4 after 14 days, and between group 1 and 3, 1 and 4, 2 and 4, 2 and Ⅳ after 21 days. 5. In immunohistochemical response of GAP-43, all groups had higher GAP-43 immunoreactivity at the 14 days from post-injury and group 4 showed highest immunoreactivity. Conclusions: Based on above the results, it is proposed that Dokhwalgisaeng-tang(Duhuoqisheng-tang) and Jungsongouhyul pharmacopuncture may be helpful as a treatment in neuropathic pain and nerve regeneration in rat model.
악관절 교정과 한방치료를 병행한 특발성 척추측만증 치험 3례
이영준 ( Young Jun Lee ),박단서 ( Darn Seo Park ),원재균 ( Jae Kyun Won ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.3
Objectives:This study is designed to report the effectiveness of idiopathic scoliosis with treatment of temporomandibular joint disorder (TMJD).Methods:The therapies were Functional Cerebrospinal Technique (FCST), acupuncture treatment, Sacro-occipital Technique (SOT) and Chuna.We measured Cobb`s angle, Visual Analog Scale (VAS), questionnaire of TMJD and Patient Global Assessment (PGA) before and after treatment.Results:After treatment, we confirmed these improvements:One case, the Cobb`s angle correctability was 29% and the VAS was not changed, the other case, the Cobb`s angle correctability was 73% and the VAS was changed from 7~8 to 0~1, another case, the Cobb`s angle correctability was 34% and the VAS was changed from 8~9 to 0~3.Conclusions:These results suggest that FCST effective for idiopathic scoliosis.However, Randomized controlled trial of FCST will be concluded in well-designed research.