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- 저자 : 이정우 ( Myung Kum Han ) (검색결과 1 건)
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육미지황탕가갈근(六味地黃湯加葛根)이 난소적출(卵巢摘出)로 유발(誘發)된흰쥐의 골다공증(骨多孔症)에 미치는 영향
이정우 ( Myung Kum Han ),권영달 ( Jae Kyun Won ),송용선 ( Chong Woo Lee ),원재균 ( Cheol Han Kim ),김철한 ( Young Dal Kwon ),권영미 ( Yung Sun Song ),권영미 ( Young Mi Kwon ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4
Objectives :This study was performed to investigate the effects of Yukmijiwhang-tang (Liuweidihuang-tang) with Puerariae raidx(YMG) on the ovariectomized rat model of postmenopausal osteoporosis. Methods : We used 9 week aged Sprague-Dawley rat and divided into four group, sham operation group(Control, C), ovariectomized group(Negative Control, N.C), administrated YMG 1,250 mg/kg/day after ovariectomy group(T1), administrated YMG 2,500 mg/kg/day after ovariectomy group(T2). Then we observed changes in the body weight, body fat, serum metabolic products, bone density and so on. Results : 1. Body weight in negative control group showed significant increase in comparison with control group, but that in T1 and T2 group showed decrease in comparison with negative control group. 2. In the autopsy, negative control group showed uterus atrophy in comparison with control group. While T1 and T2 group showed decrease in uterus atrophy in comparison with negative control group. 3. In the total cholesterol, negative control group showed a significant increase in comparison with control group. While T1 and T2 group showed a significant decrease in comparison with negative control group. 4. In the body fat, negative control group showed a tendency to increase in comparison with control group. While T1 and T2 group showed a tendency to decrease in comparison with negative control group. 5. In bone density, normal control group showed a tendency to decrease bone density in comparison with control group. While T1 and T2 group showed a tendency to increase bone density in comparison with negative control group. Conclusions : YMG has shown to be capable of preventing and curing osteoporosis induced by ovariectomy osteoporosis rats
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