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후두암 세포주에서 $TGF-{\beta}1$에 의한 MMP2와 MMP9의 발현 양상
권남영,김형진,우정수,권순영,정광윤,Kwon Nam-Young,Kim Hyung-Jin,Woo Jeong-Su,Kwon Soon-Young,Jung Kwang-Yoon 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.2
Backgrounds and Objectives: Metastasis is a complex multistep process that requires sequential interactions between the invasive cell and the extra-cellular matrix. Transforming growth factor-${\beta}1$ ($TGF-{\beta}1$) is a multifunctional regulator of cellular differentiation, motility and growth. Loss of sensitivity to the growth inhibitory effects by $TGF-{\beta}1$ plays important roles in neoplastic progression. The aim of this study was to investigate the role of $TGF-{\beta}1$ in the neoplastic invasion and metastasis through matrix metalloproteinase (MMP) of laryngeal cancer cell lines. Material and Methods: Two laryngeal cancer cell lines, SNU-899 and SNU-1076 were treated with recombinant $TGF-{\beta}1$, and the expression of MMP-2 and MMP-9 was immunohistochemically evaluated and gelatinase activity was studied by gelatin zymogram. Results: The cell growth inhibition was evident on 4th days after 1ng/ml and 10ng/ml $TGF-{\beta}1$ treatment. The expressions of MMP-2 and MMP-9, and their gelatinase activities were increased in dose-dependent manner. Conclusion: $TGF-{\beta}1$ treatment in laryngeal cancer cell lines induces the expression of MMP-2 and MMP-9, thus playing a role in the digestion of extracellular matrix gelatin.
대학도서관 희망도서의 신청 패턴과 이용효과 분석에 관한 연구
권소담,남영준 한국정보관리학회 2018 정보관리학회지 Vol.35 No.4
대학도서관은 구성원이 교육과 연구를 수행하는 데 있어 필요수적인 자료를 선정하여 구입할 필요가 있다. 따라서 이용자의 정보 요구를 장서 개발에 반영하는 방법으로 희망도서 제도를 운영하고 있다. 본 연구는 10년간의 장기적 관점에서 희망도서 신청 과정과 결과를 분석하였다. 희망도서는 단행본에 대한 강력한 정보 요구이기 때문에 주제 분야별 이용자의 정보 요구 패턴을 파악할 수 있었다. 대학 구성원으로서 이용자는 전공하는 학문 분야에 대해서는 전공 도서를 선정하면서도 다른 주제 분야의 교양 도서를 적절히 선정하여 장서 구성에 기여하고 있었다. 결과적으로 희망도서는 소수의 이용자에 의해 선정이 이루어지지만 도서관 전체 이용자의 정보 요구를 충족시키고 있어 효율적인 장서 개발 정책으로 운용되고 있다고 볼 수 있다. Academic libraries need to select and purchase essential collections to support students and faculty in education and research. Therefore, libraries reflect patrons’ information needs on collection development through patron purchase requests. This study analyzed the pattern and efficiency of patron purchase requests in a longer-term perspective; for over a decade. Patron purchase requests show different tendencies depending on academic characteristics, which enabled libraries to identify the users’ information needs in various subjects. Typically users contributed to collection development by expressing information needs in their fields of study through purchase requests. In the meantime, users in certain fields showed interest in other subject areas besides their own to select general books on various topics. Through this study, it became evident that a major portion of library collections were affected by active purchase requests from a small number of users. However those books were proven to be in demand in terms of effectiveness. Patron-driven acquisition is being implemented as an effective collection development policy.
인산화와 초산화가 대두단백질의 기능특성과 구조에 미치는 영향
김남수,남영중,권대영 한국콩연구회 1989 韓國콩硏究會誌 Vol.6 No.1
대두단백질을 인산화 및 초산화 처리에 의하여 변형시키고, 변형 대두단백질의 기능 특성을 검토하였다. 인산화 대두단백질은 비변형 대두단백질 보다 높은 용해도, 거품특성, 수분 보유력을 나타냈다. 한편, 초산화에 의에서도 유화력과 거품 특성이 현저하게 증진되었다. 대두단백질은 인산화와 초산화에 의하여 등전점이 산성쪽으로 변하였으며 단백질의 집괴화 현상도 관찰되었다. 또한, 화학변형된 대두단백질을 디스크 전기영동에 의해 분석시 단백질 밴드의 상대 이동도가 현저하게 증대되었다.
후두암 세포주에서 TGF-β1에 의한 MMP2와 MMP9의 발현 양상
정광윤(Kwang Yoon Jung),권순영(Soon Young Kwon),우정수(Jeong Su Woo),김형진(Hyung Jin Kim),권남영(Nam Young Kwon) 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.2
Backgrounds and Objectives: Metastasis is a complex multistep process that requires sequential interactions between the invasive cell and the extra-cellular matrix. Transforming growth factor-β1 (TGF-β1) is a multifunctional regulator of cellular differentiation, motility and growth. Loss of sensitivity to the growth inhibitory effects by TGF-β1 plays important roles in neoplastic progression. The aim of this study was to investigate the role of TGF-β1 in the neoplastic invasion and metastasis through matrix metalloproteinase (MMP) of laryngeal cancer cell lines. Material and Methods: Two laryngeal cancer cell lines, SNU-899 and SNU-1076 were treated with recombinant TGF-β1 , and the expression of MMP-2 and MMP-9 was immunohistochemically evaluated and gelatinase activity was studied by gelatin zymogram. Results: The cell growth inhibition was evident on 4th days after 1ng/ml and 10ng/ml TGF-β1 treatment. The expressions of MMP-2 and MMP-9, and their gelatinase activities were increased in dose-dependent manner. Conclusion: TGF-β1 treatment in laryngeal cancer cell lines induces the expression of MMP-2 and MMP-9, thus playing a role in the digestion of extracellular matrix gelatin.