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- 저자 : 金韓坤(Han-Kon Kim) (검색결과 36 건)
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金漢坤(Kim Han Kon) 한국인구학회 1988 한국인구학 Vol.11 No.2
This study is a replication of Clemente and Sturgis' study conducted among 600 American cities in 1972. The impact of population size, physical density, social density, and age of 56 Korean cities upon the extent of their industrial diversification was analyzed. Hypotheses concerning each independent variable were generated from the theory of the development of the division of labor proposed by Durkheim and subsequently adopted by human ecologists. Zero-order correlation analysis and regression analysis were employed to test the hypotheses. The standardized partial regression coefficients indicated that social density and age of cities exert significant positive impact upon industrial diversification. On the other hand, population size showed a significant negative impact upon industrial diversification. In addition, it was discovered that the combined influence of the independent variables account for 34.6 percent of the variation in industrial diversification. The findings of this study were compared with the results of Clemente and Sturgis' study. Some suggestions for future research are presented and discussed.
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고급 화장품 소재 개발을 위한 마이크로플루딕스 기술의 잠재적 응용성
박성희 ( Sung-hee Park ),김한곤 ( Han-kon Kim ),정규혁 ( Kyu-hyuck Jeong ),김진웅 ( Jin-woong Kim ) 대한화장품학회 2008 대한화장품학회지 Vol.34 No.4
We describe here how we can use microfluidic technologies for fabricating functional materials that could be potentially utilized in cosmetics; these include void structures, functional particulate materials, shell materials, and multi-layered colloids. We can obtain these functional materials as microfluidic approaches provide precise control over both outer dimensions and inner morphology of emulsion drops in picoliter-volume scales with high throughput. We have confirmed that this technique has a great potential to fabricate novel particles and capsules with a variety of chemical compositions as well as higher orders of layers. This microfluidic approach will allow us to develop a lot of new techniques that are useful for a variety of applications, including delivery systems, chemical separations, bio-sensing, actuators, and so on. We do believe that these new techniques will help cosmetic industry not only give rise advanced functional materials and systems but also widen its product categories.
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THP-1 세포주를 이용한 화장품 원료의 피부 감작성 대체법 활용 연구
김서영 ( Seo Young Kim ),안수선 ( Su Sun An ),김한곤 ( Han Kon Kim ),이태룡 ( Tae Ryong Lee ) 한국동물실험대체법학회 2009 동물실험대체법학회지 Vol.3 No.1
Evaluation of skin sensitization potential is a major part of safety assessment of new ingredients in cosmetics and drugs to be applied topically. Several studies have shown that contact sensitizers induce co-stimulatory molecules on THP-l cells and have suggested that the expression of these co-stimulatory molecules can be used as a predictive in vitro assay system for contact sensitization. Most cosmetic ingredients are non- or slight- or at most moderate sensitizers. In this study, we evaluated the utility of the expression of co-stimulatory molecules on THP-l cells as a predictive in vitro assay system for discrimination of these slight differences in sensitizing potential of cosmetic ingredients. We investigated the expression of CD54 and/or CD86 on the THP-l cells using flow cytometry after a 24 h exposure to cosmetic ingredients such as resveratrol, polydatin (a derivative of resveratrol), and decursin with two different purities (70% and 98%). The resveratrol showed a mild skin sensitization potential and cell cytotoxicity but the polydatin did not induce any up-regulation of these two markers and did not show cell cytotoxicity at the same concentration with resveratrol. Although both decursins with 70% and 98% purities were classified as mild sensitizers, there was also a definite trend that the decursin with 98% purity was less potent sensitizer than the decursin with 70% purity. These data suggested the possibility of using expression of CD54 and/or CD86 in THP-l cell line as a predictive tool evaluating subtle differences in skin sensitization potential of cosmetic ingredients.
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장양(藏釀) 기술이 사용된 전통 고숙성 된장에서 유래한 o-Dihydroxyisoflavone 유도체의 생리활성
김동현 ( Dong Hyun Kim ),박준성 ( Jun Seong Park ),박녹현 ( Nok Hyun Park ),문은정 ( Eun Jeong Moon ),유선혜 ( Sun Hye Yu ),김덕희 ( Duck Hee Kim ),김한곤 ( Han Kon Kim ) 대한화장품학회 2009 대한화장품학회지 Vol.35 No.3
Doenjang (Korean fermented soybean paste) is a unique fermented food in Korea. It has been traditionally manufactured from soybeans, by Jang Yang process. We focused on the newly formed compound in highly aged Doenjang and its biological activity. One new o-dihydroxyisoflavone, 7,3',4'-trihydroxyisoflavone and two known o-dihydroxyisoflavone derivatives were isolated from 5-year-old Doenjang and evaluated as potent antioxidant and whitening effect by comparing with other known isoflavone. 7,8,4'-Trihydroxyisoflavone (compound 1), 7,3',4'-trihydroxyisoflavone (compound 2) and 6,7,4'-trihydroxyisoflavone (compound 3) inhibited DPPH (diphenyl- 1-picrylhydrazyl) formation by 50 % at a concentration of 21.5 ± 0.2, 28.7 ± 0.4 and 32.6 ± 0.6 (IC<sub>50</sub>) respectively, whereas daidzein showed weak DPPH radical scavenging activity. In superoxide scavenging effect were measured in one assay. Compound 1 (IC<sub>50</sub> = 18.10 ± 0.2 μM) and 2 (IC50 = 10.54 ± 0.4 μM) show significant inhibitory activity and greater effect than L-ascorbic acid. But compound 3 and daidzein showed lower inhibition activity. Also, o-dihydroxyisoflavone derivatives evaluated as potent inhibitors on tyrosinase activity and melanin formation in melan-a cells. Compound 1 (IC<sub>50</sub> = 11.21 ± 0.2 μM), compound 2 (IC<sub>50</sub> = 5.23 ± 0.6 μM) exhibited significant inhibitory effect on tyrosinase activity. Furthermore, those compounds are significantly suppressed the cellular melanin formation by 50 % at a concentration of 12.23 ± 0.7 μM (1) and 7.83 ± 0.7 μM (2). This result suggests that 7,3',4'- trihydroxyisoflavone from highly aged Doenjang could be used as an active ingredient for cosmetics.
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