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정성수(Sung Soo Jung),심종걸(Jong Geol Shim),한동수(Dong Soo Han),오기영(Ki Young Oh),김성윤(Seong Yoon Kim),김인순(In Soon Kim),박찬현(Chan Hyun Park),강종명(Chong Myung Kang),박한철(Han Chul Park),곽진영(Jin Young Kwack) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Cyclosporine treated renal transplants are known to develop hyperuricemis more frequently than azathioprine treated patients. We examined the outpatient records of all patients transplanted between April 1978 and June 1988, in whom the allograft functioned for at least one year. We did this study to determine the frequency of hyperuricemia in the renal transplants and predisposing factors. The results were as follows: 1) The serum uric acid concentration in patients in the cyclosporine treated group (8.53±2.26 mg/dl; n=33) was significantly higher than that of the azathioprine treated group (6.74±1.43mg/dl; n=24) (p<0.005). 2) The serum uric acid concentration in patients using diuretics (7.83±1.50mg/dl; n=8) was significantly higher than in those not using diuretics (6.19±1.05 mg/ dl; n=16) in the azathioprine treated group (p<0.01). 3) The serum uric acid concentration in patients using diuretics (9.95±1.74mg/dl; n=12) was significantly higher than in those without diuretics (7.59±1.97 mg/dl; n=21) in the cyclosporine treated group (p<0.005). 4) The serum uric acid concentration in patients using diuretics and azathioprine was significantly lower than that in those using diuretics and cyclosporine (p<0.05). 5) Among the patients not taking diuretics, the serum uric acid level was significantly higher in the cyclosporine treated group than in the azathioprine treated group. We conclude that there is an increased incidence of hyperuricemia in renal transplants treated with cyclosporine. This effect is thought to be due to tubular toxicity by cyclosporine. It is recommended that routine measurement of the uric acid level be done in renal transplants using cyclosporine and that diuretics be avoided in patients taking cyclosporine.