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賈春華,周春祥,王天山,崔 勳 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.5
Nae-Kyung says the puberty is corresponded to the age of 16∼24(male) and 14∼21(female). And that time they are promoted the growth. However, Kidney qi (賢氣) doesn't make average situation during that time. So, the function of five viscera and six entrails fails to be perfect and symptoms appear. I came to the conclusion through the survey of about 200 high school students(male and female) and the theory of oriental medicine the distinctive features (like migraine, amnesia, depression, dysphoria, inappetence, irregular menstruation) came out that time. I defined this distinctive symptoms in boys and girls at puberty 'synthetic symptoms of puberty'. For the medical cure and prevention I prescribed 'Sachun-Nyung' and that has medical benefits for 'Replenishing qi and relieving the spleen(益氣養陰), Soothing the liver and promoting blood circulation(疏肝活血)'
Lin, Yan,Liu, Jia,Chen, Jia,Yao, Chun,Yang, Yunwen,Wang, Jie,Zhuang, Hongqin,Hua, Zi-Chun Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.4
Our previous study revealed a novel role of Fas-associated death domain-containing protein (FADD) in islet development and insulin secretion. Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes (T2DM). The current study was designed to investigate the effect of FADD phosphorylation on IDE. We found that the mRNA and protein levels of IDE were significantly downregulated in FADD-D mouse livers compared with control mice. Quantitative real-time polymerase chain reaction analysis showed that FADD regulates the expression of IDE at the transcriptional level without affecting the stability of the mRNA in HepG2 cells. Following treatment with cycloheximide, the IDE protein degradation rate was found to be increased in both FADD-D primary hepatocytes and FADD-knockdown HepG2 cells. Additionally, IDE expression levels were reduced in insulin-stimulated primary hepatocytes from FADD-D mice compared to those from control mice. Moreover, FADD phosphorylation promotes nuclear translocation of FoxO1, thus inhibiting the transcriptional activity of the IDE promoter. Together, these findings imply a novel role of FADD in the reduction of protein stability and expression levels of IDE.
Ke Ding,Ke Shang,Zu-Hua Yu,Chuan Yu,Yan-Yan Jia,Lei He,Cheng-Shui Liao,Jing Li,Chun-Jie Zhang,Yin-Ju Li,Ting-Cai Wu,Xiang-chao Cheng 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.2
Newcastle disease virus (NDV) and Salmonella Pullorum have significant damaging effects on the poultry industry, but no previous vaccinecan protect poultry effectively. In this study, a recombinant-attenuated S. Pullorum strain secreting the NDV hemagglutinin-neuraminidase(HN) protein, C79-13ΔcrpΔasd (pYA-HN), was constructed by using the suicide plasmid pREasd-mediated bacteria homologousrecombination method to form a new bivalent vaccine candidate against Newcastle disease (ND) and S. Pullorum disease (PD). The effectof this vaccine candidate was compared with those of the NDV LaSota and C79-13ΔcrpΔasd (pYA) strains. The serum hemagglutinationinhibition antibody titers, serum immunoglobulin G (IgG) antibodies, secretory IgA, and stimulation index in lymphocyte proliferation wereincreased significantly more (p < 0.01) in chickens inoculated with C79-13ΔcrpΔasd (pYA-HN) than with C79-13ΔcrpΔasd (pYA) but werenot significantly increased compared with the chickens immunized with the LaSota live vaccine (p > 0.05). Moreover, the novel strain provides60% and 80% protective efficacy against the NDV virulent strain F48E9 and the S. Pullorum virulent strain C79-13. In summary, in this study,a recombinant-attenuated S. Pullorum strain secreting NDV HN protein was constructed. The generation of the S. Pullorum C79-13ΔcrpΔasd(pYA-HN) strain provides a foundation for the development of an effective living-vector double vaccine against ND and PD.
Mei-Feng Lai,Chen-Hung Huang,Jia-Horng Lin,Yu-Chun Chuang,Ching-Hua Wang,Ching-Wen Lou 한국섬유공학회 2021 Fibers and polymers Vol.22 No.9
In this study, conductive polymer composites and conductive functional fabrics are combined to serve aselectromagnetic shielding planks. Polypropylene (PP), carbon black (CB), and short carbon fibers (SCF) are blended atdifferent ratios to form conductive polymer composites (i.e. PCS series). The mechanical property, electrical property,morphology, and electromagnetic interference shielding effectiveness (EMI SE) of the PCS series are evaluated. The testresults show that with 20 wt% of conductive fillers (i.e. CB and SCF), PCS20 exhibits the optimal tensile strength, flexuralstrength, and electrical property that is 7 order of magnitude higher than that of pure PP plates. Moreover, the EMI SE of thisgroup also reaches -30 dB, which meets level one of civil EMI SE standard. Therefore, PCS20 is used to combine with fourconductive sandwiches. The resulting multilayered functional PCS-sandwich planks are tested in terms of mechanicalproperty, morphology, and EMI SE. The test results show that the planks composed of a pure conductive woven sandwichhave the maximum tensile property and significantly improved impact resistance. All of the multilayered functional plankshave EMI SE that is higher than -50 dB and are qualified for the protection level of standard EMI SE electronic devices.
Genetic Epidemiological Analysis of Esophageal Cancer in High-incidence Areas of China
Wang, Kai-Juan,Yang, Jun-Xia,Shi, Jia-Chen,Deng, Song-Yuan,Cao, Xiao-Qin,Song, Chun-Hua,Wang, Peng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second-degree relatives was $67.0{\pm}7.31%$ and $43.1%{\pm}9.80%$, respectively, and the summing up powered heritability was $53.2{\pm}6.74%$. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.
Zhang, You-Gai,Shi, Jian-Xiang,Song, Chun-Hua,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Shi, Jia-Chen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Meta-analyses have shown that microRNA polymorphisms have variable effects in different population. Yet, no meta-analysis investigated the association of two common polymorphisms of miRNA, mir-499 rs3746444 polymorphism and mir-149 rs2292832 polymorphism, with cancer risk in the Chinese population. We searched the PubMed, Web of Knowledge, MEDLINE, CNKI databases, as well as Cochrane library, updated on December 31, 2012 for assays regarding cancer risk association with these two common polymorphisms in the present meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to explore the strength of associations. The results showed that rs3746444 polymorphism was associated with increased cancer risk (dominant model: GG/AG vs. AA: OR = 1.43, 95% CI: 1.14-1.80; recessive model: GG vs. AG/AA: OR = 1.54, 95% CI: 1.04-2.30; homozygote model: GG vs. AA: OR = 1.69, 95% CI: 1.10-2.60; heterozygote model: AG vs. AA: OR = 1. 35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cancer types. For the rs2292832 polymorphism, the results showed no significant risk association in both overall pooled analysis and subgroup of cancer types, smoking status, gender and tea drinking status in the Chinese population. This meta-analysis suggested that the rs3746444 GG genotype is associated with increased cancer risk, especially liver cancer, while the rs2292832 polymorphism showed no association with cancer risk in Chinese.
論文 : 從『黃帝內經』腎之功能探析『金궤궤要略』腎氣丸氣化作用的體現
( Eun Hee Park ),( Jing Xie ),( Chun Hua Jia ) 대한한의학원전학회(구 대한원전의사학회) 2013 대한한의학원전학회지 Vol.26 No.1
Objective: This article is based on a formula taken from Essential Prescriptions of the Golden Chamber(金궤要略). Shen Qi Pill(腎氣丸) is generally used for such deficiency cases as: consumptive diseases, xiaoke(消渴) (waisting, thirst), beriberi, urinary problems during pregnancy, phlegm and so forth, and its main purpose is to treat Kidney Qi depletion, Qi transformation disorders, without obvious hot/cold appearance patterns. Method: Mainly through the literature study of related treatise on IInner Canon of the Yellow Emperor`s internal classic(黃帝內經) and The Essential Prescriptions of the Golden Chamber. Result: According to the Yellow Emperor`s internal classic, the Kidney has three main functions, storing essence, controlling the waters and holding Qi. Shen Qi Pill`s(腎氣丸) source formula is intended to supplement even though its constituent herbs aren`t the warming type. To reinforce the Qi`s transformation ability is considered to be a main function of the kidney organ, and in clinic, diagnosed kidney related problems and its treatment process are mainly associated with warming to help the Qi transforming. Conclusion: Thus recovering the kidneys Qi`s transformation function is part of the process to eliminate diseases. Just cause the Kidney is deficient we shouldn`t think immediately of using warming supplement herbs.
Song, Chuan-Qing,Zhang, Jun-Hui,Shi, Jia-Chen,Cao, Xiao-Qin,Song, Chun-Hua,Hassan, Adil,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Wang, Kai-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Polymorphisms in miRNA binding sites have been shown to affect miRNA binding to target genes, resulting in differential mRNA and protein expression and susceptibility to common diseases. Our purpose was to predict SNPs (single nucleotide polymorphisms) within miRNA binding sites of inflammatory genes in relation to gastric cancer. A complete list of SNPs in the 3'UTR regions of all inflammatory genes associated with gastric cancer was obtained from Pubmed. miRNA target prediction databases (MirSNP, Targetscan Human 6.2, PolymiRTS 3.0, miRNASNP 2.0, and Patrocles) were used to predict miRNA target sites. There were 99 SNPs with MAF>0.05 within the miRNA binding sites of 41 genes among 72 inflammation-related genes associated with gastric cancer. NF-${\kappa}B$ and JAK-STAT are the two most important signaling pathways. 47 SNPs of 25 genes with 95 miRNAs were predicted. CCL2 and IL1F5 were found to be the shared target genes of hsa-miRNA-624-3p. Bioinformatic methods could identify a set of SNPs within miRNA binding sites of inflammatory genes, and provide data and direction for subsequent functional verification research.