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Yeom, J.H.,Joo, M.,Lee, B.,Kim, K.P.,Ha, N.C.,Park, Y.,Bae, J.,Lee, K. THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2017 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.45 No.-
<P>Here, we report that the gold nanoparticle-DNA aptamer (AuNP-Apt) conjugate-based system can efficiently deliver recombinant proteins into mammalian cells in a manner independent of their size, isoelectric point, and cellular localization. Additionally, AuNP-Apt system-assisted protein delivery can be effective on primary and stem cells, indicating that its use is not limited to fast-dividing cells. We further show that the intravenously administered AuNP-Apt system can deliver proteins into rat organs. Our findings show that this system can serve as a simple, efficient, and versatile platform for the delivery of recombinant proteins into mammalian living systems. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>
Ko, J.,Jeong, H.,Choi, S.Y.,Rotermund, F.,Yeom, D.I.,Kim, B.Y. Elsevier 2017 CURRENT APPLIED PHYSICS Vol.17 No.1
<P>We demonstrated four different laser operational states in the same passive fiber ring laser cavity by controlling solely the polarization state in a saturable absorber. The demonstrated laser operational states were continuous wave, mode-locking, Q-switching, and Q-switched mode-locking. The saturable absorber was fabricated by spin-coating a single-walled carbon nanotubes (SWCNT)/polymer composite on a side polished fiber providing enhanced nonlinear interaction with the SWCNT. The wide tuning range of the saturable absorber allows the simple means to generate different forms of laser output from a single laser cavity. (C) 2016 Elsevier B. V. All rights reserved.</P>
One‐Step Multipurpose Surface Functionalization by Adhesive Catecholamine
Kang, Sung Min,Hwang, Nathaniel S.,Yeom, Jihyeon,Park, Sung Young,Messersmith, Phillip B.,Choi, Insung S.,Langer, Robert,Anderson, Daniel G.,Lee, Haeshin WILEY‐VCH Verlag 2012 Advanced functional materials Vol.22 No.14
<P><B>Abstract</B></P><P>Surface modification is one of the most important techniques in modern science and engineering. The facile introduction of a wide variety of desired properties onto virtually any material surface is an ultimate goal in surface chemistry. To achieve this goal, the incorporation of structurally diverse molecules onto any material surface is an essential capability for ideal surface modification. Here, a general strategy for surface modification is presented in which many diverse surfaces can be functionalized by immobilizing a wide variety of molecules. This strategy functionalizes surfaces by a one‐step immersion of substrates in a one‐pot mixture of a molecule and a catecholamine surface modification agent. This one‐step procedure for surface modification represents a standard protocol to control interfacial properties.</P>
Oh, M.C.,Yeom, H.,Jeon, Y.,Ahn, B. PAS 2015 ARCHIVES OF METALLURGY Vol.60 No.2
<B>Abstract</B><P>The influence of surface heat treatment using laser radiation on the fatigue strength and corresponding microstructural evolution of AISI 4140 alloy steel was investigated in this research. The AISI 4140 alloy steel was radiated by a diode laser to give surface temperatures in the range between 600 and 800°C, and subsequently underwent vibration peening. The fatigue behavior of surface-treated specimens was examined using a giga-cycle ultrasonic fatigue test, and it was compared with that of non-treated and only-peened specimens. Fatigue fractured surfaces and microstructural evolution with respect to the laser treatment temperatures were investigated using an optical microscope. Hardness distribution was measured using Vickers micro-hardness. Higher laser temperature resulted in higher fatigue strength, attributed to the phase transformation.</P>
Diaz, Melvin B.,Kim, Kwang Yeom,Kang, Tae-Ho,Shin, Hyu-Soung Elsevier 2018 Geothermics Vol.72 No.-
<P><B>Abstract</B></P> <P>Drilling parameters are analyzed here to improve forecasting of the rate of penetration (ROP) in enhanced geothermal systems (EGSs). Data recorded during drilling a 4.2-km-deep well at a pilot EGS project in South Korea were analyzed. The greatly fluctuating ROP values were smoothed using a fast Fourier transform filter. Two drilling optimization methods (multiple regression and artificial neural networks) then evaluated the effect of smoothing: it improved ROP prediction in both cases, with over 90% correlation at relatively low degrees of filtering. A methodology to optimize the degree of smoothness for a given drilling data set is suggested.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analysis of drilling parameters recorded during drilling of a 4.2 km depth well. </LI> <LI> The drilling data comes from an Enhanced Geothermal System (EGS) project. </LI> <LI> The fluctuating ROP recorded values were smoothed using an FFT filter. </LI> <LI> Multiple regression and a neural network evaluated the filtering effect on ROP prediction. </LI> <LI> A methodology to optimize the degree of smoothness is suggested. </LI> </UL> </P>
<i>Ab initio</i>study of incorporation ofO2molecules intoSi(001)surfaces: Oxidation bySiejection
Yu, B. D.,Kim, Young Jin,Jeon, Junjin,Kim, Hanchul,Yeom, H. W.,Lyo, I. W.,Kong, Ki-jeong,Miyamoto, Y.,Sugino, O.,Ohno, T. American Physical Society 2004 Physical review. B, Condensed matter and materials Vol.70 No.3
Ginsenoside Rb1 rescues anxiety-like responses in a rat model of post-traumatic stress disorder
Lee, B.,Sur, B.,Cho, S. G.,Yeom, M.,Shim, I.,Lee, H.,Hahm, D. H. Springer Science + Business Media 2016 Journal of Natural Medicines Vol.70 No.2
<P>Single prolonged stress (SPS), a rat model of post-traumatic stress disorder (PTSD), induces alterations in the hypothalamic-pituitary-adrenal axis. Korean red ginseng, whose major active component is ginsenoside Rb1 (GRb1), is one of the widely used traditional anxiolytics. However, the efficacy of GRb1 in alleviating PTSD-associated anxiety-like abnormalities has not been investigated. The present study used several behavioral tests to examine the effects of GRb1 on symptoms of anxiety in rats after SPS exposure and on the central noradrenergic system. Male Sprague-Dawley rats received GRb1 (10 or 30 mg/kg, i.p., once daily) during 14 days of SPS. Daily GRb1 (30 mg/kg) administration significantly increased the number and duration of open-arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, reduced grooming behaviors in the EPM test, and increased the total number of line crossings of an open field after SPS. The higher dose of GRb1 also blocked SPS-induced decreases in hypothalamic neuropeptide Y expression, increases in locus coeruleus tyrosine hydroxylase expression, and decreases in hippocampal mRNA expression of brain-derived neurotrophic factor. These findings suggest that GRb1 has anxiolytic-like effects on both behavioral and biochemical symptoms similar to those observed in patients with PTSD.</P>