Risk of Second Primary Cancer in People with Non-melanoma Skin Cancer: A Nationwide Cohort Study

Shu-Hui Wang,Ching-Chi Chi,Zi-Hao Zhao,Tao-Hsin Tung 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2

Purpose Previous western studies have found Caucasians with skin cancer, either melanoma or nonmelanoma skin cancer (NMSC), have an elevated risk of second primary cancer. Our objective was to assess the risk of second primary cancer in Taiwanese with NMSC. Materials and Methods By using data from Taiwan’s National Health Insurance Research Database, we conducted a population-based cohort study to assess the risk of incident second primary cancer in Taiwanese affected by NMSC. Results We identified 505 subjects with NMSC and 2,020 matched controls. After adjustment for potential confounders including age, sex, urbanization, and Charlson Comorbidity Index, people who had NMSC had a 1.43-fold (95% confidence interval [CI], 1.05 to 1.96) risk for the development of second primary cancer as compared with control group. Men with NMSC had a 2.99-fold (95% CI, 1.00 to 9.10) risk for second primary cancer involving the lip, oral cavity, and pharynx and a 3.51-fold (95% CI, 1.21 to 10.17) risk for second primary cancer involving the genitourinary organs when compared to the control group. By contrast, women with NMSC did not have an increased risk of second primary cancer. Conclusion This study revealed Asians with NMSC have an increased risk of second primary cancer. Our findings can be a useful reference for health care for people diagnosed with NMSC.

Screening of Nitrosamine Impurities in Sartan Pharmaceuticals by GC-MS/MS

( Shu-Han Chang ),( Hui-Yu Ho ),( Chi-Zong Zang ),( Ya-Hui Hsu ),( Mei-Chih Lin ),( Su-Hsiang Tseng ),( Der-Yuan Wang ) 한국질량분석학회 2021 Mass spectrometry letters Vol.12 No.2

Probable human carcinogenic compounds nitrosamines, have been detected as by-product impurities in sartan pharmaceuticals in recent years which has drawn worries for medication safety. To provide a sensitive and effective method for the quality control of sartan pharmaceuticals, this study established a feasible gas chromatography-tandem mass spectrometry (GC-MS/MS) method for simultaneous determination of 13 nitrosamines. The target analytes were separated on a DB-WAX Ultra Inert column (30 m × 0.25 mm; i.d., 0.25 μm) and were then subjected to electron impact ionization in multiple reaction monitoring mode. The established method was validated and further employed to analyze authentic samples. Limits of detection (LODs) and limits of quantification (LOQs) of the 13 nitrosamines were 15-250 ng/g and 50-250 ng/g, respectively, which also exhibited intra-day and inter-day accuracies of 91.4-104.8%, thereby satisfying validation criteria. Five nitrosamines, viz., Nnitrosodiethylamine, N-nitrosodimethylamine, N-nitrosodiphenylamine, N-nitrosomorpholine, and N-nitrosopiperidine were detected at concentrations above their LODs in 68 positive samples out of 594 authentic samples from seven sartans.

Poster Presentations : Basic Research, Parenteral Nutrition ; Clinical Experience of Zinc Deficiency

( Shu Ling Tsai ),( Tzu Chi Hsu ),( Chyong Shi Wang ),( Chiang Chao ),( Tsang En Wang ) 한국정맥경장영양학회 2005 The 11th PENSA Congress Vol.2005 No.-

Extensive Power Factor Calculation Method Using FPGA Considering Power Quality Disturbance

SHU-CHEN WANG,CHI-JUI WU 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

The power quality is more and more serious, because a lot of information technology equipments and power electric converters were used in recent years. Harmonic and load unbalance can affect the measurement result of power factor of utility. This paper used six formulas for power factor measurement, and they will be different according to the characteristics of load. The technology of semiconductor was more and more maturely. Design of SOC (System On a Chip) is a trend to achieve the strong and small volume in the future. The Fast Fourier Transform (FFT) is used to analyze the six formula of power factor. The simulation system was modeled in Hardware Description Language (VHDL) and some novel IP (intellectual property) cores, such as CORDIC core and FFT core by the way of Bottom-Up. The measurement data were employed to calculate active, reactive and apparent power. The average error rate of our design is about 0.05%.

Analysis of Power System QV Curve by Fuzzy Modeling

SHU-CHEN WANG,CHI-JUI WU,PEI-HWA HUANG 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

Voltage instability of power system comes from increasing load rapidly, and causes bus voltage to drop. When voltage is out of control and it can be voltage collapse. This paper presents the fuzzy modeling approach to the description QV curve of power system for analysis of voltage stability. The QV curve can identify voltage stability limit, and it determine robustness of power system. The fuzzy system model is basically a collection of fuzzy IF-THEN rules that are combined via fuzzy reasoning for describing the features of a system under study. The method of fuzzy modeling has been proven to be well-suited for modeling nonlinear industrial processes described by input-output data. In view of the nonlinear characteristic of the QV curve, the method of fuzzy modeling is employed for representing the curve. Based on the Sugeno-type fuzzy model, various models with different numbers of modeling rules are used to describing the QV curve. It is found that such fuzzy model offers both quantitative and qualitative descriptions for the QV curve.

The Effectiveness of Dignity Therapy as Applied to End-of-Life Patients with Cancer in Taiwan: A Quasi-Experimental Study

Yu-Chi Li,Yin-Hsun Feng,Hui-Ying Chiang,Shu-Ching Ma,Hsiu-Hung Wang 한국간호과학회 2020 Asian Nursing Research Vol.14 No.4

Purpose: The aim of the study was to determine the effectiveness of dignity therapy for end-of-lifepatients with cancer. Methods: This study used a quasi-experimental study design with a nonrandomized controlled trial. Dignity therapy was used as an intervention in the experimental group, and general visit was used in thecontrol group. Thirty end-of-life patients with cancer were recruited, with 16 in the experimental groupand 14 in the control group. Outcome variables were the participants' dignity, demoralization, anddepression. Measurements were taken at the following time points: pre-test (before intervention), posttest1 (the 7th day), and post-test 2 (the 14th day). The effectiveness of the intervention in the twogroups was analyzed using the generalized estimating equation, with the p value set to be less than .05. Results: After dignity therapy, the end-of-life patients with cancer reflected increased dignity significantly[b ¼ 37.08, standard error (SE) ¼ 7.43, Wald c2 ¼ 24.94, p < .001], whereas demoralization(b¼ 39.55, SE ¼ 6.42,Wald c2 ¼ 37.95, p < .001) and depression (b¼ 12.01, SE ¼ 2.17,Wald c2 ¼ 30.71,p < .001) were both reduced significantly. Conclusion: Clinical nurses could be adopting dignity therapy to relieve psychological distress andimprove spiritual need in end-of-life patients with cancer. Future studies might be expanded tolooking at patients vis- a-vis end-of-life patients without cancer to improve their psychologicaldistress. These results provide reference data for the care of end-of-life patients with cancer fornursing professionals.

Safety and Efficacy of Adalimumab for Patients With Moderate to Severe Crohn`s Disease: The Taiwan Society of Inflammatory Bowel Disease (TSIBD) Study

( Chen Wang Chang ),( Shu Chen Wei ),( Jen Wei Chou ),( Tzu Chi Hsu ),( Chiao Hsiung Chuang ),( Ching Pin Lin ),( Wen Hung Hsu ),( Hsu Heng Yen ),( Jen Kou Lin ),( Yi Jen Fang ),( Horng Yuan Wang ),( 대한장연구학회 2014 Intestinal Research Vol.12 No.4

Background/Aims: Only moderate to severe Crohn`s Disease (CD) patients without a satisfactory conventional therapy effect are eligible to get reimbursement from the National Health Insurance of Taiwan for using adalimumab. These are more stringent criteria than in many Western countries and Japan and Korea. We aim to explore the efficacy of using adalimumab in CD patients under such stringent criteria. Methods: A retrospective analysis was conducted in nine medical centers in Taiwan and we collected the results of CD patients receiving adalimumab from Sep 2009 to Mar 2014. The clinical characteristics, response measured by CDAI (Crohn`s Disease Activity Index), adverse events and survival status were recorded and analyzed. CR-70, CR-100, and CR-150 were defined as attaining a CDAI decrease of 70, 100 or 150 points compared with baseline. Results: A total of 103 CD patient records were used in this study. Sixty percent of these patients received combination therapy of adalimumab together with immunomodulators. CR-70 was 68.7%, 74.5% and 88.4% after week 4, 8 and 12 of treatment, respectively. The steroid-free rate, complications and survival were 47.6%, 9.7% and 99% of patients, respectively. In considering the mucosal healing, only 25% patients achieve mucosal healing after treatment for 6 to12 months. Surgery was still needed in 16.5% of patients. Combination treatment of adalimumab with immunomodulators further decreased the level of CDAI at week 8 when compared with the monotherapy. Conclusions: Even under the stringent criteria for using adalimumab, the response rate was comparable to those without stringent criteria. (Intest Res 2014;12:287-292)

Studies on Antimutagenicity and Anticarcinogenicity of Green Tea Antioxidant

Cheng Shu-Jun,Gao Yan-Ning,Ho Chi-Tang,Wang Zhi-Yuan 한국식품과학회 1989 식품과학과 산업 Vol.22 No.3

Dignity and Related Factors in Patients with Cancer: A Cross-Sectional Study

Li Yu-Chi,Feng Yin-Hsun,Ma Shu-Ching,Wang Hsiu-Hung 한국간호과학회 2023 Asian Nursing Research Vol.17 No.1

Purpose: Dignity is a basic human right that is related to psychological distress factors in patients with cancer such as depression and demoralization. Hence, the dignity issue is of great importance to healthcare professionals. The present study aimed to advise healthcare professionals regarding the related distress factors of dignity in patients with cancer by investigating its relationship with patients’ demographics, disease characteristics, and psychological distress. Methods: This was a cross-sectional study design. A convenience sample of 267 patients with cancer from a medical center was recruited into this study. Each patient completed demographics and disease characteristics questionnaires, the Patient Dignity Inventory Mandarin Version, the Demoralization Scale Mandarin Version (DS-MV), and the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed with SPSS 22.0 software. Results: Dignity was significantly correlated with age, demoralization, and depression. Cancer patients aged 65 or above were more likely to have a lower sense of dignity. In the present study, the sensitivity and specificity of the Patient Dignity Inventory Mandarin Version for demoralization (DS-MVꠑ30) were 84.8% and 79.1% and for depression (PHQ-9ꠑ10) were 73.8% and 70.9% in patients with cancer with an aggregate score of 35 or above. Conclusions: Dignity is significantly correlated with personal demographic characteristics and psychoꠓlogical distress in patients with cancer. The results provide reference data for healthcare professionals to understand and enable dignity in patients with cancer and aid in the development of methods that promote their dignity

Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose-induced apoptosis

Chien-Wen Chian,Yung-Shu Lee,Yi-Ju Lee,Ya-Hui Chen,Chi-Ping Wang,Wen-Chin Lee,Huei-Jane Lee 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5

Diabetic nephropathy (DN) is a hyperglycemia-induced progressive development of renal insufficiency. Excessive glucose can increase mitochondrial reactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction. Our previous study indicated that cilostazol (CTZ) can reduce ROS levels and decelerate DN progression in streptozotocin (STZ)-induced type 1 diabetes. This study investigated the potential mechanisms of CTZ in rats with DN and in high glucose-treated mesangial cells. Male Sprague-Dawley rats were fed 5 mg/kg/day of CTZ after developing STZ-induced diabetes mellitus. Electron microscopy revealed that CTZ reduced the thickness of the glomerular basement membrane and improved mitochondrial morphology in mesangial cells of diabetic kidney. CTZ treatment reduced excessive kidney mitochondrial DNA copy numbers induced by hyperglycemia and interacted with the intrinsic pathway for regulating cell apoptosis as an antiapoptotic mechanism. In high-glucose-treated mesangial cells, CTZ reduced ROS production, altered the apoptotic status, and down-regulated transforming growth factor beta (TGF-β) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). Base on the results of our previous and current studies, CTZ deceleration of hyperglycemia-induced DN is attributable to ROS reduction and thereby maintenance of the mitochondrial function and reduction in TGF-β and NF-κB levels.