Improved interfacial stress analysis of a plated beam

Sheng-Wang Hao,Yan Liu,Xiao-Dan Liu 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

A plated beam is strengthened by bonding a thin plate to the tension face; it often fails because of premature debonding of the thin plate from the original beam in a brittle manner. A sound understanding of the mechanism of such debonding failure is very important for the effective use of this strengthening technique. This paper presents an improved analytical solution for interfacial stresses that incorporates multiple loading conditions simultaneously, including prestress, mechanical and thermal loads, and the effects of adherend shear deformations and curvature mismatches between the beam and the plate. Simply supported beams bonded with a thin prestressing plate and subjected to both mechanical and thermal loading were considered in the present work. The effects of the curvature mismatch and adherend shear deformations of the beam and plate were investigated and compared. The main mechanisms affecting the distribution of interfacial stresses were analyzed. Both the normal and shear stresses were found to be significantly influenced by the coupled effects of the elastic moduli with the ratios Ea/Eb and Ea/Ep.

STAR FORMATION LAWS IN BOTH GALACTIC MASSIVE CLUMPS AND EXTERNAL GALAXIES: EXTENSIVE STUDY WITH DUST CONINUUM, HCN (4-3), AND CS (7-6)

Liu, Tie,Kim, Kee-Tae,Yoo, Hyunju,Liu, Sheng-yuan,Tatematsu, Ken’ichi,Qin, Sheng-Li,Zhang, Qizhou,Wu, Yuefang,Wang, Ke,Goldsmith, Paul F.,Juvela, Mika,Lee, Jeong-Eun,Tó,th, L. Viktor,Mardones, D American Astronomical Society 2016 The Astrophysical journal Vol.829 No.2

<P>We observed 146 Galactic clumps in HCN (4-3) and CS (7-6) with the Atacama Submillimeter Telescope Experiment 10 m telescope. A tight linear relationship between star formation rate and gas mass traced by dust continuum emission was found for both Galactic clumps and the high redshift (z > 1) star forming galaxies (SFGs), indicating a constant gas depletion time of similar to 100 Myr for molecular gas in both Galactic clumps and high z SFGs. However, low z galaxies do not follow this relation and seem to have a longer global gas depletion time. The correlations between total infrared luminosities (L-TIR) and molecular line luminosities (L-mol') of HCN (4-3) and CS (7-6) are tight and sublinear extending down to clumps with L-TIR similar to 10(3) L-circle dot. These correlations become linear when extended to external galaxies. A bimodal behavior in the L-TIR-L-mol' correlations was found for clumps with different dust temperature, luminosity-to-mass ratio, and sigma(line)/sigma(vir). Such bimodal behavior may be due to evolutionary effects. The slopes of L-TIR-L-mol' correlations become more shallow as clumps evolve. We compared our results with lower J transition lines in Wu et al. (2010). The correlations between clump masses and line luminosities are close to linear for low effective excitation density tracers but become sublinear for high effective excitation density tracers for clumps with L-TIR larger than L-TIR similar to 10(4.5) L-circle dot. High effective excitation density tracers cannot linearly trace the total clump masses, leading to a sublinear correlations for both M-clump-L-mol' and L-TIR-L-mol' relations.</P>

Effects of Ribosomal Protein L39-L on the Drug Resistance Mechanisms of Lung Cancer A549 Cells

Liu, Hong-Sheng,Tan, Wen-Bin,Yang, Ning,Yang, Yuan-Yuan,Cheng, Peng,Liu, Li-Juan,Wang, Wei-Jie,Zhu, Chang-Liang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: Cancer is a major threat to the public health whether in developed or in developing countries. As the most common primary malignant tumor, the morbidity and mortality rate of lung cancer continues to rise in recent ten years worldwide. Chemotherapy is one of the main methods in the treatment of lung cancer, but this is hampered by chemotherapy drug resistance, especially MDR. As a component of the 60S large ribosomal subunit, ribosomal protein L39-L gene was reported to be expressed specifically in the human testis and human cancer samples of various tissue origins. Materials and Methods: Total RNA of cultured drug-resistant and susceptible A549 cells was isolated, and real time quantitative RT-PCR were used to indicate the transcribe difference between amycin resistant and susceptible strain of A549 cells. Viability assay were used to show the amycin resistance difference in RPL39-L transfected A549 cell line than control vector and null-transfected A549 cell line. Results: The ribosomal protein L39-L transcription level was 8.2 times higher in drug-resistant human lung cancer A549 cell line than in susceptible A549 cell line by quantitative RT-PCR analysis. The ribosomal protein L39-L transfected cells showed enhanced drug resistance compared to plasmid vector-transfected or null-transfected cells as determined by methyl tritiated thymidine (3H-TdR) incorporation. Conclusions and Implications for Practice: The ribosomal protein L39-L gene may have effects on the drug resistance mechanism of lung cancer A549 cells.

Construction and Expression of an Eukaryotic Expression Vector Containing the IER3 Gene

Wang, Zhen,Yu, Hong-Sheng,Yao, Ru-Yong,Qiu, Wen-Sheng,Yue, Lu,Sui, Ai-Hua,Liu, Xiang-Ping,Liu, Shi-Hai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: More and more research indicate that the immediately early response gene 3 (IER3) is involved inmany biological provesses, such as apoptosis and immunoreaction, as well as viral infection, tumorigenesis and tumour progression. Methods: Here we describe the construction of an eukaryotic expression vector containing IER3 gene and its expression in A549 cells as assessed through fluorescence microscopyand Western-blotting. Results: Fluorescence detection displayed that GFP in cytoplasm was high during 48 and 72 hours post-transfection. In addition, Western blotting showed significant increase in IER3 gene expression in the transfected cells compared with controls. Conclusion: The recombinate plasmid expression vector was constructed successfully, which may provide a basis for further exploration of function of IER3 in lung cancer.

Measurement of Road Surface Irregular Crack Width Based on Ferret and Second Order Moment

Liu Sheng,Wang Weixing,Wang Fengping 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.12

In order to evaluate the damage of the road accurately, a Ferret subsection measurement method based on Invariantmoment was proposed. First, it set a Ferret minimum external rectangular on the basis of the barycenter and spindle. The rectangular width was the result of crack width. It set the edge conditions for reducing the errors of measurement caused by the slender burrs. It allowed rectangular edge and targets to intersect. In order to section reasonably, a method based on distance map was proposed. In the extreme value points, the subsections image was finished. It ensured that the distance between two adjacent lines was longer than the crack width. Experimental data indicated that the percent of valuable information was higher, the measurement was accurate. It can meet the requirement of practical engineering.

ALMA Reveals Sequential High-mass Star Formation in the G9.62+0.19 Complex

Liu, Tie,Lacy, John,Li, Pak Shing,Wang, Ke,Qin, Sheng-Li,Zhang, Qizhou,Kim, Kee-Tae,Garay, Guido,Wu, Yuefang,Mardones, Diego,Zhu, Qingfeng,Tatematsu, Ken’ichi,Hirota, Tomoya,Ren, Zhiyuan,Liu, Sheng-Yu American Astronomical Society 2017 The Astrophysical journal Vol.849 No.1

<P>Stellar feedback from high-mass stars (e.g., H II regions) can strongly influence the surrounding interstellar medium and regulate star formation. Our new ALMA observations reveal sequential high-mass star formation taking place within one subvirial filamentary clump (the G9.62 clump) in the G9.62+0.19 complex. The 12 dense cores (MM1-MM12) detected by ALMA are at very different evolutionary stages, from the starless core phase to the UC H II region phase. Three dense cores (MM6, MM7/G, MM8/F) are associated with outflows. The mass-velocity diagrams of the outflows associated with MM7/G and MM8/F can be well-fit by broken power laws. The mass-velocity diagram of the SiO outflow associated with MM8/F breaks much earlier than other outflow tracers (e.g., CO, SO, CS, HCN), suggesting that SiO traces newly shocked gas, while the other molecular lines (e.g., CO, SO, CS, HCN) mainly trace the ambient gas continuously entrained by outflow jets. Five cores (MM1, MM3, MM5, MM9, MM10) are massive starless core candidates whose masses are estimated to be larger than 25 M-circle dot, assuming a dust temperature of <= 20 K. The shocks from the expanding H II regions ('B' and 'C') to the west may have a great impact on the G9.62 clump by compressing it into a filament and inducing core collapse successively, leading to sequential star formation. Our findings suggest that stellar feedback from H II regions may enhance the star formation efficiency and suppress low-mass star formation in adjacent pre-existing massive clumps.</P>

Starving Aphelinus asychis negatively affects host feeding and parasitism on Myzus persicae

Sheng-Yin Wang,Yi Feng,Ning-Ning Liang,Rui Tang,Yan-Hong Liu,Da Yu Zhang,Tong-Xian Liu 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2

Aphelinus asychis (Walker) is an effective biological control agent for many species of aphids found on various crops. To provide strategies for releasing these parasitoids into a crop ecosystem, the effects of a short-duration starvation experiment on A. asychis were measured under laboratory conditions using Myzus persicae (Sulzer) as the host on cabbage and chili pepper plants. The survival rate of starved A. asychis female adults decreased sharply as the starving time increased, and the longevity of the starved parasitoids also decreased significantly. The number of aphids killed by the parasitoids decreased gradually with the extended duration of starvation. In addition, the number of aphids on chili peppers and cabbages killed by starved A. asychis females over their lifespan was significantly lower than that in the control group. Our results indicated that a short period of starvation might not cause significantly negative effects on the parasitoids and may be beneficial for the control of M. persicae at low densities after 1 day; however, starvation for>1 day seriously affected the performance of A. asychis females over their entire lifespan. The parasitoids performed similarly when aphids were fed chili pepper or cabbage plants.

Correlation between population size of pear Psylla (Cacopsylla chinensis) and leaf structure features in different pear cultivars

Sheng-jie Xu,Lun Wu,Qi Zhi Liu,Jun Liu,He Wang,Jie-wen Wang,Ting Zhang 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

The feeding preference of pear psylla (Cacopsylla chinensis) varies among pear cultivars. To clarify whether leaf structural factors are related to C. chinensis resistance, eleven pear cultivars of three pear species and their hybrids in China were studied. The population size of C. chinensis in plots of different cultivars was investigated, and leaf paraffin sections of each pear cultivar were observed. Correlation analysis results showed that the thickness of palisade tissue (PT) and the thickness ratio (TR) of PT to leaf (L) were the main factors influencing resistance to C. chinensis. The leaves of cultivar Wujiuxiang and those species from France and the USA exhibited the thickest PT and the highest TR; these three cultivars demonstrated much higher resistance to C. chinensis than did the other cultivars. The cultivar Gold Nijisseiki, with a large C. chinensis population size, showed low PT and TR. The findings of this study may provide valuable information to pear growers, experts and scientists regarding plant protection, cultivation and breeding when selecting suitable varieties to culture from the perspective of pest control.

Early Enteral Nutrition and Sepsis-Associated Acute Kidney Injury: A Propensity Score Matched Cohort Study Based on the MIMIC-III Database

Jun Wang,Li Jiang,Sheng Ding,Si-Yi He,Shun-Bi Liu,Zhong-Jie Lu,Yuan-Zhang Liu,Li-Wen Hou,Bin-Su Wang,Jin-Bao Zhang 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.4

Purpose: We aimed to analyze the optimal timing of enteral nutrition (EN) in the treatment of sepsis and its effect on sepsis-asso ciated acute kidney injury (SA-AKI.)Materials and Methods: The MIMIC-III database was employed to identify patients with sepsis who had received EN. With AKI as the primary outcome variable, receiver operating characteristic (ROC) curves were utilized to calculate the optimal cut-off time of early EN (EEN). Propensity score matching (PSM) was employed to control confounding effects. Logistic regressions and propen sity score-based inverse probability of treatment weighting were utilized to assess the robustness of our findings. Comparisons within the EEN group were performed. Results: 2364 patients were included in our study. With 53 hours after intensive care units (ICU) admission as the cut-off time of EEN according to the ROC curve, 1212 patients were assigned to the EEN group and the other 1152 to the delayed EN group. The risk of SA-AKI was reduced in the EEN group (odds ratio 0.319, 95% confidence interval 0.245–0.413, p<0.001). The EEN patients re ceived fewer volumes (mL) of intravenous fluid (IVF) during their ICU stay (3750 mL vs. 5513.23 mL, p<0.001). The mediating ef fect of IVF was significant (p<0.001 for the average causal mediation effect). No significant differences were found within the EEN group (0–48 hours vs. 48–53 hours), except that patients initiating EN within 48 hours spent fewer days in ICU and hospital. Conclusion: EEN is associated with decreased risk of SA-AKI, and this beneficial effect may be proportionally mediated by IVF volume.

Association of Lipoprotein-Associated Phospholipase A_2 with Characteristics of Vulnerable Coronary Atherosclerotic Plaques

Yu-Sheng Liu,Qing-Hua Lu,Xiao-Bo Hu,Hong-Zhuan Li,Wei-Dong Jiang,Xin Wang,Hao Lin,Ai-Qiong Qin,Yong-Mei Wang,Tong Zhao,Zhao-Qiang Dong,Mei Zhang 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.6

Purpose: Lipoprotein-associated phospholipase A2 (Lp-PLA_2) is an inflammatory enzyme expressed in atherosclerotic plaques. We investigated the association of circulating Lp-PLA_2 with characteristics of vulnerable coronary atherosclerotic plaques. Materials and Methods: We recruited 113 patients with either unstable angina (UA, n=59) and stable angina (SA, n=54) by coronary angiography. Thirty-six healthy subjects served as controls. Intravascular ultrasound (IVUS) was used to evaluate the characteristics of coronary atherosclerotic plaque, and serum Lp-PLA2 concentration was measured as well. Results: Lp-PLA_2 concentration was significantly higher in both UA and SA patients [(396±36) μg/L and (321±39) μg/L, respectively]compared with the controls [(127±49) μg/L, p<0.01], and higher in UA than SA group. IVUS findings showed that remodeling index (RI) (0.91±0.15 vs. 0.85±0.11, p=0.005) and eccentricity index (EI) (0.73±0.16 vs. 0.65±0.22, p=0.039) were larger in UA than in SA group, and fibrous caps were thicker in SA than UA group [(0.91±0.23) mm vs. (0.63±0.21) mm, p=0.032]. Moreover, Lp-PLA_2 correlated positively with EI (r=0.439, p<0.01) and RI (r=0.592, p<0.05) in UA group. There was an inverse relationship between Lp-PLA_2 and fibrous cap thickness in both UA (r=-0.587, p<0.001) and SA (r=-0.318, p<0.05) groups. The independent risk factors in UA group were Lp-PLA_2 (OR=1.055, 95% CI: 1.03-1.08, p=0.013), LDL-cholesterol (OR=0.032, 95% CI: 0.00-0.05, p=0.041) and fibrous cap thickness (OR=0.008, 95% CI: 0.00-0.45, p=0.019). Lp-PLA_2 was strongly associated with both EI and fibrous cap thickness in both groups. Conclusion: Serum level of Lp-PLA_2 is associated with both eccentricity index and fibrous cap thickness in both UA and SA groups. Elevated levels of circulating Lp-PLA_2 might to be a strong risk factor and more serious for unstable angina than stable angina.