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      • Relation Extraction Using Convolution Tree Kernel Expanded with Entity Features

        ( Long Hua Qian ),( Guo Dong Zhou ),( Qiao Min Zhu ),( Pei De Qian ) 한국언어정보학회 2007 학술대회 논문집 Vol.2007 No.-

        This paper proposes a convolution tree kernel-based approach for relation extraction where the parse tree is expanded with entity features such as entity type, subtype, and mention level etc. Our study indicates that not only can our method effectively capture both syntactic structure and entity information of relation instances, but also can avoid the difficulty with tuning the parameters in composite kernels. We also demonstrate that predicate verb information can be used to further improve the performance, though its enhancement is limited. Evaluation on the ACE2004 benchmark corpus shows that our system slightly outperforms both the previous best-reported feature-based and kernel-based systems.

      • KCI등재

        A novel charring agent containing caged bicyclic phosphate and its application in intumescent flame retardant polypropylene systems

        Hua-Qiao Peng,Qian Zhou,De-Yi Wang,Li Chen,Yu-Zhong Wang 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.5

        A novel charring agent, bis(2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-oxo-4-hydroxymethyl) phenylphosphonate (BCPPO), was synthesized and characterized by FT-IR, 1H NMR and 31P NMR spectroscopies. Moreover, the novel charring agent combining with ammonium polyphosphate (APP) as well as melamine (MA) was adopted as intumescent flame retardants (IFR) to impart flame retardance and dripping resistance to polypropylene (PP). Flammability and thermal behaviors of the treated PP were investigated by Limiting Oxygen Index (LOI), Vertical Burning Test (UL-94), Thermogravimetric Analysis (TGA) and Cone Calorimeter test. Results indicate that the intumescent flame retardant with the novel charring agent shows both excellent flame retardance and anti-dripping abilities for PP when the three main components of IFR coexist at appropriate proportions, and the optimum flame retardant formulation is APP:MA:BCPPO = 3:1:1 that gives an LOI of 30.3 and UL- 94 V-0 rating, moreover, both the heat release rate (HRR) and the total heat release (THR) of IFR-PP with the optimum formulation decrease significantly relative to PP from cone calorimeter analysis. The residues from decomposition of the IFR-treated PP was characterized by FT-IR spectroscopy and SEM micrograph, and it was found that the char yield as well as char properties have direct effects on the flame retardance and anti-dripping behaviors of the treated PP.

      • Study on the Innovation Efficiency of China’s High - tech Industry Considering the Enterprise Nature

        Li Qian,Wen-ping Wang,Ren-qiao Xiao 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10

        This paper applies the DEA model to measure the innovation efficiency of the regional high-tech industry, domestic, Hong Kong, Macao and Taiwan and foreign-invested enterprises in China between 2008 and 2014 .The results show that: (i) from the whole, if the differences in enterprise nature is not considered, the average innovation efficiency of China"s high-tech industry is 0.748, and the pure technical efficiency and scale efficiency have some space to improve. The industry efficiencies in central and western provinces are low. (ii) The average efficiency of China"s domestic, Hong Kong, Macao and Taiwan and foreign-invested enterprises are 0.476, 0.529 and 0.525 respectively, which are lower than traditional DEA efficiency significantly, the efficiency of domestic enterprises was the lowest, and it showed a slight increase during the examination period. There are some differences in the root causes of efficiency loss in each province. For example, domestic enterprises’ innovation efficiency in Beijing is low, et al.

      • KCI등재

        Carnosic Acid Protects Biomolecules from Free Radical-mediated Oxidative Damage In vitro

        Qisen Xiang,Qian Liu,Li Xu,Yan Qiao,Yutang Wang,Xuebo Liu 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5

        The protective effects of carnosic acid (CA), a naturally occurring catechol-type poly-phenolic diterpene,against free radical-induced oxidative damage to lipids,proteins, and DNA were evaluated in this study. The oxidation of human serum albumin and rat liver homogenate were induced by Cu2+/H2O2. Fe2+/VitC and 2,2'-azobis(2,4-dimethylvaleronitrile) were used to initiate linoleic acid (LA) peroxidation. Oxidative damage of DNA was carried out using 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The results showed that CA significantly inhibited the oxidative damages to proteins, LA and DNA caused by various types of free radicals. Moreover, in the Fe2+/VitC induced-LA peroxidation reaction system, the addition of CA also inhibited the cytotoxic effects of oxidized linoleic acid on RAW 264.7 cells. These results suggest that it might be possible to use CA to prevent or treat the oxidative stress-related disorders and diseases.

      • KCI등재

        Protective Effects of the Ethanol Extract of Viola tianshanica Maxim against Acute Lung Injury Induced by Lipopolysaccharides in Mice

        ( Xue Wang ),( Qiao-li Yang ),( Yu-zhu Shi ),( Bi-yu Hou ),( Sheng-qian Yang ),( Hua Huang ),( Li Zhang ),( Guan-hua Du ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.9

        Viola tianshanica Maxim, belonging to the Violaceae plant family, is traditionally used in Uighur medicine for treating pneumonia, headache, and fever. There is, however, a lack of basic understanding of its pharmacological activities. This study was designed to observe the effects of the ethanol extract (TSM) from Viola tianshanica Maxim on the inflammation response in acute lung injury (ALI) induced by LPS and the possible underlying mechanisms. We found that TSM (200 and 500 mg/kg) significantly decreased inflammatory cytokine production and the number of inflammatory cells, including macrophages and neutrophils, in bronchoalveolar lavage fluid. TSM also markedly inhibited the lung wet-to-dry ratio and alleviated pathological changes in lung tissues. In vitro, after TSM (12.5-100 μg/ml) treatment to RAW 264.7 cells for 1 h, LPS (1 μg/ml) was added and the cells were further incubated for 24 h. TSM dose-dependently inhibited the levels of proinflammatory cytokines, such as NO, PGE<sub>2</sub>, TNF-α, IL-6, and IL-1β, and remarkably decreased the protein and mRNA expression of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells. TSM also suppressed protein expression of p-IκBa and p-ERK1/2 and blocked nuclear translocation of NF-κB p65. The results indicate that TSM exerts anti-inflammatory effects related with inhibition on NF-κB and MAPK (p-ERK1/2) signaling pathways. In conclusion, our data demonstrate that TSM might be a potential agent for the treatment of ALI.

      • VHL Gene Mutation Analysis of a Chinese Family with Non-Syndromic Pheochromocytomas and Patients with Apparently Sporadic Pheochromocytoma

        Zhang, Bin,Qian, Jing,Chang, De-Hui,Wang, Yang-Min,Zhou, Da-Hai,Qiao, Gou-Mei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Objective: The Von Hippel-Lindau syndrome (VHLD), an inherited neoplastic syndrome predisposing to central nervous system hemangioblastoma (CNS), pheochromocytoma (PCC), renal cell carcinoma(RCC), retinal hemangioma (RA) and renal cysts, is caused by mutations or deletions of the VHL tumor-suppressor gene. To assess VHL genotype-phenotype correlations with function of pVHL a gene mutation analysis of members in a Chinese family with non-syndromic PCCs and individuals with apparently sporadic pheochromocytoma (ASP) was performed. Materials and Methods: DNA samples of 20 members from the Chinese family with non-syndromic PCCs and 41 patients with ASP were analyzed by polymerase chain reaction and direct sequencing, confirmed by Taqman probe. Results: Three novel mutations (H125P, 623(^TTTGTtG) and R120T) were identified in the Chinese family and in 3 among 41 ASP patients. The mutations were all located in exon 2 of VHL gene encoding ${\beta}$-domain of pVHL. The tumor type in H125P carriers and R120T carriers was VHL type 2C. And 623(^TTTGTtG) carriers presented VHL type 2B or type 2C. Conclusions: VHL gene abnormalities were identified in the Chinese family with non-syndromic PCCs and patients with APS, resulting in dysfunction of pVHL. H125P and R120T could be associated with VHL type 2C, while 623(^TTTGTtG) might be linked with VHL type 2B or type 2C. Not only is the genetic analysis helpful for early diagnosis and treatment of patients with VHLD, it is also benefitial for research intoVHLD pathogenesis.

      • SCIESCOPUS

        Deep auto-context convolutional neural networks for standard-dose PET image estimation from low-dose PET/MRI

        Xiang, Lei,Qiao, Yu,Nie, Dong,An, Le,Lin, Weili,Wang, Qian,Shen, Dinggang Elsevier 2017 Neurocomputing Vol.267 No.-

        <P><B>Abstract</B></P> <P>Positron emission tomography (PET) is an essential technique in many clinical applications such as tumor detection and brain disorder diagnosis. In order to obtain high-quality PET images, a standard-dose radioactive tracer is needed, which inevitably causes the risk of radiation exposure damage. For reducing the patient's exposure to radiation and maintaining the high quality of PET images, in this paper, we propose a deep learning architecture to estimate the high-quality standard-dose PET (SPET) image from the combination of the low-quality low-dose PET (LPET) image and the accompanying T1-weighted acquisition from magnetic resonance imaging (MRI). Specifically, we adapt the convolutional neural network (CNN) to account for the two channel inputs of LPET and T1, and directly learn the end-to-end mapping between the inputs and the SPET output. Then, we integrate multiple CNN modules following the auto-context strategy, such that the tentatively estimated SPET of an early CNN can be iteratively refined by subsequent CNNs. Validations on real human brain PET/MRI data show that our proposed method can provide competitive estimation quality of the PET images, compared to the state-of-the-art methods. Meanwhile, our method is highly efficient to test on a new subject, e.g., spending ∼2 s for estimating an entire SPET image in contrast to ∼16 min by the state-of-the-art method. The results above demonstrate the potential of our method in real clinical applications.</P>

      • KCI등재

        Fault-tolerant Control for Linear System Under Sensor Saturation Constraint

        Jun-Wei Zhu,Qiao-Qian Zhou,Jianming Xu,Jian-Wei Dong 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

        An observer-based fault-tolerant control method is proposed for a linear system with sensor saturationconstraint. Considering the linear system with simultaneous actuator faults and sensor faults, the sensor saturation would bring the output measurement error of the system, which would result in the estimation performancedegradation. Firstly, the intermediate estimator is modified to estimate the system states and fault signals at thesimultaneous time, and the fault-tolerant controller is designed based on the estimation to compensate the effectof actuator faults effectively. Through Lyapunov stability analysis, the sufficient conditions are obtained to ensurethe states of closed-loop system to be uniformly ultimately bounded. The effect of sensor saturation error can besuppressed by adjusting some specified parameters directly without introducing any performance index. Finally, theeffectiveness and superiority of the proposed method are verified by a simulation example

      • KCI등재

        Manganese-based spinel adsorbents for lithium recovery from aqueous solutions by electrochemical technique

        Honglong Zhan,Yingjun Qiao,Zhiqiang Qian,Jun Li,Zhijian Wu,Xiaogang Hao,Zhong Liu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

        The manganese-based spinel adsorbent (HMO) refers to lithium-ion adsorbents derived from the spinellithium manganese oxide (LMO). Two types of lithium ions extraction composite films composed of HMO(HMn2O4 and H1.6Mn1.6O4) are successfully prepared by the blade coating method. Based on the excellentLi+ selectivity of HMO and the outstanding conductivity of conductive carbon black (C), HMO/C films arecarried out to extract lithium by electrochemically switched ion exchange (ESIX) technique. HMO has acertain adsorption capacity for Li+ when the Li+ concentration is close to the actual brine, and the adsorptioncapacity of HMn2O4 and H1.6Mn1.6O4 is 24.56 mg/g and 34.40 mg/g, respectively. HMO showed goodselectivity for Li+ in multiple metal ions solution. The capacity of HMn2O4 and H1.6Mn1.6O4 keep 80% and86% of the initial values after 5 cycles, respectively. The inherent different lithium occupied leads to thedifference of electrical-adsorption abilities between HMn2O4 and H1.6Mn1.6O4. H1.6Mn1.6O4 has a broadapplication prospect in lithium extraction from salt lake brine due to its lower application voltage, largeadsorption capacity and superior stability.

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