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Kim, Han Geun,Gim, Min Geun,Kim, Joo Yun,Jin Hwang, Hyun,Ham, Min Seok,Lee, Jung Min,Hartung, Thomas,Park, Jung Woo,Han, Seung Hyun,Chung, Dae Kyun Oxford University Press 2007 FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY Vol.49 No.2
<P>In this study, the stimulatory effects of different lactic acid bacteria strains, and their subcellular fractions, on the THP-1 cell line were evaluated. Lactobacillus plantarum was found in particular to induce high levels of IL-23p19 mRNA, but it moderately induced TNF-alpha production. IL-10 production was not entirely affected by L. plantarum stimulation. When subcellular fractions of L. plantarum were used to treat THP-1 cells, IL-23p19 mRNA expression was enhanced in a dose-responsive manner, specifically by lipoteichoic acid (LTA). The cotreatment of THP-1 cells by both L. plantarum and Staphylococcus aureus LTA resulted in decreased IL-10 production when compared with cells treated by S. aureus LTA alone. Taken together, these data suggest that LTA isolated from L. plantarum elicits stimulatory effects upon the expression of IL-23p19 and inhibitory effects on pathogen-mediated IL-10 production.</P>