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- 저자 : ( Mesut Akyol ) (검색결과 2 건)
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Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
Ozcabi, Bahar,Demirhan, Salih,Akyol, Mesut,Akay, Hatice Ozturkmen,Guven, Ayla The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.12
Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6-18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients' medical records. LAP was calculated as [waist circumference (WC) (cm) - 58]×triglycerides (mmol/L) in girls; [WC (cm) - 65]×triglycerides (mmol/L) in boys. The minLAP and adjLAP were described (3% and 50% of WC values, respectively) and the total/high-density lipoprotein cholesterol index (TC/HDL-C) was calculated. NAFLD was observed on ultrasound, and patients were divided into 3 groups by steatosis grade (normal, grade 0; mild, grade 1; moderate-severe, grade 2-3). The area under the curve (AUC) and appropriate index cutoff points were calculated by receiver operator characteristic analysis. Results: LAP was positively correlated with puberty stage (rho=0.409; P<0.001), fasting insulin (rho= 0.507; P<0.001), homeostasis model assessment of insulin resistance (rho=0.470; P<0.001), uric acid (rho=0.522; P<0.001), and TC/HDL-C (rho=0.494; P<0.001) and negatively correlated with HDL-C (rho=-3.833; P<0.001). LAP values could be used to diagnose hepatosteatosis (AUC=0.698; P=0.002). The LAP, adjLAP, and minLAP cutoff values were 42.7 (P=0.002), 40.05 (P=0.003), and 53.47 (P= 0.08), respectively. For LAP, the differences between the normal and mild groups (P=0.035) and the normal and moderate-severe groups were statistically significant (P=0.037), whereas the difference between the mild and moderate-severe groups was not (P>0.005). There was a statistically significant difference between the normal and mild groups for adjLAP (P=0.043) but not between the other groups (P>0.005). There was no significant intergroup difference in minLAP (P>0.005). Conclusion: LAP is a powerful and easy tool to predict NAFLD in childhood. If LAP is ≥42.7, NAFLD should be suspected. This is the first study to assess LAP diagnostic accuracy for childhood obesity.
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( E Sacide Kozan ),( Salih Kozan ),( Yalcin Aral ),( Ahmet Yildirim ),( Mesut Akyol ),( Zafer Aydin Ecemis ),( Necat Imirzalioglu ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Graves` disease is more prevalent in women. HLA-DR locus, an immune response genes, is well-studied in different populations, but the difference in distributions of succestibility alleles between females and males are required to be clarifi ed. Methods: Totally 140 subjects consisting of 70 patients with Graves` disease (GD) (44 females, 26 males) and 70 controls (55 females, 15 males) were included to the study. Thirteen polymorphisms for DRB1 with DRB3, DRB4 and DRB5 were analysed by PCRSSP method. The difference in distributions of DR alleles were compared between females and males. A study model was designed for confi rming of Results: Results: None of DR polimorphisms, in existance or absence of alleles, was associated with GD among males. However, in absence of DRB1*07, GD risk was higher than the carriage of at least one allele in females (p=0.012, OR=9.56). In addition, the development of GD risk among females was higher in the carriage of at least one DRB1*15 allele (p=0.004, OR=4.67). Carriage of DRB5 was also found in association with GD among females with suggestive risk (p=0.003, OR=4.07). However, underlying cause of the risk was unclear due to the haplotype inheritance of DRB1*15/ DRB5. Conclusions: We concluded that, gender is an effective factor on the evaluation of the association between DR polymorphisms and GD.
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