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( E Sacide Kozan ),( Salih Kozan ),( Yalcin Aral ),( Ahmet Yildirim ),( Mesut Akyol ),( Zafer Aydin Ecemis ),( Necat Imirzalioglu ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Graves` disease is more prevalent in women. HLA-DR locus, an immune response genes, is well-studied in different populations, but the difference in distributions of succestibility alleles between females and males are required to be clarifi ed. Methods: Totally 140 subjects consisting of 70 patients with Graves` disease (GD) (44 females, 26 males) and 70 controls (55 females, 15 males) were included to the study. Thirteen polymorphisms for DRB1 with DRB3, DRB4 and DRB5 were analysed by PCRSSP method. The difference in distributions of DR alleles were compared between females and males. A study model was designed for confi rming of Results: Results: None of DR polimorphisms, in existance or absence of alleles, was associated with GD among males. However, in absence of DRB1*07, GD risk was higher than the carriage of at least one allele in females (p=0.012, OR=9.56). In addition, the development of GD risk among females was higher in the carriage of at least one DRB1*15 allele (p=0.004, OR=4.67). Carriage of DRB5 was also found in association with GD among females with suggestive risk (p=0.003, OR=4.07). However, underlying cause of the risk was unclear due to the haplotype inheritance of DRB1*15/ DRB5. Conclusions: We concluded that, gender is an effective factor on the evaluation of the association between DR polymorphisms and GD.