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- 저자 : ( Kristina Lama ) (검색결과 3 건)
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Kristina LAMA,Taeijn PARK,Seung-Young KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4
Due to the depletion and loss of natural products, various types of materials are being developed. Accordingly, studies using callus using plant tissue culture technology are being conducted. Callus refers to the unorganized flow cell mass of plants. Callus cells usually develop in the wound area of a living plant and protect the wound. For biological research and bioengineering research, pure callus can be induced by sterilizing a part of plant tissue and transferring it to a tissue culture medium. In this study, Biorenovation was used for callus. Biorenovation is a method of modifying the structure of a broad range of substrates such as chemical compounds and plant extract by microbial enzymes with the potential benefits of reduced cytotoxicities and enhanced biological activities relative to its parent substrates. We applied this method to Lysimachia quelpaertensis (LQ) callus to obtain Lysimachia quelpaertensis Biorenovated extracts (LQBR), and compared the whitening activity efficacy of LQ and LQBR. As a result, experiments were conducted at concentrations (12.5, 25, 50 µg/mL) without cytotoxicity in B16F10 melanoma cells treated with stimulants. In addition, as a result of comparing the inhibitory effect of melanin production and tyrosinase activity, a large whitening activity was confirmed in LQBR. And by measuring the expression levels of enzymes and proteins involved in melanin formation, it was demonstrated that LQBR induces more inhibition of protein expression than LQ. These results reveal new possibilities for limited cosmetic materials.
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( Kristina Lama ),( Hyehyun Hong ),( Tae-jin Park ),( Jin-soo Park ),( Won-jae Chi ),( Seung-young Kim ) 한국응용생명화학회 2023 Journal of Applied Biological Chemistry (J. Appl. Vol.66 No.-
Recent studies have highlighted the link between diseases and inflammation across our lifespan. Our sedentary lifestyle, high-calorie diet, chronic stress, chronic infections, and exposure to pollutants and xenobiotics, collectively intensify the course and recurrence of infections and inflammation in our bodies, promoting the prevalence of chronic diseases and aging. Given such phenomena and considering additional factors such as the frequency of prescription, and easy access to over-the-counter drugs, the need for anti-inflammatory therapeutics is ever-increasing. However, the readily available anti-inflammatory treatment option comes with a greater risk of side effects or high cost (biologics). Therefore in this growing competition of discovering and developing new potent anti-inflammatory drugs, we focused on utilizing the established knowledge of traditional medicine to find lead compounds. Since lead optimization is an indispensable step toward drug development, we applied this concept for the production of potent anti-inflammatory compounds achieved by structural modification of flavonoids. The derivative obtained through acetylation of myricetin, 3,3',4',5,5',7-hexaacetate myricetin, showed a greater inhibitory effect in the production of pro-inflammatory mediators such as nitric oxide, Prostaglandin E2, and pro-inflammatory cytokines like interleukin-6, interleukin- 1β, in lipopolysaccharide-stimulated RAW264.7 mouse macrophage cells compared to myricetin. The increased potency of inhibition was in conjunction with an increased inhibitory effect on inducible nitric oxide synthase and cyclooxygenase-2 proteins. Through such measures, this study supports lead optimization for well-established lead compounds from traditional medicine using a simpler and greener chemistry approach for the purpose of designing and developing potent anti-inflammatory therapeutics with possibly fewer side effects and increased bioavailability.
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