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Kensuke Takenkaka,Akihito Jinnai,Kentaro Kotani,Satoshi Suzuki,Takafumi Asao,Asuka Otsuka,Seiji Nakagawa 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
The objective of this study was to evaluate the influence of the intensity of perceived tactile stimuli on the difference of the spatial location on the palm. Air-puff stimuli were presented on 16 different locations on the palm as well as the tip of the index finger. Participants performed magnitude estimation protocol, where each tactile stimulus was evaluated in terms of the stimulus intensity. The results revealed that the relationship of perceived tactile intensity between distal and proximal sides showed no significant difference, whereas the relationship between medial and lateral sides showed significant differences in perceived stimulus. Difference of perceived intensity between medial and lateral sides implied that hardness of the skin surface may affect the perceived intensity rather than the distribution of mechanoreceptors on the palm. Overall, current results obtained in this study would contribute to the optimum design specifications for tactile interface devices.
( Kensuke Takenkaka ),( Akihito Jinnai ),( Kentaro Kotani ),( Satoshi Suzuki ),( Takafumi Asao ),( Asuka Otsuka ),( Seiji Nakagawa ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
The objective of this study was to evaluate the influence of the intensity of perceived tactile stimuli on the difference of the spatial location on the palm. Air-puff stimuli were presented on 16 different locations on the palm as well as the tip of the index finger. Participants performed magnitude estimation protocol, where each tactile stimulus was evaluated in terms of the stimulus intensity. The results revealed that the relationship of perceived tactile intensity between distal and proximal sides showed no significant difference, whereas the relationship between medial and lateral sides showed significant differences in perceived stimulus. Difference of perceived intensity between medial and lateral sides implied that hardness of the skin surface may affect the perceived intensity rather than the distribution of mechanoreceptors on the palm. Overall, current results obtained in this study would contribute to the optimum design specifications for tactile interface devices.
Life Science : Ascochlorin activates p53 in a manner distinct from DNA damaging agents
( Ji Hak Jeong ),( Hiroo Nakajima ),( Junji Magae ),( Chiharu Furukawa ),( Keiko Taki ),( Kensuke Otsuka ),( Masanori Tomita ),( In Seon Lee ),( Cheorl Ho Kim ),( Hyeun Wook Chang ),( Kwan Sik Min ),( 영남대학교 약품개발연구소 2009 영남대학교 약품개발연구소 연구업적집 Vol.19 No.-
Ascochlorin activates p53 in a manner distinct from DNA damaging agents
Jeong, Ji-Hak,Nakajima, Hiroo,Magae, Junji,Furukawa, Chiharu,Taki, Keiko,Otsuka, Kensuke,Tomita, Masanori,Lee, In-Seon,Kim, Cheorl-Ho,Chang, Hyeun-Wook,Min, Kwan-Sik,Park, Kwang-Kyun,Park, Kwan-Kyu,Ch Wiley Subscription Services, Inc., A Wiley Company 2009 International journal of cancer: Journal internati Vol.124 No.12
<P>Ascochlorin, a prenylphenol antitumor antibiotic, profoundly increases the expression of endogenous p53 by increasing protein stability in the human osteosarcoma cells and human colon cancer cells. Ascochlorin also increases DNA binding activity to the p53 consensus sequence in nuclear extract and enhances transcription of p53 downstream targets. Ascochlorin specifically induces p53 phosphorylation at ser 392 without affecting ser 15 or 20, whereas DNA damaging agents typically phosphorylate these serines. Moreover, ascochlorin does not induce phosphorylation of ATM and CHK1, an established substrate of ATR that is activated by genotoxins, nor does it increase DNA strand break, as confirmed by comet assay. The structure-activity relationship suggests that p53 activation by ascochlorin is related to inhibition of mitochondrial respiration, which is further supported by the observation that respiratory inhibitors activate p53 in a manner similar to ascochlorin. These results suggest that ascochlorin, through the inhibition of mitochondrial respiration, activates p53 through a mechanism distinct from genotoxins. © 2009 UICC</P>