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      • Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions

        Nguyen, Huynh Quoc,Zada, Sahib,Lai, Trang Huyen,Pham, Trang Minh,Hwang, Jin Seok,Ahmed, Mahmoud,Kim, Deok Ryong Elsevier 2019 Neuroscience Letters Vol.701 No.-

        <P><B>Abstract</B></P> <P>Oxidative damage in neurons including glutamate excitotoxicity has been linked to increasing numbers of neuropathological conditions. Under these conditions, cells trigger several different cellular responses such as autophagy, apoptosis, necrosis and senescence. However, the connection between these responses is not well understood. In this study, we found that the 60-kDa BECN1 was specifically degraded to a 40-kDa fragment in hippocampal HT22 cells treated with 5 mM glutamate. Increased BECN1 cleavage was specifically associated with a decrease in cell viability under oxidative stress. Interestingly, this BECN1 cleavage was specifically inhibited by a calpain inhibitor ALLN but was not affected by other protease inhibitors. Also, the BECN1 cleavage was not detected in calpain-4-deficient cell lines. Furthermore, calpain cleaved BECN1 at a specific site between the coiled-coil domain and Bcl2 homology 3 domain, which is associated with the anti-apoptotic protein Bcl-2. Moreover, some cellular senescence markers, including β-galactosidase, p21, p27<SUP>Kip1</SUP>, p53 and p16<SUP>INK4A</SUP>, increased proportionally to those of BECN1 cleaved fragments. These results suggest that calpain-mediated BECN1 cleavage under oxidative conditions is specifically associated with cell death induced by cellular senescence.</P> <P><B>Highlights</B></P> <P> <UL> <LI> BECN1 was specifically degraded to a 40-kDa fragment accompanying with decrease of cell viability under oxidative stress. </LI> <LI> BECN1 cleavage was inhibited by calpain inhibitor but not by other protease inhibitors. </LI> <LI> Calpain cleaves BECN1 at a specific site between CCD and BH3 domains. </LI> <LI> BECN1 degradation stimulates senescence-associated cell death at the oxidative stress. </LI> </UL> </P>

      • Nonlinear Optimal Control of a 3-D Overhead Crane with Varying Rope Length

        Huynh Phi Long Nguyen,Quoc Chi Nguyen 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10

        In this paper, a nonlinear optimal control of a 3-D overhead crane is investigated, where time varying rope length is considered in the control design. The Euler-Lagrange equations is employed to derive the dynamic model of the overhead crane. The proposed optimal control law guarantees the minimum of the sway angles together with the control efforts. The numerical simulations and experiments are carried out to verify the effectiveness of the proposed control method, where the con-sistency between numerical simulation and experiment results are shown.

      • KCI등재

        Synthesis of a Novel Fluorescent Cyanide Chemosensor Based on Photoswitching Poly(pyrene-1-ylmethyl-methacrylate-randommethyl methacrylate-random-methacrylate spirooxazine)

        Hoan Minh Tran,Tam Huu Nguyen,Viet Quoc Nguyen,Phuc Huynh Tran,Linh Duy Thai,Thuy Thu Truong,Le-Thu T. Nguyen,Ha Tran Nguyen 한국고분자학회 2019 Macromolecular Research Vol.27 No.1

        The photoswitching poly(pyrene-1-ylmethyl-methacrylate-random-methyl methacrylate-random-methacrylate spirooxazine) was synthesized via atom transfer radical polymerization and characterized by proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), Fourier transform infrared (FTIR) spectroscopy, UV-visible spectroscopy, and differential scanning calorimetry (DSC). The obtained copolymer exhibited the capability of erasable and rewritable photoimaging, making it a potential candidate for optical data storage materials. Moreover, the copolymer also showed the sensing ability for cyanide anions effect in aqueous solutions.

      • SCOPUS

        How Destination Image Factors Affect Domestic Tourists Revisit Intention to Ba Ria-Vung Tau Province, Vietnam

        GIAO, Ha Nam Khanh,NGAN, Nguyen Thi Kim,PHUC, Nguyen Pham Hanh,TUAN, Huynh Quoc,HONG, Ha Kim,ANH, Huynh Diep Tram,NHU, Duong Thi Huynh,LAN, NgoThi Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.6

        This research examines the affect of destination image factors on revisit intention of domestic tourists at Ba Ria Vung-Tau (BRVT), by questioning directly 510 domestic tourists. The convenient sampling method is used in dividing the crowds into four groups; the four main surveyed areas in BRVT are: Vung Tau, Long Hai-Phuoc Hai, Xuyen Moc and Con Dao. A combination of qualitative and quantitative methodologies were utilized.A focus group of 10 domestic tourists wasset up to review and explore the variousfactors as well as the conceptual model. An in-depth interview with 12 participants was developed to fine-tune measurement items. The questionnaire applied a 5-point Likert scale. Checking the reliability by Cronbach's Alpha, exploratory factor analyzing and linear multiple regression were used with the SPSS program. The results show that there are eight main destination image factors affecting domestic tourists revisit intention to BRVT using linear regression and arranged by decreasing importance: Infrastructure, Variety Seeking, Accessibility, Local food, Atmosphere, Environment, Price Value, Leisure and Entertainment. From that, the research offers some suggestions and policy recommendations for the tourism business and provincial policy-makers to identify the main issues and develop better customer services to increase domestic tourists'revisit intention.

      • SCOPUS

        Impact of Corporate Social Responsibility on Repurchase Intention: A Case Study in the FMCG Industry in Vietnam

        Minh Sang VO(Minh Sang VO ),Minh Quoc PHAM(Minh Quoc PHAM ),Thuy Bao Thu LE(Thuy Bao Thu LE ),Le Kim Ngan NGUYEN(Le Kim Ngan NGUYEN ),Xuan Tung DAO(Xuan Tung DAO ),Huynh To Nhi PHAM(Huynh To Nhi PHAM 한국유통과학회 2023 The Journal of Asian Finance, Economics and Busine Vol.10 No.2

        The study aims to evaluate the impact of corporate social responsibility on customers’ repurchase intention in Vietnam’s fast-moving consumer goods (FMCG) industry. This study employs primary data surveyed from 417 Vietnamese consumers, and the sample is selected based on the willingness to participate in providing information. The results show corporate social responsibility’s positive impact on repurchase intention in the FMCG industry in the Vietnam market. There are three components of corporate social responsibility, including ethical responsibility, legal responsibility, and economic responsibility have a positive impact on repurchase intention. The economic responsibility component has the greatest effect on repurchase intention. There is not enough statistical basis for the philanthropic responsibility component of corporate social responsibility to recognize its impact on repurchase intention. The findings of this study suggest that companies dealing in the FMCG industry in Vietnam need to invest more in further developing their corporate social responsibility, it not only helps to improve their customer loyalty to businesses but also contributes to promoting the country’s economic and social development in a better and more sustainable direction.

      • KCI등재

        Application of Internet of Things Based Monitoring System for indoor Ganoderma Lucidum Cultivation

        Quoc Cuong Nguyen,Hoang Tan Huynh,Tuong So Dao,HyukDong Kwon The Institute of Internet 2023 International journal of advanced smart convergenc Vol.12 No.2

        Most agriculture plantings are based on traditional farming and demand a lot of human work processes. In order to improve the efficiency as well as the productivity of their farms, modern agricultural technology was proven to be better than traditional practices. Internet of Things (IoT) is usually related in modern agriculture which provides the farmer with a real-time monitoring condition of their farm from anywhere and anytime. Therefore, the application of IoT with a sensor to measure and monitors the humidity and the temperature in the mushroom farm that can overcome this problem. This paper proposes an IoT based monitoring system forindoor Ganoderma lucidum cultivation at a minimal cost in terms of hardware resources and practicality. The results show that the data of temperature and humidity are changing depending on the weather and the preliminary experimental results demonstrated that all parameters of the system were optimized and successful to achieve the objective. In addition, the analysis results show that the quality of Ganoderma lucidum produced on the research method conforms to regulations in Vietnam.

      • KCI등재

        The Effect of Employees’ Job Satisfaction on Customer Satisfaction and Loyalty: An Empirical Study in Vietnam

        Quoc Nghi NGUYEN,Van Ba HUYNH,Van Nam MAI,Thi Hong Loc HOANG 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12

        In the context of economic integration and fierce competition, organizations are very concerned about customer orientation so as to build close relationships and ensure customer satisfaction and improve customer loyalty. In company strategy, customer relationship orientation is critical. Customer satisfaction and loyalty will improve if employees perform well in the customer-oriented process. The study’s purpose is to examine the links between doctors’ job happiness, customer orientation, customer satisfaction, and customer loyalty in international hospitals in Vietnam. In international hospitals, data was collected from 204 clinicians and 408 patients. By applying structural equation modeling. The study found that doctors’ job satisfaction had a significant impact on customer orientation and satisfaction in international hospitals. Customer satisfaction may be improved with a good customer orientation. The doctors’ job satisfaction and effective customer orientation improve customer satisfaction and loyalty towards international hospitals in Vietnam, thanks to the impact of spreading emotions. In particular, if doctors are satisfied with their jobs, it promotes customer satisfaction when using medical services at international hospitals. The study has proved the essential role of customer-oriented strategy and doctors’ job satisfaction in customer satisfaction and loyalty towards international hospitals.

      • SCISCIESCOPUS

        Prediction-based energy policy for mobile virtual desktop infrastructure in a cloud environment

        Nguyen, T.D.,Hung, P.P.,Dai, T.H.,Quoc, N.H.,Huynh, C.T.,Huh, E.N. Elsevier science 2015 Information sciences Vol.319 No.-

        Using cloud services from mobile devices has become a growing trend because of its mobility and convenience. However, mobile devices join and leave cloud services more frequently than traditional computers, which causes energy inefficiency in a cloud data center. Waste, in the form of energy and cooling requirements, particularly occurs when a mobile device disconnects from a service, but the cloud servers, known as virtual machines (VMs), continue running. The VMs should transition to lower-power states instead remaining active. However, transition to a lower-power state causes a service delay when users reconnect to the service because VMs in a lower-power state are not ready to serve. Therefore, an efficient energy policy must not only maximize energy savings but also minimize service delays. In this paper, we propose two approaches to energy efficiency: an Instant Energy Policy (IEP) that can quickly find an appropriate low-power state based on a predicted disconnection time and a Prediction-based Energy Policy (PrEP) that determines when to transition VMs to a low-power state and when to return them to the active state based on each users activity history. IEP predicts the unknown disconnection time using the multisize sliding windows workload estimation technique, which supports a non-stationary environment. This method can quickly obtain an energy policy, but it is limited when disconnection time fluctuates widely. PrEP presents an improved approach to achieve an optimal global result with respect to both energy consumption and service delay. Through simulations with a real-world dataset collected by the MIT Human Dynamics Lab, we show that PrEP provides approximately 20% power saving over the benchmark policies while guaranteeing minimal service delay.

      • KCI등재

        The Effect of Institutions on Productivity Spillovers from FDI to Domestic Firms: Evidence in Vietnam

        Huynh Quoc Vu,Pham Thi Bich Ngoc,Nguyen Le Hoang Thuy To Quyen 사람과세계경영학회 2022 Global Business and Finance Review Vol.27 No.3

        Purpose: The purpose of this study is to investigate the impact of formal institutions and their components on productivity spillovers from FDI enterprises to domestic firms’ TFP in developing countries like Vietnam. Design/methodology/approach: The study, conducted in two steps to explore the relationship, is to estimate the firm's TFP in accordance with the semi-parametric method of Levisohn and Petrin (2003). Regression is in accordance with the equation with panel data and adjusted by Driscoll and Kraay standard errors. An unbalanced panel data, related to more than 61,600 Vietnamese manufacturing firms from 2012 to 2017, is combined with the Provincial Institutional Quality Survey (PAPI index) and IO table. Findings: The local institutions have a positive impact on promoting learning ability and increasing productivity of domestic firms, especially small and medium enterprises (SMEs) that take better advantage of this effect. Vertical linkages with FDI enterprises assist local firms to increase productivity while horizontal linkages bring in negative effects. Domestic enterprises with high productivity (in the top 25%) receive positive spillover effects from horizontal linkages and vertical linkages and gain positive impacts of the institution on productivity whereas the group of low-productivity enterprises records negative impacts. This research highlights those enterprises operating in the region where institutions have transparency, accountability, participation in comments and effective corruption control can absorb spillovers and improve their productivity as well as the transparency and corruption control are recognized as having a positive impact through horizontal linkages. Research limitations/implications: With the limitation of research data being conducted only on manufacturing enterprises, there is a lack of data on the impact of service enterprises. The study only stops at understanding the impact of formal institutional effects on productivity spillovers whereas informal institutional effects will be studied in the future. Furthermore, the productivity spillovers of FDI enterprises are explored in general besides other FDI forms that will have different productivity spillovers like offshore. From the results of this study, the governments of developing countries should improve their institutions to encourage local enterprises to take the advantage of spillover effects from FDI enterprises as well as pay more attention to regional factors by supplementing development priority policies based on the capacity of each region. Institutional quality at provincial level has a positive impact on productivity spillovers; consequently, it is essential to have policies for further institutional improvement. Originality/value: This is the first research paper on the impact of the institutional factor at provincial level on firm’s productivity in developing countries like Vietnam. Theoretically, the impact of formal institutions on spillover effects from FDI enterprises is also clarified. In addition, our findings have implications for local economic development policies: vertical linkages promote domestic firms to increase their productivity while horizontal linkages of FDI enterprises in the same industry generate adverse impacts. This paper suggests some feasible solutions for SMEs in developing countries towards their productivity improvement.

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