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Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats
( Huayong Chen ),( Dandan Ma ),( Huapeng Zhang ),( Yanhong Tang ),( Jun Wang ),( Renhu Li ),( Wen Wen ),( Yi Zhang ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.1
Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in male rats. Methods: Four loose ligatures were placed around the sciatic nerve to induce CCI, and vincristine (50 μg/kg) was injected for 10 days to develop neuropathic pain. The development of cold allodynia, mechanical allodynia, and mechanical hyperalgesia was assessed using different pain-related behavioral tests. The levels of H<sub>2</sub>S, cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), orexin, and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured in the sciatic nerve. Results: Treatment with oleuropein for 14 days led to significant amelioration of behavioral manifestations of neuropathic pain in two pain models. Moreover, oleuropein restored both CCI and vincristine-induced decreases in H<sub>2</sub>S, CSE, CBS, orexin, and Nrf2 levels. Co-administration of suvorexant, an orexin receptor antagonist, significantly counteracted the pain-attenuating actions of oleuropein and Nrf2 levels without modulating H<sub>2</sub>S, CSE and CBS. Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H<sub>2</sub>S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.
Feasibility of Tissue Engineering Small Vessel Scaffold on Vascular Transplantation
( Chen Huayong ),( Bai Shuling ),( Chen Yingqing ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6
The glycoprotein with α-galactosyl-terminal is a major xenogeneic antigen for hyperacute rejection. In this study, we observed distributive features of α-galactosyl in endothelial and smooth muscle cells for small tissue engineering vessel scaffolds, and for vessels of Wistar rats and Japanese white rabbits. We also aimed to discuss the feasibility of small vessel scaffolds on xenotransplantation. We utilized 30 Wistar rat caudal arteries, non gender specific. Fifteen of caudal arteries were prepared for small acellular vessel scaffolds assigned as small vessel scaffold group, the other 15 caudal arteries were assigned as caudal artery group. We also collected eight Japanese white rabbits, non gender specific, and extracted 15 ear central arteries assigned as central artery group. We added Bandeireae Simplicifolia 1 Isolectin B4 (16 mg/L) to tissue sections for DAB staining, then we detected the positive reaction product of α-galactosyl. The expression of α-galactosyl in central artery group was mainly in membrane and nucleus of endothelial; in caudal artery group, which expressed strong positive in membrane of endothelial. However, in the vessel scaffold group, α-galactosyl expressed weakly or scarcely in the intima of the vessels. The absorbency of caudal artery group was significantly higher than that of central vessel group, and which of vessel scaffold group was significantly lower than that of caudal artery and central artery group, We could conclude xenogeneic antigenicity of endothelial membrane for caudal artery was higher than that for central artery, and we could use acellular small vessel scaffolds for xenogeneic vascular transplantation.
Study on slope stability of waste dump with a weak layer using finite element limit analysis method
Chong Chen,Huayong Lv,Jianjian Zhao,Zhanbo Cheng,Huaiyuan Wang,Gao Xu 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.3
Slope stability is generally paid more attention to in slope protection works, especially for slope containing weak layers. Two indexes of safety factor and failure model are selected to perform slope stability. Moreover, the finite element limit analysis method comprehensively combines the advantage of the limit analysis method and the finite element method obtaining the upper and lower bounds of the safety factor and the failure mode under the slope stability limit state. In this study, taking a waste dump containing a weak layer as an engineering background, the finite element limit analysis method is adopted to explore the potential failure mode. Meanwhile, the sensitivity analysis of slope stability is performed on geometrical and geotechnical parameters of the waste dump. The results show that the failure mode of the waste dump slope is two wedges if the weak layer is located on the ground surface (Model A), while the slope can be observed as three wedges failure if the weak layer is below the ground surface (Model B). In addition, both failure modes are highly sensitive to the friction angle of the weak layer and the shear strength of waste disposal, and moderately sensitive to the heap height, the dip angle and cohesion of the weak layer, while the toe cutting has limited effect on the slope stability. Moreover, the sensitivity to the excavation of the ground depends on the location of the weak layer and failure mode.