http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Du Hyeong Hwang ),( Yong Il Kim ),( Kwan Hyung Cho ),( Bijay Kumar Poudel ),( Ju Yeon Choi ),( Dong Wuk Kim ),( Young Jun Shin ),( Ok Nam Bae ),( Abid Mehmood Yousaf ),( Chul Soon Yong ),( Jong Oh K 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
A surface-attached silymarin-loaded solid dispersion with improved dissolution profile and enhanced oral bioavailability was formulated using silymarin, polyvinylpyrrolidone (PVP) and Tween 80 in water. In this solid dispersion, hydrophilic PVP was adhered onto the surface of crystalline drug rendering silymarin hydrophilic without changing its crystallinity. The drug solubility from the optimised solid dispersion prepared with silymarin/PVP/Tween 80 at the weight ratio of 5/2.5/2.5 increased by almost 650-fold compared to drug powder. The drug was physically and chemically stable in the solid dispersion for at least 6 months. Moreover, the solid dispersion enhanced the oral bioavailability of the drug in rats by almost 3-fold compared to the commercial product. The silymarin-loaded solid dispersion also exhibited advanced hepatoprotective bioactivity against CCl4-induced liver damage compared to silymarin or the commercial product. Thus, this silymarin-loaded solid dispersion would be useful for the enhancement of oral bioavailability and hepatoprotective activity of poorly water-soluble silymarin.
( Kwan Yeol Yang ),( Du Hyeong Hwang ),( Abid Mehmood Yousaf ),( Dong Wuk Kim ),( Young Jun Shin ),( Ok Nam Bae ),( Yong Ii Kim ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
BACKGROUND: The purpose of this study was to develop a novel silymarin-loaded solid nanoparticle system with enhanced oral bioavailability and an ability to provide excellent hepatic protection for poorly water-soluble drugs using Shirasu porous glass (SPG) membrane emulsification and a spray-drying technique. METHODS: A silymarin-loaded liquid nanoemulsion was formulated by applying the SPG membrane emulsification technique. This was further converted into solid state nanosized particles by the spray-drying technique. The physicochemicalcharacteristics of these nanoparticles were determined by scanning electron microscopy, differential scanning calorimetry, and powder X-ray diffraction. Their dissolution, bioavailability, and hepatoprotective activity in rats were assessed by comparison with a commercially available silymarin-loaded product. RESULTS: Formulation of a silymarin-loaded nanoemulsion, comprising silymarin, castor oil, polyvinylpyrrolidone, Transcutol HP, Tween 80, and water at a weight ratio of 5/3/3/1.25/1.25/100 was accomplished using an SPG membrane emulsification technique at an agitator speed of 700 rpm, a feed pressure of 15 kPa, and a continuous phase temperature of 25°C. This resulted in generation of comparatively uniform emulsion globules with a narrow size distribution. Moreover, the silymarin-loaded solid nanoparticles, containing silymarin/castor oil/polyvinylpyrrolidone/Transcutol HP/Tween 80 at a weight ratio of 5/3/3/1.25/1.25, improved about 1,300-fold drug solubility and retained a mean size of about 210 nm. Silymarin was located in unaltered crystalline form in the nanoparticles. The drug dissolved rapidly from the nanoparticles, reaching nearly 80% within 15 minutes, indicating three-fold better dissolution than that of the commercial product. Further, the nanoparticles showed a considerably shorter time to peak concentration, a greater area under the concentration-time curve, and a higher maximum concentration of silymarin compared with the commercial product (P < 0.05). In particular, the area under the concentration-time curve of the drug provided by the nanoparticles was approximately 1.3-fold greater than that of the commercial product. In addition, the silymarin-loaded nanoparticles significantly reduced carbon tetrachloride-induced hepatotoxicity, indicating improved bioactivity compared with silymarin powder and the commercial product. CONCLUSION: Silymarin-loaded nanoparticles developed using SPG membrane emulsification and spray-drying techniques could be a useful system for delivery of poorly water-soluble silymarin while affording excellent hepatic protection.
다중 주파수의 체적산란강도 차이를 이용한 에코그램 내에서의 종 분리와 잡음 제거
강돈혁 ( Kang Don Hyeog ),신형철 ( Sin Hyeong Cheol ),김수암 ( Kim Su Am ),이윤호 ( Lee Yun Ho ),황두진 ( Hwang Du Jin ) 한국수산과학회 2003 한국수산과학회지 Vol.36 No.5
N/A Species identification in hydroacoustic survey is one of the key requirements to estimate biomass of organism and to understand the structure of zooplankton community. Feasibility of species identification using two frequencies (38 and 120 kHz) was investigated on the basis of mean volume backscattering strength difference (MVBS). Virtual echogram technique was applied to two frequencies data sets that obtained from surveys in the Antarctic Ocean and Yellow Sea. Virtual echogram method using MVBS revealed the possibility of species identification, which species identification relying on visual scrutiny of single frequency acoustic data resulted in significant errors in biomass estimation. Through noise cancellation using MVBS, much of the acoustic noise caused by acoustic instruments could be removed in new virtual echogram, and the biomass estimation and data quality was improved.
동중국해에서 노무라입깃해파리의 in situ음향산란특성
윤은아 ( Eun A Yoon ),황두진 ( Doo Jin Hwang ),신형호 ( Hyeong Ho Shin ),곽두성 ( Du Seong Gwak ),차철표 ( Cheol Pyo Cha ) 한국어업기술학회 2012 수산해양기술연구 Vol.48 No.3
The Nemopilema nomurai is a large jellyfish attaining a weight of 200 kg and bell diameter of 2 m when fully grown. To prevent damage to this species, this study determined the acoustic characteristics of N. nomurai using frequencies 38 and 120 kHz. The CPUE of N. nomurai and the averaged SV of 38 and 120 kHz had a lower (+) correlation coefficient and relationship at 120 kHz (R〓0.51) than at 38 kHz (R〓 0.15) was significant. In addition, the averaged SV at 120 kHz was higher than at 38 kHz. The DMVBS120-38 in section catches≥97.8% wet mass of N. nomurai was -2.2 to 5.6 dB. The DTS120-38 in situ TS was extracted in sections catches of only N. nomurai by FMT. It was found that the averaged in situ DTS120-38 were at 0.6 and 0.1 dB. Furthermore, it results showed a close relationship between the bell diameter and TS of N. nomurai. The dominance of smaller N. nomurai (11.0~20.0 cm bell diameter in the air) corresponded to a similar proportion of low TS values (-69.0~-65.0 dB). A small number of larger N. nomurai (25.0~ 38.0 cm bell diameter in the air) were collected, in which TS values were the highest (-62.0~-58.0 dB).
Improving the Performance of Tin Oxide Thin-Film Transistors by Using Ultralow Pressure Sputtering
Huh, Myung Soo,Yang, Bong Seob,Oh, Seungha,Kim, Jeong-hwan,Du Ahn, Byung,Lee, Je-Hun,Kim, Joohan,Jeong, Jae Kyeong,Hwang, Cheol Seong,Kim, Hyeong Joon The Electrochemical Society 2010 Journal of the Electrochemical Society Vol.157 No.4