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Chronic Periodontitis and Risk of Lung Cancer: A Nationwide Longitudinal Cohort Study
( Bo-guen Kim ),( Dong Won Park ),( Hyun Lee ),( Sun-kyung Lee ),( Sun Young Paik ),( Seo-hyoung Yun ),( Chang-joo Park ),( Yoomi Yeo ),( Tai Sun Park ),( Ji-yong Moon ),( Tae-hyung Kim ),( Jang Won S 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
Kim Bo-Guen,Jeong Byeong-Ho,Kim Hojoong 대한의학회 2023 Journal of Korean medical science Vol.38 No.39
Background: After relieving stenosis with an airway silicone stent in post-tuberculosis bronchial stenosis (PTTS), stent removal is attempted if it is determined that airway patency can be maintained even after stent removal. However, the factors affecting airway stent removal are not well known. We investigate the factors that enable the successful removal of airway silicone stents in patients with PTTS. Methods: We retrospectively analyzed PTTS patients who underwent bronchoscopic intervention from January 2004 to December 2019. Successful stent removal is defined as airway patency maintained when the stent is removed, so that reinsertion of the stent is not required. A multivariate logistic regression analysis was used to identify independent factors associated with successful stent removal at the first attempt. Results: Total 344 patients were analyzed. Patients were followed up for a median of 47.9 (26.9–85.2) months after airway stent insertion. Approximately 69% of PTTS patients finally maintained airway patency after the stent was removed. Factors related to successful stent removal at the first attempt were older age and male sex. Absence of parenchymal calcification, segmental consolidation & bronchiolitis, and no trachea involved lesion were relevant to the successful stent removal. Stent dwelling for 12–24 months was associated with successful stent removal compared to a duration of less than 12 months. Conclusion: For patients whose airway patency is determined to be maintained even without a stent, it is necessary to attempt stent removal in consideration of factors related to successful stent removal.
Risk of Ischemic Heart Disease in Chronic Obstructive Pulmonary Disease: A Nationwide Cohort Study
Kim Bo-Guen,Lee Hyun,Kang Min Gu,Kim Jong Seung,Moon Ji-Yong 대한의학회 2023 Journal of Korean medical science Vol.38 No.42
Background: Subjects with chronic obstructive pulmonary disease (COPD) have a higher risk of ischemic heart disease (IHD) than individuals without COPD; however, longitudinal evidence is lacking. Therefore, we aimed to estimate the risk of IHD between COPD and control cohorts using a longitudinal nationwide database. Methods: We used 2009–2017 data from the Korean National Health Insurance Service National Sample Cohort (NHIS-NSC). Adult participants at least 20 years of age who underwent health examinations and without a history of COPD or IHD were included (n = 540,976). Participants were followed from January 1, 2009, until death, development of IHD, or December 31, 2019, whichever came first. Results: At baseline, there were 3,421 participants with incident COPD and 537,555 participants without COPD. During a median of 8.0 years (5.3–9.1 years) of follow-up, 2.51% of the participants with COPD (n = 86) and 0.77% of the participants without COPD (n = 4,128) developed IHD, with an incidence of 52.24 and 10.91 per 10,000 person-years, respectively. Participants with COPD had a higher risk of IHD (adjusted hazard ratio, 1.55; 95% confidence interval, 1.25–1.93) than subjects without COPD. Demographics such as age, sex, body mass index, and personal health behaviors including smoking status and physical activity did not show significant interaction with the relationship between COPD and IHD (P for interaction > 0.05 for all). Conclusion: The results indicate that COPD is associated with the development of IHD independent of demographic characteristics and health-related behaviors. Based on these results, clinicians should closely monitor the onset of IHD in subjects with COPD.
New-onset Asthma After COVID-19 Infection: A Nationwide Population-based Cohort Study
( Bo-guen Kim ),( Hyun Lee ),( Sang Woo Yeom ),( Cho Yun Jeong ),( Dong Won Park ),( Tai Sun Park ),( Ji-yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Jong Seung Kim ),( Sang-heon 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
( Bo-guen Kim ),( Byeong-ho Jeong ),( Sang-won Um ),( Hojoong Kim ),( Heejin Yoo ),( Seonwoo Kim ),( Kyungjong Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) helps facilitate the diagnosis of peripheral lung lesions. However, the prevention of infectious complications after EBUS-TBB has not been well established. Therefore, we analyzed short term oral antibiotics effects on the prevention of infectious complications. Methods We retrospectively analyzed 484 patients from the Radial EBUS Registry. Patients who underwent EBUS-TBB from March 2018 to March 2019 did not receive prophylactic antibiotics (“no prophylactic” group, n = 233), while patients who underwent EBUS-TBB from April 2019 to March 2020 did receive prophylactics (oral amoxicillin/clavulanate for 3 days; “prophylactic” group, n = 251). Multivariable logistic regression was used to identify independent factors for infectious complications. Results The median age of the study population was 66 years (IQR: 59-74 years), and 58.9% were male. Slightly over half of the patients (54.4%) were previous or current smokers. In 13% (n = 63) of patients, the procedure was performed using a guide sheath. Infectious complications occurred in 12 (5.2%) and 2 (0.8%) cases in the no prophylactic and prophylactic groups, respectively. In multivariable analysis, infectious complication was significantly related with cavitation (adjusted odds ratio [aOR], 9.065; 95% confidence interval [CI], 2.229-36.861; p = 0.002), low-density attenuation (LDA) of the lesion (aOR, 14.791; 95% CI, 3.969-55.114; p < 0.001), and combined obstructive pneumonic consolidation (aOR, 11.663; 95% CI, 1.259-108.030; p = 0.031), but prophylactic antibiotics was not a statistically significant factor (aOR, 0.251; 95% CI, 0.048-1.309; p = 0.101). In subgroup analysis, infectious complication occurred less when prophylactic antibiotics were used in patients with at least one risk factors (22.4% vs. 0%, p = 0.005). Conclusions Prophylactic antibiotics helped reduce the incidence of infectious complications after EBUS-TBB, especially patients with risk factors, such as cavitation, LDA in the lesion, and combined obstructive pneumonic consolidation.
( Bo-guen Kim ),( Hye Yun Park ),( Sun Hye Shin ),( Yong Suk Jo ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Fractional exhaled nitric oxide (FeNO) is a useful biomarker for detecting eosinophilic airway inflammation. However, in chronic obstructive pulmonary disease (COPD), the role of FeNO remains controversial. Therefore, we aimed to assess whether high FeNO itself and Resultant treatment change into ICS-containing regimen is associated with acute exacerbation (AE) of COPD patients. Methods We retrospectively analyzed 205 COPD patients from March 2016 to December 2019 in two referral hospitals. Patients who previously diagnosed with asthma were excluded. All patients were followed-up over six months after FeNO measurement. The patients whose FeNO value more than 50 parts per billion [ppb] were defined into high FeNO group. Multivariable analysis with logistic regression was used to identify factors associated with AE of COPD. Results The mean FeNO value for all patients was 30 (20-45) ppb. Of all patients, 39 (19.0%) patients were in high FeNO group with mean FeNO value of 73 (58-97) ppb. In the high FeNO group, 23 (23/39, 59%) patients changed treatment after the measurement of FeNO and all received ICS-containing treatment regimen. In multivariate analysis, high FeNO was not associated with AE while only history of exacerbation in the previous year was associated with AE (adjusted odds ratio [aOR], 2.250; 95% confidence interval [CI], 1.150-4.403; p = 0.018). A subgroup analysis was performed with a high FeNO group; the ICS use was not a significant factor related to AE. Conclusions In COPD patients, high FeNO did not affect the risk of AE, and changing into ICS-containing treatment in high FeNO did not prevent AE.