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성상세포교종에서의 BUdR, AgNOR's, PCNA에 대한 비교연구
이원창,신문수,정남,허승곤,이혜경 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.12
In 14 cases of astocytoma, we performed a comparative study of BUdR, AgNOR's, and PCNA with histopathology. Fourteen astrocytomas were classified histopathologically into low grade, anaplastic, and G.M.(glioblastoma multiforme) groups. These comprised 3 G.M., 5 anaplastic astrocytomas, and 6 low grade astrocytomas. The mean BUdR-LI(Labeling Index) was statistically different(P<0.005) between G.M.(10.4), anaplastic astrocytoma(3.6), and low grade astrocytoma(1.3). On the basis of correlation between BUdR-LI and histopathology which was reported in 1989 at PMC, we examined the relationship between BUdR-LI and AgNOR's count, and between BUdR-LI and PCNA-LI, Both AgNOR's count and PCNA-LI did not correlate with BUdR-LI, and also not with histopathology. This study indicates that, at present, for prognosis and differentiation between malignant and benign astrocytoma, histopathlogy and BUdR-LI are important.
뇌종양에서 에스트로겐 및 프로게스테론의 수용체와 종양세포의 증식도와의 상관관계
조경기,신성혜,정상섭 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.1
Steroid receptors have been sugessted to play an important role in the synthesis of DNA and the growth of cells. Authors have estimated the concentrations of estrogen and progesteron receptors using the ELISA method, and the proliferative potential using immunohistochemical stain with the monoclonal antibody to bromodeoxyuridine(BUdR) in 46 human brain tumors(21 meningiomas, 12 astrocytomas, 7 schwannoma. 4 medullobastomas, and 2 pituitary tumors). In our studies, the concentration of receptors had no relationship with age and sex of patients, and tumor type, and the proliferative potential of the individual tumors.